2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Authors Title Published Journal PubMed Link
Lin HP et al. Localization of isoprenylated antigen of hepatitis delta virus by anti-farnesyl antibodies. 1999 J. Gen. Virol. pmid:9934689
Weissmann N et al. Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction. 1999 Am. J. Physiol. pmid:9887060
Niv H et al. Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies. 1999 J. Biol. Chem. pmid:9880539
Fisher JE et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874784
Shipman CM et al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. 1998 Cancer Res. pmid:9850051
Strickland CL et al. Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. 1998 Biochemistry pmid:9843427
Laezza C et al. v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9811854
Fioravanti CF and MacInnis AJ The in vitro effects of farnesol and derivatives on Hymenolepis diminuta. 1976 J. Parasitol. pmid:978365
Ferdinandy P et al. Rapid pacing-induced preconditioning is recaptured by farnesol treatment in hearts of cholesterol-fed rats: role of polyprenyl derivatives and nitric oxide. 1998 Mol. Cell. Biochem. pmid:9774182
Pei ZM et al. Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. 1998 Science pmid:9765153
Miquel K et al. Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. 1998 J. Biol. Chem. pmid:9748300
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Machida K et al. Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae. 1998 J. Bacteriol. pmid:9721283
Szilvassy Z et al. Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits. 1998 Eur. J. Pharmacol. pmid:9721042
Nishio E et al. Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. 1998 Eur. J. Pharmacol. pmid:9650858
Vaidya S et al. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. 1998 Arch. Biochem. Biophys. pmid:9647670
Bentinger M et al. Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase. 1998 Arch. Biochem. Biophys. pmid:9606952
Crick DC et al. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. 1998 J. Neurochem. pmid:9603204
Rubins JB et al. Lovastatin induces apoptosis in malignant mesothelioma cells. 1998 Am. J. Respir. Crit. Care Med. pmid:9603146
Pérez-Sala D et al. Analogs of farnesylcysteine induce apoptosis in HL-60 cells. 1998 FEBS Lett. pmid:9600259
Llorente-Cortés V et al. Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9598832
Hampton RY Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation. 1998 Curr. Opin. Lipidol. pmid:9559264
Aharonson Z et al. Stringent structural requirements for anti-Ras activity of S-prenyl analogues. 1998 Biochim. Biophys. Acta pmid:9545527
Desrosiers RR and Béliveau R Regulation by GTPgammaS of protein carboxylmethyltransferase activity in kidney brush border membranes. 1998 Arch. Biochem. Biophys. pmid:9514644
Ura H et al. Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts. 1998 Mol. Carcinog. pmid:9496909
Rajab MS et al. Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study. 1998 Planta Med. pmid:9491760
Roullet JB et al. Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. 1997 J. Hypertens. pmid:9488229
Haklai R et al. Dislodgment and accelerated degradation of Ras. 1998 Biochemistry pmid:9477957
Hohl RJ et al. Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids. 1998 Lipids pmid:9470172
Iazlovitskaia EM et al. Human leukemia CEM C-1 cells possess a high affinity binding site for farnesol. 1997 Mar-Apr Ukr. Biokhim. Zh. pmid:9463231
Kogo Y and kato J [Malignant tumor and apoptosis]. 1997 Nippon Naika Gakkai Zasshi pmid:9410963
Roullet JB et al. Farnesol inhibits L-type Ca2+ channels in vascular smooth muscle cells. 1997 J. Biol. Chem. pmid:9405427
Ghosh PM et al. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. 1997 Biochim. Biophys. Acta pmid:9398081
Goossens A and Merckx L Allergic contact dermatitis from farnesol in a deodorant. 1997 Contact Derm. pmid:9385513
Gana-Weisz M et al. The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation. 1997 Biochem. Biophys. Res. Commun. pmid:9367867
Noonan DJ and O'Brien ML A hypothetical mechanism for fat-induced rodent hepatocarcinogenesis. 1997 Adv. Exp. Med. Biol. pmid:9361820
Verzár-Petri G et al. [Determination of the composition of camomile oil]. 1976 Pharmazie pmid:935231
Andres DA et al. Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. 1997 Arch. Biochem. Biophys. pmid:9328291
Saisho Y et al. Determination of farnesyl pyrophosphate in dog and human plasma by high-performance liquid chromatography with fluorescence detection. 1997 Anal. Biochem. pmid:9324945
Nozawa Y et al. Stachybotrin C and parvisporin, novel neuritogenic compounds. II. Structure determination. 1997 J. Antibiot. pmid:9315075
Van Dessel G et al. Internalisation of short-chain isoprenyl diphosphates by chromaffin cells from bovine adrenal medulla. 1997 Biochem. Biophys. Res. Commun. pmid:9299441
Crick DC et al. Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. 1997 Biochem. Biophys. Res. Commun. pmid:9299388
Takaichi S et al. The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene. 1997 Arch. Microbiol. pmid:9297464
Zhang L et al. Isolation and characterization of a prenylcysteine lyase from bovine brain. 1997 J. Biol. Chem. pmid:9287348
Meigs TE and Simoni RD Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. 1997 Arch. Biochem. Biophys. pmid:9281305
Blazer-Yost BL et al. Protein prenylation is required for aldosterone-stimulated Na+ transport. 1997 Am. J. Physiol. pmid:9227422
Flint OP et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Toxicol. Appl. Pharmacol. pmid:9221828
Leitner JW et al. Hyperinsulinemia potentiates activation of p21Ras by growth factors. 1997 Endocrinology pmid:9112423
Crick DC et al. Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. 1997 Exp. Cell Res. pmid:9087171
Bostedor RG et al. Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. 1997 J. Biol. Chem. pmid:9083051
Denda M et al. Epidermal injury stimulates prenylation in the epidermis of hairless mice. 1997 Arch. Dermatol. Res. pmid:9049045
Tamone SL et al. Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. 1997 Gen. Comp. Endocrinol. pmid:9038249
Tisch D et al. Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. 1996 Eur. J. Biochem. pmid:9022678
King HL and Rilling HC Avian liver prenyltransferase. The role of metal in substrate binding and the orientation of substrates during catalysis. 1977 Biochemistry pmid:901755
Westfall D et al. Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. 1997 Biochem. Biophys. Res. Commun. pmid:9015362
Styczyńska B et al. [2,3-methylenefarnesenic acid derivatives as juvenile hormone analogs against housefly (Musca domestica L.)]. 1977 Wiad Parazytol pmid:899003
Carel K et al. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. 1996 J. Biol. Chem. pmid:8940037
Vogt A et al. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. 1996 Oncogene pmid:8934546
Willumsen BM et al. Novel determinants of H-Ras plasma membrane localization and transformation. 1996 Oncogene pmid:8934536
Peter MG et al. [Incorporation experiments with (3H and 14C) doubly labelled farnesols into cantharidin (author's transl)]. 1977 Helv. Chim. Acta pmid:893117
McGuire TF et al. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. 1996 J. Biol. Chem. pmid:8910319
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154
Satoh T et al. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. 1996 Life Sci. pmid:8831797
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Nishio E et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). 1996 Eur. J. Pharmacol. pmid:8773465
Koyama T et al. Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. 1996 Biochemistry pmid:8755734
Tanaka H et al. MEKA/phosducin attenuates hydrophobicity of transducin beta gamma subunits without binding to farnesyl moiety. 1996 Biochem. Biophys. Res. Commun. pmid:8687440
Crick DC et al. Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells. 1996 SAAS Bull. Biochem. Biotechnol. pmid:8652130
Keller RK et al. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Arch. Biochem. Biophys. pmid:8645011
Roullet JB et al. Farnesyl analogues inhibit vasoconstriction in animal and human arteries. 1996 J. Clin. Invest. pmid:8636420
Boisvenue RJ et al. Haemonchus contortus: effects of compounds with juvenile hormone activity on the in vitro development of infective larvae. 1977 Exp. Parasitol. pmid:862711
Meigs TE et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. 1996 J. Biol. Chem. pmid:8626470
O'Brien ML et al. Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. 1996 Carcinogenesis pmid:8625436
Parmryd I et al. Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. 1995 Eur. J. Biochem. pmid:8575428
Tachibana A et al. Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. 1996 FEBS Lett. pmid:8566226
Prashad M et al. N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors. 1993 J. Med. Chem. pmid:8496919
Gibbs JB et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. 1993 J. Biol. Chem. pmid:8463291
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
Touhara K and Prestwich GD Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs. 1993 J. Biol. Chem. pmid:8396141
Akopyan TN et al. Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15. 1994 Biochem. Biophys. Res. Commun. pmid:8297391
Kothapalli R et al. Farnesylamine: an inhibitor of farnesylation and growth of ras-transformed cells. 1993 Lipids pmid:8277827
Foster JM et al. Biosynthesis of isoprenoid compounds in Schistosoma mansoni. 1993 Mol. Biochem. Parasitol. pmid:8264731
Inoue H et al. Formation of farnesal and 3-hydroxy-2,3-dihydrofarnesal from farnesol by protoplasts of Botryococcus braunii. 1993 Biochem. Biophys. Res. Commun. pmid:8250896
Voziyan PA et al. Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. 1993 Biochem. J. pmid:8240288
Corsini A et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. 1993 Atherosclerosis pmid:8216498
Kothapalli R et al. Effects of long-chain fatty amines on the growth of ras-transformed NIH 3T3 cells. 1994 Biochem. Pharmacol. pmid:8204109
Inoue H et al. Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. 1994 Biochem. Biophys. Res. Commun. pmid:8179579
Ledoux A [Effect of a farnesol derivative on the appearance of winged females in aphaenogaster senilis (Hymenoptera, Formicoidea)]. 1976 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:817818
Caldwell GA et al. Consequences of altered isoprenylation targets on a-factor export and bioactivity. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8108401
Fukada Y et al. Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. 1994 J. Biol. Chem. pmid:8106497
Lübben M and Morand K Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. 1994 J. Biol. Chem. pmid:8063781
Kisselev OG et al. A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. 1994 J. Biol. Chem. pmid:8063769
Haug JS et al. Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. 1994 Biochim. Biophys. Acta pmid:8061045
Cox AD et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 1994 J. Biol. Chem. pmid:8034681
Correll CC et al. Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1994 J. Biol. Chem. pmid:8021239
Adany I et al. Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. 1994 Cancer Lett. pmid:8019976
Neuhüser T et al. Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. 1994 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:8014257
Tojo K et al. Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. 1994 Pharm. Res. pmid:8008705
Mallat A et al. Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. 1994 Hepatology pmid:7982659
Biermann BJ et al. Novel isoprenylated proteins identified by an expression library screen. 1994 J. Biol. Chem. pmid:7929216