| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Journe F et al. | Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. | 2008 | Breast Cancer Res. Treat. | pmid:17333335 |
| Wegner Z | Insecticidal action of "Cyklopren" against mosquitoes in minute artificial water containers. | 1984 | Bull Inst Marit Trop Med Gdynia | pmid:6545940 |
| Maciejewska J | The influence of the Polish juvenoid Cyklopren on the development and survival of Xenopsylla cheopis (Rothschild, 1903) (Siphonaptera)--the principal vector of plague in man. | 1986 | Bull Inst Marit Trop Med Gdynia | pmid:3440169 |
| Azerad R and Cyrot MO | [Synthesis of 2 dihydrofarnesyl-naphthoquinones related to the vitamin K2(45)H of Mycobacterium phlei]. | 1965 | Bull Soc Chim Fr | pmid:5858127 |
| Ledoux A | [Effect of a farnesol derivative on the appearance of winged females in aphaenogaster senilis (Hymenoptera, Formicoidea)]. | 1976 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:817818 |
| Still K et al. | Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. | 2003 | Calcif. Tissue Int. | pmid:12457261 |
| Braun PC | The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. | 2005 | Can. J. Microbiol. | pmid:16234870 |
| Shanta CS and Meerovitch E | Specific inhibition of morphogenesis in Trichinella spiralis by insect juvenile hormone mimics. | 1970 | Can. J. Zool. | pmid:5475084 |
| Tsimberidou AM et al. | Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. | 2010 | Cancer Chemother. Pharmacol. | pmid:19484470 |
| Haklai R et al. | Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. | 2008 | Cancer Chemother. Pharmacol. | pmid:17909812 |
| Rao CV et al. | Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis. | 2002 | Cancer Detect. Prev. | pmid:12507226 |
| Au-Yeung KK et al. | Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. | 2008 | Cancer Invest. | pmid:18608213 |
| Joo JH and Jetten AM | Molecular mechanisms involved in farnesol-induced apoptosis. | 2010 | Cancer Lett. | pmid:19520495 |
| Mo H et al. | Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas. | 2000 | Cancer Lett. | pmid:10936674 |
| Yazlovitskaya EM and Melnykovych G | Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. | 1995 | Cancer Lett. | pmid:7874691 |
| Adany I et al. | Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. | 1994 | Cancer Lett. | pmid:8019976 |
| McAnally JA et al. | Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. | 2003 | Cancer Lett. | pmid:14643448 |
| Shipman CM et al. | The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | 1998 | Cancer Res. | pmid:9850051 |
| Blum R et al. | Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). | 2007 | Cancer Res. | pmid:17409441 |
| Zhang L and Hill RP | Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. | 2007 | Cancer Res. | pmid:17699784 |
| Joo JH et al. | Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. | 2007 | Cancer Res. | pmid:17699800 |
| Blum R et al. | Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. | 2005 | Cancer Res. | pmid:15705901 |
| Eskens FA et al. | Farnesyl transferase inhibitors: current developments and future perspectives. | 2000 | Cancer Treat. Rev. | pmid:11006134 |
| Ong TP et al. | Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. | 2006 | Carcinogenesis | pmid:16332721 |
| O'Brien ML et al. | Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. | 1996 | Carcinogenesis | pmid:8625436 |
| Szűcs G et al. | Cardioprotection by farnesol: role of the mevalonate pathway. | 2013 | Cardiovasc Drugs Ther | pmid:23673412 |
| Pando R et al. | The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. | 2010 Mar-Apr | Cardiovasc. Pathol. | pmid:19144546 |
| RodrÃguez C et al. | Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. | 2009 | Cardiovasc. Res. | pmid:19406911 |
| Yoo S et al. | Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. | 2011 | Caries Res. | pmid:21720161 |
| Søgaard M et al. | A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. | 1994 | Cell | pmid:7923363 |
| Aronheim A et al. | Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | 1994 | Cell | pmid:7923364 |
| Forman BM et al. | Identification of a nuclear receptor that is activated by farnesol metabolites. | 1995 | Cell | pmid:7774010 |
| Zoccarato F et al. | The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. | 2003 | Cell Calcium | pmid:12618148 |
| Shapira S et al. | The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. | 2007 | Cell Death Differ. | pmid:17096025 |
| Amos S et al. | Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells. | 2006 | Cell Death Differ. | pmid:16239932 |
| Shalom-Feuerstein R et al. | Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. | 2004 | Cell Death Differ. | pmid:14576773 |
| Goldberg L et al. | FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. | 2012 | Cell Death Dis | pmid:22419113 |
| Charette N et al. | Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms. | 2013 | Cell Death Dis | pmid:23348585 |
| Makovski V et al. | Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway. | 2014 | Cell Death Dis | pmid:25476905 |
| Okamoto S et al. | Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions. | 2014 | Cell Death Dis | pmid:25393473 |
| Lee J et al. | Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. | 2010 | Cell Res. | pmid:20603646 |
| Houten SM et al. | Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. | 2003 | Cell. Mol. Life Sci. | pmid:12861380 |
| Iguchi T et al. | Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. | 2003 | Cell. Signal. | pmid:12742232 |
| Smejkal V et al. | [Antiulcerous effect of various esters of farnesylacetic acid on the gastric mucosa in guinea pigs and rats]. | 1966 | Cesk Gastroenterol Vyz | pmid:5934910 |
| Shchepin R et al. | Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. | 2003 | Chem. Biol. | pmid:12954333 |
| Shchepin R et al. | Biologically active fluorescent farnesol analogs. | 2005 | Chem. Biol. | pmid:15975508 |
| Khan R and Sultana S | Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. | 2011 | Chem. Biol. Interact. | pmid:21453689 |
| Endo S et al. | Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. | 2011 | Chem. Biol. Interact. | pmid:21187079 |
| Qamar W and Sultana S | Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention. | 2008 | Chem. Biol. Interact. | pmid:18793622 |
| Moya M et al. | Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. | 2010 | Chem. Biol. Interact. | pmid:20079722 |
| Horn TL et al. | Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. | 2005 | Chem. Biol. Interact. | pmid:15840382 |
| Bondar OP et al. | Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. | 1994 | Chem. Phys. Lipids | pmid:7820904 |
| Ludolph B et al. | Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B. | 2002 | Chembiochem | pmid:12210992 |
| Raptis C et al. | Acid-catalyzed cyclization of terpenes under homogeneous and heterogeneous conditions as probed through stereoisotopic studies: a concerted process with competing preorganized chair and boat transition states. | 2009 | Chemistry | pmid:19780112 |
| Akiyama H et al. | Actions of farnesol and xylitol against Staphylococcus aureus. | 2002 | Chemotherapy | pmid:12138327 |
| Luxová A et al. | Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. | 2004 | Chirality | pmid:15034905 |
| George J et al. | Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. | 2002 | Circulation | pmid:12021230 |
| Badar T et al. | Phase I study of S-trans, trans-farnesylthiosalicylic acid (salirasib), a novel oral RAS inhibitor in patients with refractory hematologic malignancies. | 2015 | Clin Lymphoma Myeloma Leuk | pmid:25795639 |
| Buffatti G | [Geranyl farnesyl acetate in the treatment of gastroenteritis in the infant]. | 1965 | Clin Pediatr (Bologna) | pmid:5882341 |
| Gana-Weisz M et al. | The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance. | 2002 | Clin. Cancer Res. | pmid:11839677 |
| Bachireddy P et al. | Getting at MYC through RAS. | 2005 | Clin. Cancer Res. | pmid:15958607 |
| Yaari S et al. | Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. | 2005 | Clin. Cancer Res. | pmid:15958613 |
| Barkan B et al. | The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. | 2006 | Clin. Cancer Res. | pmid:17000690 |
| Aizman E et al. | Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis through suppressed release of inflammatory cytokines. | 2014 | Clin. Exp. Immunol. | pmid:24215151 |
| Katzav A et al. | Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). | 2001 | Clin. Exp. Immunol. | pmid:11737078 |
| da Silva Morais A et al. | Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats. | 2008 | Clin. Sci. | pmid:17678500 |
| Abbasnezhad H et al. | Two different mechanisms for adhesion of Gram-negative bacterium, Pseudomonas fluorescens LP6a, to an oil-water interface. | 2008 | Colloids Surf B Biointerfaces | pmid:17997081 |
| Fioravanti CF and MacInnis AJ | The identification and characterization of a prenoid constituent (farnesol) of Hymenolepis diminuta (Cestoda). | 1977 | Comp. Biochem. Physiol., B | pmid:299634 |
| Patrassi G | [The relationship between collagenosis and rheumatic disease]. | 1966 | Concours Med | pmid:5904237 |
| Goossens A and Merckx L | Allergic contact dermatitis from farnesol in a deodorant. | 1997 | Contact Derm. | pmid:9385513 |
| Frosch PJ et al. | Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. | 2005 | Contact Derm. | pmid:15859993 |
| Frosch PJ et al. | Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products. | 2005 | Contact Derm. | pmid:15859994 |
| Hemmer W et al. | Axillary dermatitis from farnesol in a deodorant. | 2000 | Contact Derm. | pmid:10727172 |
| Schnuch A et al. | Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. | 2004 | Contact Derm. | pmid:15153123 |
| Mor A et al. | Immunomodulatory properties of farnesoids: the new steroids? | 2013 | Curr. Med. Chem. | pmid:23432580 |
| Gomes FI et al. | Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis. | 2009 | Curr. Microbiol. | pmid:19365686 |
| Gomes F et al. | Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. | 2011 | Curr. Microbiol. | pmid:21800262 |
| Hampton RY | Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation. | 1998 | Curr. Opin. Lipidol. | pmid:9559264 |
| Fayard E et al. | Xol INXS: role of the liver X and the farnesol X receptors. | 2001 | Curr. Opin. Lipidol. | pmid:11264982 |
| Hogan DA and Muhlschlegel FA | Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. | 2011 | Curr. Opin. Microbiol. | pmid:22014725 |
| Fuchs BB and Mylonakis E | Using non-mammalian hosts to study fungal virulence and host defense. | 2006 | Curr. Opin. Microbiol. | pmid:16814595 |
| Gilpin S and Maibach H | Allergic contact dermatitis caused by farnesol: clinical relevance. | 2010 | Cutan Ocul Toxicol | pmid:20858058 |
| Décanis N et al. | Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. | 2009 | Cytokine | pmid:19121950 |
| Scheman A et al. | European Directive fragrances in natural products. | 2014 Mar-Apr | Dermatitis | pmid:24603515 |
| Thorpe JL et al. | Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. | 2004 | Dev. Cell | pmid:14960282 |
| Neeman R et al. | Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation. | 2014 | Dig. Dis. Sci. | pmid:24942325 |
| Oron T et al. | Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid. | 2012 | Dig. Dis. Sci. | pmid:21901261 |
| Zvibel I et al. | The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. | 2008 | Dig. Dis. Sci. | pmid:17934818 |
| Egorov IA et al. | [Farnesol in brandy]. | 1967 Mar-Apr | Dokl. Akad. Nauk SSSR | pmid:5623628 |
| Gefarnate. | 1968 | Drug Ther Bull | pmid:5722353 | |
| Ohguro H et al. | Carboxyl methylation and farnesylation of transducin gamma-subunit synergistically enhance its coupling with metarhodopsin II. | 1991 | EMBO J. | pmid:1935895 |
| Shearer AG and Hampton RY | Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. | 2005 | EMBO J. | pmid:15635451 |
| Berstein LM et al. | New approaches to the understanding of tamoxifen action and resistance. | 2003 | Endocr. Relat. Cancer | pmid:12790788 |
| Leitner JW et al. | Hyperinsulinemia potentiates activation of p21Ras by growth factors. | 1997 | Endocrinology | pmid:9112423 |
| Bhavnani BR and Woolever CA | Formation of steroids by the pregnant mare. VI. Metabolism of [14C]farnesyl pyrophosphate and [3H]dehydroepiandrosterone injected into the fetus. | 1978 | Endocrinology | pmid:155006 |
| Bellahcène A et al. | Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. | 2007 Mar-Apr | Endothelium | pmid:17497369 |
| Menn JJ and Pallow FM | Development of morphogenetic agents in insect control. | 1975 | Environ Lett | pmid:1091483 |
| Kloog Y et al. | Ras chaperones: new targets for cancer and immunotherapy. | 2013 | Enzymes | pmid:25033809 |
| Langford ML et al. | Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death. | 2013 | Eukaryotic Cell | pmid:23873867 |
| Deveau A et al. | Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. | 2010 | Eukaryotic Cell | pmid:20118211 |