2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Candidiasis, Invasive D058365 2 associated lipids
Anisakiasis D017129 2 associated lipids
Nerve Sheath Neoplasms D018317 4 associated lipids
Neuritis, Autoimmune, Experimental D009444 4 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Neurilemmoma D009442 10 associated lipids
Meningioma D008579 11 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Neoplasms, Glandular and Epithelial D009375 12 associated lipids
Lung Injury D055370 14 associated lipids
Dermatomycoses D003881 17 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Nephritis D009393 19 associated lipids
HIV Infections D015658 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Fibrosis D005355 23 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Glioblastoma D005909 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

Download all related citations
Per page 10 20 50 100 | Total 950
Authors Title Published Journal PubMed Link
Bhandari J et al. Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. 2010 Plant Physiol. pmid:20807998
Schnee C et al. The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. 2002 Plant Physiol. pmid:12481088
Hemmerlin A and Bach TJ Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in tobacco cv bright yellow-2 cells. 2000 Plant Physiol. pmid:10938345
Fitzpatrick AH et al. Roles for farnesol and ABA in Arabidopsis flower development. 2011 Plant Signal Behav pmid:21758018
Cantrell CL et al. Antimycobacterial plant terpenoids. 2001 Planta Med. pmid:11731906
Shin KO et al. Terpene alcohols inhibit de novo sphingolipid biosynthesis. 2012 Planta Med. pmid:22274813
Rajab MS et al. Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study. 1998 Planta Med. pmid:9491760
Vik A et al. Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro. 2007 Planta Med. pmid:17924309
Nevo Y et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. 2011 PLoS ONE pmid:21445359
Zhang L et al. Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. 2011 PLoS ONE pmid:22174935
Chang W et al. Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. 2012 PLoS ONE pmid:22848547
Fu MS et al. Functional characterization of the small heat shock protein Hsp12p from Candida albicans. 2012 PLoS ONE pmid:22880130
Zhu J et al. Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. 2016 PLoS ONE pmid:26959814
Nyati P et al. Farnesyl phosphatase, a Corpora allata enzyme involved in juvenile hormone biosynthesis in Aedes aegypti. 2013 PLoS ONE pmid:23940797
Schokoroy S et al. Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death. 2013 PLoS ONE pmid:24086490
Mologni L et al. Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. 2012 PLoS ONE pmid:23227266
Mor A et al. Ras inhibition induces insulin sensitivity and glucose uptake. 2011 PLoS ONE pmid:21738773
Jung SI et al. Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades. 2016 PLoS ONE pmid:26848577
Krause J et al. Prostaglandin E2 from Candida albicans Stimulates the Growth of Staphylococcus aureus in Mixed Biofilms. 2015 PLoS ONE pmid:26262843
Strube-Bloss MF et al. Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris. 2015 PLoS ONE pmid:26340263