| MeSH term | MeSH ID | Detail |
|---|---|---|
| Anisakiasis | D017129 | 2 associated lipids |
| Candidiasis, Invasive | D058365 | 2 associated lipids |
| Nerve Sheath Neoplasms | D018317 | 4 associated lipids |
| Neuritis, Autoimmune, Experimental | D009444 | 4 associated lipids |
| Head Injuries, Closed | D016489 | 5 associated lipids |
| Hypergammaglobulinemia | D006942 | 9 associated lipids |
| Neurilemmoma | D009442 | 10 associated lipids |
| Meningioma | D008579 | 11 associated lipids |
| Candidiasis, Oral | D002180 | 11 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Krishnakumaran A and Schneiderman HA | Prothoracotrophic activity of compounds that mimic juvenile hormone. | 1965 | J. Insect Physiol. | pmid:5848789 |
| Schneiderman HA et al. | Juvenile hormone activity of structurally unrelated compounds. | 1965 | J. Insect Physiol. | pmid:5848792 |
| Azerad R and Cyrot MO | [Synthesis of 2 dihydrofarnesyl-naphthoquinones related to the vitamin K2(45)H of Mycobacterium phlei]. | 1965 | Bull Soc Chim Fr | pmid:5858127 |
| Buffatti G | [Geranyl farnesyl acetate in the treatment of gastroenteritis in the infant]. | 1965 | Clin Pediatr (Bologna) | pmid:5882341 |
| Monro J and Bailey PT | Influence of radiation on ovarian maturation and histolysis of pupal fat body in Diptera. | 1965 | Nature | pmid:5885870 |
| Patrassi G | [The relationship between collagenosis and rheumatic disease]. | 1966 | Concours Med | pmid:5904237 |
| Smejkal V et al. | [Antiulcerous effect of various esters of farnesylacetic acid on the gastric mucosa in guinea pigs and rats]. | 1966 | Cesk Gastroenterol Vyz | pmid:5934910 |
| Lima JP et al. | [Gefarnate (DA-688) in the treatment of peptic ulcer; immediate results]. | 1966 | Rev Bras Med | pmid:5940586 |
| Huelin FE and Murray KE | Alpha-farnesene in the natural coating of apples. | 1966 | Nature | pmid:5967802 |
| Peter MG et al. | [Identification of farnesol as an intermediate in the biosynthesis of cantharidin from mevalonolactone]. | 1977 | Helv. Chim. Acta | pmid:599044 |
| Van der Kloot WG | Goals and strategy of comparative pharmacology. | 1967 Jul-Aug | Fed. Proc. | pmid:6028781 |
| Spielman A and Skaff V | Inhibition of metamorphosis and of ecdysis in mosquitoes. | 1967 | J. Insect Physiol. | pmid:6043875 |
| Micciarelli AS | Effects of farnesyl methyl ether on embryos of Schistocerca Gregaria (Orthoptera). | 1977 | Acta Embryol Exp (Palermo) | pmid:605750 |
| Richards WR and Rapoport H | The biosynthesis of chlorobium chlorophylls-660. The production of magnesium protoporphyrin monomethyl ester, bacteriochlorophyll, and chlorobium pheoporphyrins by Chlorobium thiosulfatophilum-660. | 1967 | Biochemistry | pmid:6076631 |
| L'Hélias C | [Study on deshydrogenases implicated in control of farnesol and juvenile hormone metabolisms in Pieris brassicae (author's transl)]. | 1977 | Ann. Endocrinol. (Paris) | pmid:612274 |
| Baker FC et al. | Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta. | 1983 | J. Lipid Res. | pmid:6366103 |
| Wegner Z | Insecticidal action of "Cyklopren" against mosquitoes in minute artificial water containers. | 1984 | Bull Inst Marit Trop Med Gdynia | pmid:6545940 |
| Krzemińska A et al. | [Field studies on the effectiveness of insecticides containing juvenile hormones against the ant Monomorium pharaonis L]. | 1983 | Rocz Panstw Zakl Hig | pmid:6612185 |
| Koeppe JK et al. | A specific photoaffinity label for hemolymph and ovarian juvenile hormone-binding proteins in Leucophaea maderae. | 1984 | J. Biol. Chem. | pmid:6699014 |
| Takahashi I and Ogura K | Farnesyl pyrophosphate synthetase from Bacillus subtilis. | 1981 | J. Biochem. | pmid:6792191 |
| Cantwell SG et al. | Biodegradation of acyclic isoprenoids by Pseudomonas species. | 1978 | J. Bacteriol. | pmid:681275 |
| Parker TS et al. | Inhibition of liver prenyltransferase by alkyl phosphonates and phosphonophosphates. | 1978 | Biochim. Biophys. Acta | pmid:687653 |
| Nishino T et al. | Enzymatic formation of nerolidol in cell-free extract of Rhodotorula glutinis. | 1982 | J. Biochem. | pmid:6891702 |
| Fukui S | [Sexual differentiation in heterobasidiomycetous yeasts (author's transl)]. | 1980 | Seikagaku | pmid:7019358 |
| Miyakawa T et al. | Role of metabolism of the mating pheromone in sexual differentiation of the heterobasidiomycete Rhodosporidium toruloides. | 1982 | J. Bacteriol. | pmid:7050081 |
| Kamiya Y et al. | Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides. | 1978 | Biochem. Biophys. Res. Commun. | pmid:708426 |
| Saito A and Rilling HC | The formation of cyclic sesquiterpenes from farnesyl pyrophosphate by prenyltransferase. | 1981 | Arch. Biochem. Biophys. | pmid:7259201 |
| Saito Y and Ogura K | Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions. | 1981 | J. Biochem. | pmid:7275947 |
| Baba T and Allen CM | Substrate specificity of undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum. | 1978 | Biochemistry | pmid:728420 |
| Styczyńska B and Krzemińska A | [Laboratory testing of control of the Monomorium pharaonis L. ants with the use of juvenile hormones]. | 1981 | Rocz Panstw Zakl Hig | pmid:7313455 |
| Koyama T et al. | Substrate specificity of squalene synthetase. | 1980 | Biochim. Biophys. Acta | pmid:7357018 |
| Kamiya Y et al. | Metabolites of mating pheromone, rhodotorucine A, by a cells of Rhodosporidium toruloides. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7396935 |
| Tsuchiya E and Fukui S | Binding of rhodotorucine A, a lipopeptidyl mating hormone, to a cells of Rhodosporidium toruloides for induction of sexual differentiation. | 1978 | Biochem. Biophys. Res. Commun. | pmid:743290 |
| Styczyńska B et al. | [Biological activity of the Polish juvenile hormone cyclopren tested on various Diptera species]. | 1980 | Rocz Panstw Zakl Hig | pmid:7466235 |
| Kisselev O et al. | Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. | 1995 | J. Biol. Chem. | pmid:7592699 |
| Corsini A et al. | Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. | 1995 | Am. J. Cardiol. | pmid:7604791 |
| Voziyan PA et al. | Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626062 |
| Meigs TE et al. | Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. | 1995 | Exp. Cell Res. | pmid:7641798 |
| Epand RM et al. | Lipid-mediated a-factor interactions with artificial membranes. | 1995 | Meth. Enzymol. | pmid:7651149 |
| Marom M et al. | Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. | 1995 | J. Biol. Chem. | pmid:7673206 |
| Gilbert BA et al. | Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. | 1995 | Biochemistry | pmid:7696255 |
| Marciano D et al. | Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. | 1995 | J. Med. Chem. | pmid:7731012 |
| Fliesler SJ and Keller RK | Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7763243 |
| Forman BM et al. | Identification of a nuclear receptor that is activated by farnesol metabolites. | 1995 | Cell | pmid:7774010 |
| Crick DC et al. | Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7794274 |
| Bondar OP et al. | Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. | 1994 | Chem. Phys. Lipids | pmid:7820904 |
| Yazlovitskaya EM and Melnykovych G | Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. | 1995 | Cancer Lett. | pmid:7874691 |
| Munro E et al. | Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. | 1994 | Eur. J. Clin. Invest. | pmid:7890015 |
| Søgaard M et al. | A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. | 1994 | Cell | pmid:7923363 |
| Aronheim A et al. | Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | 1994 | Cell | pmid:7923364 |
| Biermann BJ et al. | Novel isoprenylated proteins identified by an expression library screen. | 1994 | J. Biol. Chem. | pmid:7929216 |
| Mallat A et al. | Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. | 1994 | Hepatology | pmid:7982659 |
| Tojo K et al. | Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. | 1994 | Pharm. Res. | pmid:8008705 |
| Neuhüser T et al. | Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. | 1994 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8014257 |
| Adany I et al. | Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. | 1994 | Cancer Lett. | pmid:8019976 |
| Correll CC et al. | Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1994 | J. Biol. Chem. | pmid:8021239 |
| Cox AD et al. | The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. | 1994 | J. Biol. Chem. | pmid:8034681 |
| Haug JS et al. | Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. | 1994 | Biochim. Biophys. Acta | pmid:8061045 |
| Kisselev OG et al. | A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. | 1994 | J. Biol. Chem. | pmid:8063769 |
| Lübben M and Morand K | Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. | 1994 | J. Biol. Chem. | pmid:8063781 |
| Fukada Y et al. | Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. | 1994 | J. Biol. Chem. | pmid:8106497 |
| Caldwell GA et al. | Consequences of altered isoprenylation targets on a-factor export and bioactivity. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8108401 |
| Ledoux A | [Effect of a farnesol derivative on the appearance of winged females in aphaenogaster senilis (Hymenoptera, Formicoidea)]. | 1976 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:817818 |
| Inoue H et al. | Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8179579 |
| Kothapalli R et al. | Effects of long-chain fatty amines on the growth of ras-transformed NIH 3T3 cells. | 1994 | Biochem. Pharmacol. | pmid:8204109 |
| Corsini A et al. | Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. | 1993 | Atherosclerosis | pmid:8216498 |
| Voziyan PA et al. | Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. | 1993 | Biochem. J. | pmid:8240288 |
| Inoue H et al. | Formation of farnesal and 3-hydroxy-2,3-dihydrofarnesal from farnesol by protoplasts of Botryococcus braunii. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8250896 |
| Foster JM et al. | Biosynthesis of isoprenoid compounds in Schistosoma mansoni. | 1993 | Mol. Biochem. Parasitol. | pmid:8264731 |
| Kothapalli R et al. | Farnesylamine: an inhibitor of farnesylation and growth of ras-transformed cells. | 1993 | Lipids | pmid:8277827 |
| Akopyan TN et al. | Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8297391 |
| Touhara K and Prestwich GD | Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs. | 1993 | J. Biol. Chem. | pmid:8396141 |
| O'Donnell MP et al. | Lovastatin inhibits proliferation of rat mesangial cells. | 1993 | J. Clin. Invest. | pmid:8423236 |
| Gibbs JB et al. | Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. | 1993 | J. Biol. Chem. | pmid:8463291 |
| Prashad M et al. | N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors. | 1993 | J. Med. Chem. | pmid:8496919 |
| Tachibana A et al. | Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. | 1996 | FEBS Lett. | pmid:8566226 |
| Parmryd I et al. | Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. | 1995 | Eur. J. Biochem. | pmid:8575428 |
| O'Brien ML et al. | Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. | 1996 | Carcinogenesis | pmid:8625436 |
| Meigs TE et al. | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. | 1996 | J. Biol. Chem. | pmid:8626470 |
| Boisvenue RJ et al. | Haemonchus contortus: effects of compounds with juvenile hormone activity on the in vitro development of infective larvae. | 1977 | Exp. Parasitol. | pmid:862711 |
| Roullet JB et al. | Farnesyl analogues inhibit vasoconstriction in animal and human arteries. | 1996 | J. Clin. Invest. | pmid:8636420 |
| Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
| Crick DC et al. | Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells. | 1996 | SAAS Bull. Biochem. Biotechnol. | pmid:8652130 |
| Tanaka H et al. | MEKA/phosducin attenuates hydrophobicity of transducin beta gamma subunits without binding to farnesyl moiety. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687440 |
| Koyama T et al. | Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. | 1996 | Biochemistry | pmid:8755734 |
| Nishio E et al. | 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). | 1996 | Eur. J. Pharmacol. | pmid:8773465 |
| Miquel K et al. | Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780704 |
| Satoh T et al. | The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. | 1996 | Life Sci. | pmid:8831797 |
| Umetani N et al. | Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. | 1996 | Biochim. Biophys. Acta | pmid:8908154 |
| McGuire TF et al. | Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. | 1996 | J. Biol. Chem. | pmid:8910319 |
| Peter MG et al. | [Incorporation experiments with (3H and 14C) doubly labelled farnesols into cantharidin (author's transl)]. | 1977 | Helv. Chim. Acta | pmid:893117 |
| Willumsen BM et al. | Novel determinants of H-Ras plasma membrane localization and transformation. | 1996 | Oncogene | pmid:8934536 |
| Vogt A et al. | Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. | 1996 | Oncogene | pmid:8934546 |
| Carel K et al. | Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. | 1996 | J. Biol. Chem. | pmid:8940037 |
| Styczyńska B et al. | [2,3-methylenefarnesenic acid derivatives as juvenile hormone analogs against housefly (Musca domestica L.)]. | 1977 | Wiad Parazytol | pmid:899003 |
| Westfall D et al. | Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9015362 |
| King HL and Rilling HC | Avian liver prenyltransferase. The role of metal in substrate binding and the orientation of substrates during catalysis. | 1977 | Biochemistry | pmid:901755 |
| Tisch D et al. | Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. | 1996 | Eur. J. Biochem. | pmid:9022678 |
| Tamone SL et al. | Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. | 1997 | Gen. Comp. Endocrinol. | pmid:9038249 |
| Denda M et al. | Epidermal injury stimulates prenylation in the epidermis of hairless mice. | 1997 | Arch. Dermatol. Res. | pmid:9049045 |