| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rocha GR et al. | Effect of tt-farnesol and myricetin on in vitro biofilm formed by Streptococcus mutans and Candida albicans. | 2018 | BMC Complement Altern Med | pmid:29444673 |
| Saito K et al. | An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. | 2017 | Toxicol In Vitro | pmid:27965148 |
| Xia J et al. | In vitro inhibitory effects of farnesol and interactions between farnesol and antifungals against biofilms of Candida albicans resistant strains. | 2017 | Biofouling | pmid:28317391 |
| Cagliero C et al. | Analysis of essential oils and fragrances with a new generation of highly inert gas chromatographic columns coated with ionic liquids. | 2017 | J Chromatogr A | pmid:28343686 |
| Å piÄáková A et al. | Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions. | 2017 | Molecules | pmid:28338641 |
| Wu L et al. | Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives. | 2017 | PLoS ONE | pmid:28182780 |
| Schmukler E et al. | Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. | 2017 | PLoS ONE | pmid:28151959 |
| Zhu J et al. | Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. | 2016 | PLoS ONE | pmid:26959814 |
| Torabi S and Mo H | Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26660152 |
| Zhao Y et al. | 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. | 2016 | Eur. J. Cancer | pmid:27710830 |
| Lemaire B et al. | Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26853319 |
| Sun J et al. | A prodrug micellar carrier assembled from polymers with pendant farnesyl thiosalicylic acid moieties for improved delivery of paclitaxel. | 2016 | Acta Biomater | pmid:27422196 |
| Bandara HM et al. | Incorporation of Farnesol Significantly Increases the Efficacy of Liposomal Ciprofloxacin against Pseudomonas aeruginosa Biofilms in Vitro. | 2016 | Mol. Pharm. | pmid:27383205 |
| Inoue Y et al. | Farnesol-Induced Disruption of the Staphylococcus aureus Cytoplasmic Membrane. | 2016 | Biol. Pharm. Bull. | pmid:27150138 |
| Léger T et al. | The Metacaspase (Mca1p) Restricts O-glycosylation During Farnesol-induced Apoptosis in Candida albicans. | 2016 | Mol. Cell Proteomics | pmid:27125826 |
| Cheng HL et al. | Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways. | 2016 | Oncotarget | pmid:26848867 |
| Jung SI et al. | Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades. | 2016 | PLoS ONE | pmid:26848577 |
| Seman-Kamarulzaman AF et al. | Novel NAD+-Farnesal Dehydrogenase from Polygonum minus Leaves. Purification and Characterization of Enzyme in Juvenile Hormone III Biosynthetic Pathway in Plant. | 2016 | PLoS ONE | pmid:27560927 |
| Supuran CT | Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation. | 2015 | Expert Opin Ther Pat | pmid:26028186 |
| Rosales A et al. | Synthesis of (±)-aureol by bioinspired rearrangements. | 2015 | J. Org. Chem. | pmid:25591135 |
| Brilhante RS et al. | Histoplasma capsulatum in planktonic and biofilm forms: in vitro susceptibility to amphotericin B, itraconazole and farnesol. | 2015 | J. Med. Microbiol. | pmid:25657300 |
| Abdel-Rhman SH et al. | Effect of Tyrosol and Farnesol on Virulence and Antibiotic Resistance of Clinical Isolates of Pseudomonas aeruginosa. | 2015 | Biomed Res Int | pmid:26844228 |
| Kostoulias X et al. | Impact of a Cross-Kingdom Signaling Molecule of Candida albicans on Acinetobacter baumannii Physiology. | 2015 | Antimicrob. Agents Chemother. | pmid:26482299 |
| Hameiri-Grossman M et al. | The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth. | 2015 | Oncotarget | pmid:26393682 |
| Lopez-Medina E et al. | Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. | 2015 | PLoS Pathog. | pmid:26313907 |
| Joo JH et al. | Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells. | 2015 | Biochem. Pharmacol. | pmid:26275811 |
| Krause J et al. | Prostaglandin E2 from Candida albicans Stimulates the Growth of Staphylococcus aureus in Mixed Biofilms. | 2015 | PLoS ONE | pmid:26262843 |
| Mogen AB et al. | Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms. | 2015 | PLoS ONE | pmid:26222384 |
| Hargarten JC et al. | Candida albicans Quorum Sensing Molecules Stimulate Mouse Macrophage Migration. | 2015 | Infect. Immun. | pmid:26195556 |
| Stoddart CA et al. | Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque. | 2015 | Antimicrob. Agents Chemother. | pmid:25941222 |
| de Salas F et al. | Quorum-Sensing Mechanisms Mediated by Farnesol in Ophiostoma piceae: Effect on Secretion of Sterol Esterase. | 2015 | Appl. Environ. Microbiol. | pmid:25888179 |
| Badar T et al. | Phase I study of S-trans, trans-farnesylthiosalicylic acid (salirasib), a novel oral RAS inhibitor in patients with refractory hematologic malignancies. | 2015 | Clin Lymphoma Myeloma Leuk | pmid:25795639 |
| Zhang W et al. | Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission. | 2015 | Pharm. Res. | pmid:25794967 |
| Leonhardt I et al. | The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. | 2015 | MBio | pmid:25784697 |
| Horev B et al. | pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence. | 2015 | ACS Nano | pmid:25661192 |
| De Loof A | The essence of female-male physiological dimorphism: differential Ca2+-homeostasis enabled by the interplay between farnesol-like endogenous sesquiterpenoids and sex-steroids? The Calcigender paradigm. | 2015 | Gen. Comp. Endocrinol. | pmid:25540913 |
| Léger T et al. | The metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans. | 2015 | Mol. Cell Proteomics | pmid:25348831 |
| Katragkou A et al. | In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms. | 2015 | J. Antimicrob. Chemother. | pmid:25288679 |
| Strube-Bloss MF et al. | Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris. | 2015 | PLoS ONE | pmid:26340263 |
| Scheman A et al. | European Directive fragrances in natural products. | 2014 Mar-Apr | Dermatitis | pmid:24603515 |
| Chen M et al. | Use of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasion. | 2014 | PLoS ONE | pmid:24587105 |
| Ha J et al. | Determination of E,E-farnesol in Makgeolli (rice wine) using dynamic headspace sampling and stir bar sorptive extraction coupled with gas chromatography-mass spectrometry. | 2014 | Food Chem | pmid:24001815 |
| Bhattacharyya S et al. | Sol-gel silica controlled release thin films for the inhibition of methicillin-resistant Staphylococcus aureus. | 2014 | Biomaterials | pmid:24099711 |
| Matsuzawa T et al. | EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium. | 2014 | J. Invest. Dermatol. | pmid:24384694 |
| Ronderos DS et al. | Farnesol-detecting olfactory neurons in Drosophila. | 2014 | J. Neurosci. | pmid:24623773 |
| Lu Y et al. | Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24449897 |
| Sakane C et al. | Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24406160 |
| Sabra A et al. | Host-pathogen interaction and signaling molecule secretion are modified in the dpp3 knockout mutant of Candida lusitaniae. | 2014 | Infect. Immun. | pmid:24191303 |
| Aizman E et al. | Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis through suppressed release of inflammatory cytokines. | 2014 | Clin. Exp. Immunol. | pmid:24215151 |
| Neeman R et al. | Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation. | 2014 | Dig. Dis. Sci. | pmid:24942325 |
| Zhang X et al. | Nanomicellar carriers for targeted delivery of anticancer agents. | 2014 | Ther Deliv | pmid:24341817 |
| Ling Y et al. | Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents. | 2014 | Bioorg. Med. Chem. | pmid:24300920 |
| Makovski V et al. | Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway. | 2014 | Cell Death Dis | pmid:25476905 |
| Okamoto S et al. | Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions. | 2014 | Cell Death Dis | pmid:25393473 |
| Goldshmit Y et al. | Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma. | 2014 | Oncotarget | pmid:25261371 |
| Zhang X et al. | Reduction-sensitive dual functional nanomicelles for improved delivery of paclitaxel. | 2014 | Bioconjug. Chem. | pmid:25121577 |
| Zhang X et al. | PEG-farnesyl thiosalicylic acid telodendrimer micelles as an improved formulation for targeted delivery of paclitaxel. | 2014 | Mol. Pharm. | pmid:24987803 |
| Ilayaraja R et al. | Evaluating the binding efficiency of pheromone binding protein with its natural ligand using molecular docking and fluorescence analysis. | 2014 | Sci Rep | pmid:24903953 |
| Chen Y et al. | Targeted delivery of curcumin to tumors via PEG-derivatized FTS-based micellar system. | 2014 | AAPS J | pmid:24706375 |
| Schmukler E et al. | Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death. | 2014 | Oncotarget | pmid:24368422 |
| Cotoras M et al. | Farnesol induces apoptosis-like phenotype in the phytopathogenic fungus Botrytis cinerea. | 2013 Jan-Feb | Mycologia | pmid:22962358 |
| Alves FR et al. | Biofilm biomass disruption by natural substances with potential for endodontic use. | 2013 Jan-Feb | Braz Oral Res | pmid:23306623 |
| de Oliveira Júnior WM et al. | Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice. | 2013 | Fundam Clin Pharmacol | pmid:22340189 |
| Cordeiro RA et al. | Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol. | 2013 | Med. Mycol. | pmid:22712455 |
| Farag MA and Al-Mahdy DA | Comparative study of the chemical composition and biological activities of Magnolia grandiflora and Magnolia virginiana flower essential oils. | 2013 | Nat. Prod. Res. | pmid:22690913 |
| Zhang X et al. | PEG-farnesylthiosalicylate conjugate as a nanomicellar carrier for delivery of paclitaxel. | 2013 | Bioconjug. Chem. | pmid:23425093 |
| Brilhante RS et al. | Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii. | 2013 | Antimicrob. Agents Chemother. | pmid:23459491 |
| Mor A et al. | Immunomodulatory properties of farnesoids: the new steroids? | 2013 | Curr. Med. Chem. | pmid:23432580 |
| Langford ML et al. | Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death. | 2013 | Eukaryotic Cell | pmid:23873867 |
| Schmukler E et al. | Ras inhibition enhances autophagy, which partially protects cells from death. | 2013 | Oncotarget | pmid:23847721 |
| Wang C et al. | Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. | 2013 | Metab. Eng. | pmid:23608473 |
| Cho SW et al. | Positive regulation of osteogenesis by bile acid through FXR. | 2013 | J. Bone Miner. Res. | pmid:23609136 |
| Gouveia V et al. | Di- and sesquiterpenoids from Cystoseira genus: structure, intra-molecular transformations and biological activity. | 2013 | Mini Rev Med Chem | pmid:23621654 |
| Rivera-Perez C et al. | Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes. | 2013 | Insect Biochem. Mol. Biol. | pmid:23639754 |
| Jones S et al. | β-ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. | 2013 | Nutr Cancer | pmid:23659452 |
| Szűcs G et al. | Cardioprotection by farnesol: role of the mevalonate pathway. | 2013 | Cardiovasc Drugs Ther | pmid:23673412 |
| Charette N et al. | Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms. | 2013 | Cell Death Dis | pmid:23348585 |
| Schmukler E et al. | Ras inhibition enhances autophagy, which partially protects cells from death. | 2013 | Oncotarget | pmid:23370967 |
| Kraitzer A et al. | Mechanisms of antiproliferative drug release from bioresorbable porous structures. | 2013 | J Biomed Mater Res A | pmid:23065767 |
| Barkan B et al. | Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis. | 2013 | Oncotarget | pmid:23530091 |
| Faigenbaum R et al. | Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. | 2013 | Oncotarget | pmid:23530112 |
| Xu H et al. | Glucanase induces filamentation of the fungal pathogen Candida albicans. | 2013 | PLoS ONE | pmid:23737947 |
| Nunes PM et al. | Study of trans-trans farnesol effect on hyphae formation by Yarrowia lipolytica. | 2013 | Bioprocess Biosyst Eng | pmid:23715764 |
| Nyati P et al. | Farnesyl phosphatase, a Corpora allata enzyme involved in juvenile hormone biosynthesis in Aedes aegypti. | 2013 | PLoS ONE | pmid:23940797 |
| Onono F et al. | Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. | 2013 | J. Biol. Chem. | pmid:23908355 |
| Schokoroy S et al. | Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death. | 2013 | PLoS ONE | pmid:24086490 |
| Kloog Y et al. | Ras chaperones: new targets for cancer and immunotherapy. | 2013 | Enzymes | pmid:25033809 |
| Pfister C et al. | Detection and quantification of farnesol-induced apoptosis in difficult primary cell cultures by TaqMan protein assay. | 2013 | Apoptosis | pmid:23315006 |
| Cerca N et al. | Farnesol induces cell detachment from established S. epidermidis biofilms. | 2013 | J. Antibiot. | pmid:23549353 |
| Kuete V and Efferth T | Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol. | 2013 | Pharmazie | pmid:23923645 |
| Alves FR et al. | Antibiofilm and antibacterial activities of farnesol and xylitol as potential endodontic irrigants. | 2013 | Braz Dent J | pmid:23969910 |
| Lazzerini PE et al. | Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. | 2013 | Joint Bone Spine | pmid:22999910 |
| Mashiach-Farkash E et al. | Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. | 2012 | Oncotarget | pmid:22776759 |
| András IE et al. | Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22490665 |
| Mor A et al. | Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production. | 2012 | Inflammation | pmid:22688643 |
| Lichtor PA and Miller SJ | Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation. | 2012 | Nat Chem | pmid:23174978 |
| Jamalian A et al. | Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. | 2012 | J Mycol Med | pmid:23518164 |
| Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
| Wartenberg D et al. | Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. | 2012 | J Proteomics | pmid:22634043 |
| Yu LH et al. | Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. | 2012 | Antimicrob. Agents Chemother. | pmid:22106223 |