2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Arteriosclerosis D001161 86 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Dermatomycoses D003881 17 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Insulin Resistance D007333 99 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

Download all related citations
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Authors Title Published Journal PubMed Link
Biermann BJ et al. Novel isoprenylated proteins identified by an expression library screen. 1994 J. Biol. Chem. pmid:7929216
Mallat A et al. Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. 1994 Hepatology pmid:7982659
Tojo K et al. Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. 1994 Pharm. Res. pmid:8008705
Neuhüser T et al. Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. 1994 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:8014257
Adany I et al. Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. 1994 Cancer Lett. pmid:8019976
Correll CC et al. Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1994 J. Biol. Chem. pmid:8021239
Cox AD et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 1994 J. Biol. Chem. pmid:8034681
Haug JS et al. Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. 1994 Biochim. Biophys. Acta pmid:8061045
Kisselev OG et al. A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. 1994 J. Biol. Chem. pmid:8063769
Lübben M and Morand K Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. 1994 J. Biol. Chem. pmid:8063781
Fukada Y et al. Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. 1994 J. Biol. Chem. pmid:8106497
Caldwell GA et al. Consequences of altered isoprenylation targets on a-factor export and bioactivity. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8108401
Ledoux A [Effect of a farnesol derivative on the appearance of winged females in aphaenogaster senilis (Hymenoptera, Formicoidea)]. 1976 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:817818
Inoue H et al. Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. 1994 Biochem. Biophys. Res. Commun. pmid:8179579
Kothapalli R et al. Effects of long-chain fatty amines on the growth of ras-transformed NIH 3T3 cells. 1994 Biochem. Pharmacol. pmid:8204109
Corsini A et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. 1993 Atherosclerosis pmid:8216498
Voziyan PA et al. Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. 1993 Biochem. J. pmid:8240288
Inoue H et al. Formation of farnesal and 3-hydroxy-2,3-dihydrofarnesal from farnesol by protoplasts of Botryococcus braunii. 1993 Biochem. Biophys. Res. Commun. pmid:8250896
Foster JM et al. Biosynthesis of isoprenoid compounds in Schistosoma mansoni. 1993 Mol. Biochem. Parasitol. pmid:8264731
Kothapalli R et al. Farnesylamine: an inhibitor of farnesylation and growth of ras-transformed cells. 1993 Lipids pmid:8277827
Akopyan TN et al. Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15. 1994 Biochem. Biophys. Res. Commun. pmid:8297391
Touhara K and Prestwich GD Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs. 1993 J. Biol. Chem. pmid:8396141
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
Gibbs JB et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. 1993 J. Biol. Chem. pmid:8463291
Prashad M et al. N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors. 1993 J. Med. Chem. pmid:8496919
Tachibana A et al. Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. 1996 FEBS Lett. pmid:8566226
Parmryd I et al. Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. 1995 Eur. J. Biochem. pmid:8575428
O'Brien ML et al. Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. 1996 Carcinogenesis pmid:8625436
Meigs TE et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. 1996 J. Biol. Chem. pmid:8626470
Boisvenue RJ et al. Haemonchus contortus: effects of compounds with juvenile hormone activity on the in vitro development of infective larvae. 1977 Exp. Parasitol. pmid:862711
Roullet JB et al. Farnesyl analogues inhibit vasoconstriction in animal and human arteries. 1996 J. Clin. Invest. pmid:8636420
Keller RK et al. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Arch. Biochem. Biophys. pmid:8645011
Crick DC et al. Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells. 1996 SAAS Bull. Biochem. Biotechnol. pmid:8652130
Tanaka H et al. MEKA/phosducin attenuates hydrophobicity of transducin beta gamma subunits without binding to farnesyl moiety. 1996 Biochem. Biophys. Res. Commun. pmid:8687440
Koyama T et al. Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. 1996 Biochemistry pmid:8755734
Nishio E et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). 1996 Eur. J. Pharmacol. pmid:8773465
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Satoh T et al. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. 1996 Life Sci. pmid:8831797
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154
McGuire TF et al. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. 1996 J. Biol. Chem. pmid:8910319
Peter MG et al. [Incorporation experiments with (3H and 14C) doubly labelled farnesols into cantharidin (author's transl)]. 1977 Helv. Chim. Acta pmid:893117
Willumsen BM et al. Novel determinants of H-Ras plasma membrane localization and transformation. 1996 Oncogene pmid:8934536
Vogt A et al. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. 1996 Oncogene pmid:8934546
Carel K et al. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. 1996 J. Biol. Chem. pmid:8940037
Styczyńska B et al. [2,3-methylenefarnesenic acid derivatives as juvenile hormone analogs against housefly (Musca domestica L.)]. 1977 Wiad Parazytol pmid:899003
Westfall D et al. Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. 1997 Biochem. Biophys. Res. Commun. pmid:9015362
King HL and Rilling HC Avian liver prenyltransferase. The role of metal in substrate binding and the orientation of substrates during catalysis. 1977 Biochemistry pmid:901755
Tisch D et al. Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. 1996 Eur. J. Biochem. pmid:9022678
Tamone SL et al. Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. 1997 Gen. Comp. Endocrinol. pmid:9038249
Denda M et al. Epidermal injury stimulates prenylation in the epidermis of hairless mice. 1997 Arch. Dermatol. Res. pmid:9049045