2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Authors Title Published Journal PubMed Link
Hartmann MA et al. Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. 2000 Biochem. Soc. Trans. pmid:11171211
Schlitzer M and Dahse HM Structure activity relationship of antiproliferative N-acyl-beta-alanine amides. 2000 Nov-Dec Anticancer Res. pmid:11205283
Hanley K et al. Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. 2001 J. Lipid Res. pmid:11254751
Fayard E et al. Xol INXS: role of the liver X and the farnesol X receptors. 2001 Curr. Opin. Lipidol. pmid:11264982
Rosado JA and Sage SO Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. 2001 J. Biol. Chem. pmid:11278479
Daily D et al. Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways. 2001 J. Biol. Chem. pmid:11290748
Clausen VA et al. Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase. 2001 Biochemistry pmid:11300771
Wright MM et al. Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. 2001 J. Biol. Chem. pmid:11306571
McCaffery AR and Highnam KC Effects of corpus aliatum hormone and its mimics on the activity of the cerebral neurosecretory system of Locusta migratoria migratorioides R. & F. 1975 Gen. Comp. Endocrinol. pmid:1132652
Hornby JM et al. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. 2001 Appl. Environ. Microbiol. pmid:11425711
Cheng QF et al. Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. 2001 Exp. Eye Res. pmid:11446774
Nah J et al. Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation. 2001 Plant Cell Physiol. pmid:11522913
Rakhit RD et al. Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury. 2001 Biochem. Biophys. Res. Commun. pmid:11527399
Mizukami Y et al. Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells. 2001 Biochem. Biophys. Res. Commun. pmid:11594773
Villegas LF et al. (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids. 2001 J. Nat. Prod. pmid:11678668
Karussis D et al. The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis. 2001 J. Neuroimmunol. pmid:11694313
Kim SY et al. Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism. 2001 Metab. Clin. Exp. pmid:11699057
Cantrell CL et al. Antimycobacterial plant terpenoids. 2001 Planta Med. pmid:11731906
Sari R et al. Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi. 2001 Eur. J. Pharmacol. pmid:11734192
Katzav A et al. Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). 2001 Clin. Exp. Immunol. pmid:11737078
Inoue I et al. Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. 2002 Biochem. Biophys. Res. Commun. pmid:11779144
Gana-Weisz M et al. The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance. 2002 Clin. Cancer Res. pmid:11839677
Mizukami Y [Oleylamine (long-chain fatty amine)-induced cell death through MAP kinase pathways in human pancreatic cancer cells]. 2002 Hokkaido Igaku Zasshi pmid:11868368
Radetich B and Corey EJ A general stereocontrolled, convergent synthesis of oligoprenols that parallels the biosynthetic pathway. 2002 J. Am. Chem. Soc. pmid:11890779
Teal PE Effects of allatotropin and allatostatin on in vitro production of juvenile hormones by the corpora allata of virgin females of the moths of Heliothis virescens and Manduca sexta. 2002 Peptides pmid:11897385
Ownby SE and Hohl RJ Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. 2002 Lipids pmid:11908910
Smalley KS and Eisen TG Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. 2002 Int. J. Cancer pmid:11920610
Hamada M et al. Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells. 2002 FEBS Lett. pmid:11943160
Takahashi N et al. Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. 2002 FEBS Lett. pmid:11943173
Kim S et al. Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism. 2002 Bioorg. Med. Chem. Lett. pmid:11958988
George J et al. Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. 2002 Circulation pmid:12021230
Lagace TA et al. Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. 2002 Mol. Cell. Biol. pmid:12052891
Raner GM et al. Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes. 2002 Biochem. Biophys. Res. Commun. pmid:12054554
Akiyama H et al. Actions of farnesol and xylitol against Staphylococcus aureus. 2002 Chemotherapy pmid:12138327
Du Y and Wiemer DF Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis. 2002 J. Org. Chem. pmid:12153272
Meinhardt G et al. Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. 2002 Anticancer Drugs pmid:12187329
Chakrabarti D et al. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum. 2002 J. Biol. Chem. pmid:12194969
Ludolph B et al. Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B. 2002 Chembiochem pmid:12210992
Kato N et al. Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. 2002 J. Neurol. Sci. pmid:12220695
Goodwin TE et al. African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol. 2002 J. Nat. Prod. pmid:12350155
Frenkel J et al. Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. 2002 Arthritis Rheum. pmid:12384940
Ward SM et al. TGFbeta regulates the expression of G alpha(i2) via an effect on the localization of ras. 2002 J. Mol. Cell. Cardiol. pmid:12392895
Binet P et al. [Farnesol and neuroleptics. I. Reinforcement by farnesol of the experimental cataleptigenic effect of neuroleptics]. 1975 Ann Pharm Fr pmid:1239975
Ramage G et al. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. 2002 Appl. Environ. Microbiol. pmid:12406738
Binet P et al. [Farnesol and neuroleptics. II. Action of farnesol, alone or associated with a neuroleptic, on the stereotypies induced in the rat by amphetamine]. 1975 Jun-Jul Ann Pharm Fr pmid:1241259
Wright MM and McMaster CR Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis. 2002 Biol. Res. pmid:12415740
Still K et al. Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. 2003 Calcif. Tissue Int. pmid:12457261
Winn LM and Wells PG Evidence for Ras-dependent signal transduction in phenytoin teratogenicity. 2002 Toxicol. Appl. Pharmacol. pmid:12460742
Schnee C et al. The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. 2002 Plant Physiol. pmid:12481088
Koo H et al. Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. 2002 Oral Microbiol. Immunol. pmid:12485324