2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

Cross Reference

Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Dermatomycoses D003881 17 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Insulin Resistance D007333 99 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

Download all related citations
Per page 10 20 50 100 | Total 950
Authors Title Published Journal PubMed Link
Krishnakumaran A and Schneiderman HA Prothoracotrophic activity of compounds that mimic juvenile hormone. 1965 J. Insect Physiol. pmid:5848789
Schneiderman HA et al. Juvenile hormone activity of structurally unrelated compounds. 1965 J. Insect Physiol. pmid:5848792
Azerad R and Cyrot MO [Synthesis of 2 dihydrofarnesyl-naphthoquinones related to the vitamin K2(45)H of Mycobacterium phlei]. 1965 Bull Soc Chim Fr pmid:5858127
Buffatti G [Geranyl farnesyl acetate in the treatment of gastroenteritis in the infant]. 1965 Clin Pediatr (Bologna) pmid:5882341
Monro J and Bailey PT Influence of radiation on ovarian maturation and histolysis of pupal fat body in Diptera. 1965 Nature pmid:5885870
Patrassi G [The relationship between collagenosis and rheumatic disease]. 1966 Concours Med pmid:5904237
Smejkal V et al. [Antiulcerous effect of various esters of farnesylacetic acid on the gastric mucosa in guinea pigs and rats]. 1966 Cesk Gastroenterol Vyz pmid:5934910
Lima JP et al. [Gefarnate (DA-688) in the treatment of peptic ulcer; immediate results]. 1966 Rev Bras Med pmid:5940586
Huelin FE and Murray KE Alpha-farnesene in the natural coating of apples. 1966 Nature pmid:5967802
Peter MG et al. [Identification of farnesol as an intermediate in the biosynthesis of cantharidin from mevalonolactone]. 1977 Helv. Chim. Acta pmid:599044
Van der Kloot WG Goals and strategy of comparative pharmacology. 1967 Jul-Aug Fed. Proc. pmid:6028781
Spielman A and Skaff V Inhibition of metamorphosis and of ecdysis in mosquitoes. 1967 J. Insect Physiol. pmid:6043875
Micciarelli AS Effects of farnesyl methyl ether on embryos of Schistocerca Gregaria (Orthoptera). 1977 Acta Embryol Exp (Palermo) pmid:605750
Richards WR and Rapoport H The biosynthesis of chlorobium chlorophylls-660. The production of magnesium protoporphyrin monomethyl ester, bacteriochlorophyll, and chlorobium pheoporphyrins by Chlorobium thiosulfatophilum-660. 1967 Biochemistry pmid:6076631
L'Hélias C [Study on deshydrogenases implicated in control of farnesol and juvenile hormone metabolisms in Pieris brassicae (author's transl)]. 1977 Ann. Endocrinol. (Paris) pmid:612274
Baker FC et al. Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta. 1983 J. Lipid Res. pmid:6366103
Wegner Z Insecticidal action of "Cyklopren" against mosquitoes in minute artificial water containers. 1984 Bull Inst Marit Trop Med Gdynia pmid:6545940
Krzemińska A et al. [Field studies on the effectiveness of insecticides containing juvenile hormones against the ant Monomorium pharaonis L]. 1983 Rocz Panstw Zakl Hig pmid:6612185
Koeppe JK et al. A specific photoaffinity label for hemolymph and ovarian juvenile hormone-binding proteins in Leucophaea maderae. 1984 J. Biol. Chem. pmid:6699014
Takahashi I and Ogura K Farnesyl pyrophosphate synthetase from Bacillus subtilis. 1981 J. Biochem. pmid:6792191
Cantwell SG et al. Biodegradation of acyclic isoprenoids by Pseudomonas species. 1978 J. Bacteriol. pmid:681275
Parker TS et al. Inhibition of liver prenyltransferase by alkyl phosphonates and phosphonophosphates. 1978 Biochim. Biophys. Acta pmid:687653
Nishino T et al. Enzymatic formation of nerolidol in cell-free extract of Rhodotorula glutinis. 1982 J. Biochem. pmid:6891702
Fukui S [Sexual differentiation in heterobasidiomycetous yeasts (author's transl)]. 1980 Seikagaku pmid:7019358
Miyakawa T et al. Role of metabolism of the mating pheromone in sexual differentiation of the heterobasidiomycete Rhodosporidium toruloides. 1982 J. Bacteriol. pmid:7050081
Kamiya Y et al. Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides. 1978 Biochem. Biophys. Res. Commun. pmid:708426
Saito A and Rilling HC The formation of cyclic sesquiterpenes from farnesyl pyrophosphate by prenyltransferase. 1981 Arch. Biochem. Biophys. pmid:7259201
Saito Y and Ogura K Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions. 1981 J. Biochem. pmid:7275947
Baba T and Allen CM Substrate specificity of undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum. 1978 Biochemistry pmid:728420
Styczyńska B and Krzemińska A [Laboratory testing of control of the Monomorium pharaonis L. ants with the use of juvenile hormones]. 1981 Rocz Panstw Zakl Hig pmid:7313455
Koyama T et al. Substrate specificity of squalene synthetase. 1980 Biochim. Biophys. Acta pmid:7357018
Kamiya Y et al. Metabolites of mating pheromone, rhodotorucine A, by a cells of Rhodosporidium toruloides. 1980 Biochem. Biophys. Res. Commun. pmid:7396935
Tsuchiya E and Fukui S Binding of rhodotorucine A, a lipopeptidyl mating hormone, to a cells of Rhodosporidium toruloides for induction of sexual differentiation. 1978 Biochem. Biophys. Res. Commun. pmid:743290
Styczyńska B et al. [Biological activity of the Polish juvenile hormone cyclopren tested on various Diptera species]. 1980 Rocz Panstw Zakl Hig pmid:7466235
Kisselev O et al. Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. 1995 J. Biol. Chem. pmid:7592699
Corsini A et al. Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. 1995 Am. J. Cardiol. pmid:7604791
Voziyan PA et al. Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. 1995 Biochem. Biophys. Res. Commun. pmid:7626062
Meigs TE et al. Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. 1995 Exp. Cell Res. pmid:7641798
Epand RM et al. Lipid-mediated a-factor interactions with artificial membranes. 1995 Meth. Enzymol. pmid:7651149
Marom M et al. Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. 1995 J. Biol. Chem. pmid:7673206
Gilbert BA et al. Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. 1995 Biochemistry pmid:7696255
Marciano D et al. Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. 1995 J. Med. Chem. pmid:7731012
Fliesler SJ and Keller RK Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. 1995 Biochem. Biophys. Res. Commun. pmid:7763243
Forman BM et al. Identification of a nuclear receptor that is activated by farnesol metabolites. 1995 Cell pmid:7774010
Crick DC et al. Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. 1995 Biochem. Biophys. Res. Commun. pmid:7794274
Bondar OP et al. Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. 1994 Chem. Phys. Lipids pmid:7820904
Yazlovitskaya EM and Melnykovych G Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. 1995 Cancer Lett. pmid:7874691
Munro E et al. Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. 1994 Eur. J. Clin. Invest. pmid:7890015
Søgaard M et al. A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. 1994 Cell pmid:7923363
Aronheim A et al. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. 1994 Cell pmid:7923364