2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |
Roullet JB et al. | Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. | 1997 | J. Hypertens. | pmid:9488229 |
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Saisho Y et al. | Determination of farnesyl pyrophosphate in dog and human plasma by high-performance liquid chromatography with fluorescence detection. | 1997 | Anal. Biochem. | pmid:9324945 |
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Gana-Weisz M et al. | The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9367867 |
Goossens A and Merckx L | Allergic contact dermatitis from farnesol in a deodorant. | 1997 | Contact Derm. | pmid:9385513 |
Meigs TE and Simoni RD | Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. | 1997 | Arch. Biochem. Biophys. | pmid:9281305 |
Takaichi S et al. | The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene. | 1997 | Arch. Microbiol. | pmid:9297464 |
Crick DC et al. | Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299388 |
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Denda M et al. | Epidermal injury stimulates prenylation in the epidermis of hairless mice. | 1997 | Arch. Dermatol. Res. | pmid:9049045 |
Tamone SL et al. | Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. | 1997 | Gen. Comp. Endocrinol. | pmid:9038249 |
Westfall D et al. | Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9015362 |
Ghosh PM et al. | Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. | 1997 | Biochim. Biophys. Acta | pmid:9398081 |
Zhang L et al. | Isolation and characterization of a prenylcysteine lyase from bovine brain. | 1997 | J. Biol. Chem. | pmid:9287348 |
Andres DA et al. | Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. | 1997 | Arch. Biochem. Biophys. | pmid:9328291 |
Iazlovitskaia EM et al. | Human leukemia CEM C-1 cells possess a high affinity binding site for farnesol. | 1997 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9463231 |
Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
Hohl RJ et al. | Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids. | 1998 | Lipids | pmid:9470172 |
Aharonson Z et al. | Stringent structural requirements for anti-Ras activity of S-prenyl analogues. | 1998 | Biochim. Biophys. Acta | pmid:9545527 |
Ura H et al. | Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts. | 1998 | Mol. Carcinog. | pmid:9496909 |
Haklai R et al. | Dislodgment and accelerated degradation of Ras. | 1998 | Biochemistry | pmid:9477957 |
Hampton RY | Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation. | 1998 | Curr. Opin. Lipidol. | pmid:9559264 |
Desrosiers RR and Béliveau R | Regulation by GTPgammaS of protein carboxylmethyltransferase activity in kidney brush border membranes. | 1998 | Arch. Biochem. Biophys. | pmid:9514644 |
Miquel K et al. | Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. | 1998 | J. Biol. Chem. | pmid:9748300 |
Laezza C et al. | v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9811854 |
Ferdinandy P et al. | Rapid pacing-induced preconditioning is recaptured by farnesol treatment in hearts of cholesterol-fed rats: role of polyprenyl derivatives and nitric oxide. | 1998 | Mol. Cell. Biochem. | pmid:9774182 |
Shipman CM et al. | The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | 1998 | Cancer Res. | pmid:9850051 |
Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
Bentinger M et al. | Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase. | 1998 | Arch. Biochem. Biophys. | pmid:9606952 |
Nishio E et al. | Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. | 1998 | Eur. J. Pharmacol. | pmid:9650858 |
Szilvassy Z et al. | Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits. | 1998 | Eur. J. Pharmacol. | pmid:9721042 |
Machida K et al. | Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae. | 1998 | J. Bacteriol. | pmid:9721283 |
Strickland CL et al. | Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. | 1998 | Biochemistry | pmid:9843427 |
Rajab MS et al. | Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study. | 1998 | Planta Med. | pmid:9491760 |
Llorente-Cortés V et al. | Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9598832 |
Pérez-Sala D et al. | Analogs of farnesylcysteine induce apoptosis in HL-60 cells. | 1998 | FEBS Lett. | pmid:9600259 |
Rubins JB et al. | Lovastatin induces apoptosis in malignant mesothelioma cells. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603146 |
Crick DC et al. | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. | 1998 | J. Neurochem. | pmid:9603204 |
Pei ZM et al. | Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. | 1998 | Science | pmid:9765153 |
Machida K and Tanaka T | Farnesol-induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F(0)F(1)-ATPase in yeast. | 1999 | FEBS Lett. | pmid:10580101 |