2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zhang X et al. | PEG-farnesylthiosalicylate conjugate as a nanomicellar carrier for delivery of paclitaxel. | 2013 | Bioconjug. Chem. | pmid:23425093 |
Brilhante RS et al. | Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii. | 2013 | Antimicrob. Agents Chemother. | pmid:23459491 |
Mor A et al. | Immunomodulatory properties of farnesoids: the new steroids? | 2013 | Curr. Med. Chem. | pmid:23432580 |
Langford ML et al. | Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death. | 2013 | Eukaryotic Cell | pmid:23873867 |
Schmukler E et al. | Ras inhibition enhances autophagy, which partially protects cells from death. | 2013 | Oncotarget | pmid:23847721 |
Nyati P et al. | Farnesyl phosphatase, a Corpora allata enzyme involved in juvenile hormone biosynthesis in Aedes aegypti. | 2013 | PLoS ONE | pmid:23940797 |
Onono F et al. | Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. | 2013 | J. Biol. Chem. | pmid:23908355 |
Schokoroy S et al. | Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death. | 2013 | PLoS ONE | pmid:24086490 |
Kloog Y et al. | Ras chaperones: new targets for cancer and immunotherapy. | 2013 | Enzymes | pmid:25033809 |
Pfister C et al. | Detection and quantification of farnesol-induced apoptosis in difficult primary cell cultures by TaqMan protein assay. | 2013 | Apoptosis | pmid:23315006 |
Cerca N et al. | Farnesol induces cell detachment from established S. epidermidis biofilms. | 2013 | J. Antibiot. | pmid:23549353 |
Alves FR et al. | Antibiofilm and antibacterial activities of farnesol and xylitol as potential endodontic irrigants. | 2013 | Braz Dent J | pmid:23969910 |
Tashiro M et al. | Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis. | 2012 | Med. Mycol. | pmid:21954955 |
Jaggi AS and Singh N | Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. | 2012 | Food Chem. Toxicol. | pmid:22326968 |
Aizman E et al. | Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes. | 2012 | Oncotarget | pmid:22323550 |
Qamar W et al. | Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. | 2012 | Exp. Lung Res. | pmid:22168545 |
Mans RA et al. | Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. | 2012 | Neuroscience | pmid:22192838 |
Mashiach-Farkash E et al. | Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. | 2012 | Oncotarget | pmid:22776759 |
András IE et al. | Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22490665 |
Lichtor PA and Miller SJ | Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation. | 2012 | Nat Chem | pmid:23174978 |