| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
2E,6E-farnesol
2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.
Cross Reference
Introduction
To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2E,6E-farnesol?
2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol
PubChem Associated disorders and diseases
What pathways are associated with 2E,6E-farnesol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2E,6E-farnesol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 2E,6E-farnesol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2E,6E-farnesol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2E,6E-farnesol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prashad M et al. | N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors. | 1993 | J. Med. Chem. | pmid:8496919 |
| Foster JM et al. | Biosynthesis of isoprenoid compounds in Schistosoma mansoni. | 1993 | Mol. Biochem. Parasitol. | pmid:8264731 |
| Inoue H et al. | Formation of farnesal and 3-hydroxy-2,3-dihydrofarnesal from farnesol by protoplasts of Botryococcus braunii. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8250896 |
| Søgaard M et al. | A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. | 1994 | Cell | pmid:7923363 |
| Biermann BJ et al. | Novel isoprenylated proteins identified by an expression library screen. | 1994 | J. Biol. Chem. | pmid:7929216 |
| Munro E et al. | Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. | 1994 | Eur. J. Clin. Invest. | pmid:7890015 |
| Tojo K et al. | Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. | 1994 | Pharm. Res. | pmid:8008705 |
| Fukada Y et al. | Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. | 1994 | J. Biol. Chem. | pmid:8106497 |
| Caldwell GA et al. | Consequences of altered isoprenylation targets on a-factor export and bioactivity. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8108401 |
| Kothapalli R et al. | Effects of long-chain fatty amines on the growth of ras-transformed NIH 3T3 cells. | 1994 | Biochem. Pharmacol. | pmid:8204109 |
| Inoue H et al. | Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8179579 |
| Bondar OP et al. | Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. | 1994 | Chem. Phys. Lipids | pmid:7820904 |
| Aronheim A et al. | Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | 1994 | Cell | pmid:7923364 |
| Haug JS et al. | Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. | 1994 | Biochim. Biophys. Acta | pmid:8061045 |
| Kisselev OG et al. | A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. | 1994 | J. Biol. Chem. | pmid:8063769 |
| Lübben M and Morand K | Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. | 1994 | J. Biol. Chem. | pmid:8063781 |
| Neuhüser T et al. | Responsiveness of the adult cricket (Gryllus bimaculatus and Acheta domesticus) retrocerebral complex to allatostatin-1 from a cockroach, Diploptera punctata. | 1994 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:8014257 |
| Adany I et al. | Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. | 1994 | Cancer Lett. | pmid:8019976 |
| Correll CC et al. | Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1994 | J. Biol. Chem. | pmid:8021239 |
| Mallat A et al. | Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. | 1994 | Hepatology | pmid:7982659 |
| Cox AD et al. | The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. | 1994 | J. Biol. Chem. | pmid:8034681 |
| Akopyan TN et al. | Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8297391 |
| Kisselev O et al. | Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. | 1995 | J. Biol. Chem. | pmid:7592699 |
| Corsini A et al. | Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. | 1995 | Am. J. Cardiol. | pmid:7604791 |
| Crick DC et al. | Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7794274 |
| Meigs TE et al. | Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. | 1995 | Exp. Cell Res. | pmid:7641798 |
| Yazlovitskaya EM and Melnykovych G | Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. | 1995 | Cancer Lett. | pmid:7874691 |
| Forman BM et al. | Identification of a nuclear receptor that is activated by farnesol metabolites. | 1995 | Cell | pmid:7774010 |
| Voziyan PA et al. | Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626062 |
| Marom M et al. | Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. | 1995 | J. Biol. Chem. | pmid:7673206 |
| Gilbert BA et al. | Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. | 1995 | Biochemistry | pmid:7696255 |
| Fliesler SJ and Keller RK | Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7763243 |
| Marciano D et al. | Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth. | 1995 | J. Med. Chem. | pmid:7731012 |
| Epand RM et al. | Lipid-mediated a-factor interactions with artificial membranes. | 1995 | Meth. Enzymol. | pmid:7651149 |
| Parmryd I et al. | Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. | 1995 | Eur. J. Biochem. | pmid:8575428 |
| Meigs TE et al. | Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. | 1996 | J. Biol. Chem. | pmid:8626470 |
| Tachibana A et al. | Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. | 1996 | FEBS Lett. | pmid:8566226 |
| Satoh T et al. | The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. | 1996 | Life Sci. | pmid:8831797 |
| Crick DC et al. | Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells. | 1996 | SAAS Bull. Biochem. Biotechnol. | pmid:8652130 |
| Tanaka H et al. | MEKA/phosducin attenuates hydrophobicity of transducin beta gamma subunits without binding to farnesyl moiety. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687440 |
| Nishio E et al. | 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). | 1996 | Eur. J. Pharmacol. | pmid:8773465 |
| Carel K et al. | Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. | 1996 | J. Biol. Chem. | pmid:8940037 |
| Willumsen BM et al. | Novel determinants of H-Ras plasma membrane localization and transformation. | 1996 | Oncogene | pmid:8934536 |
| Vogt A et al. | Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. | 1996 | Oncogene | pmid:8934546 |
| Tisch D et al. | Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. | 1996 | Eur. J. Biochem. | pmid:9022678 |
| McGuire TF et al. | Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. | 1996 | J. Biol. Chem. | pmid:8910319 |
| Miquel K et al. | Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780704 |
| Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
| Koyama T et al. | Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. | 1996 | Biochemistry | pmid:8755734 |
| Umetani N et al. | Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. | 1996 | Biochim. Biophys. Acta | pmid:8908154 |
| Roullet JB et al. | Farnesyl analogues inhibit vasoconstriction in animal and human arteries. | 1996 | J. Clin. Invest. | pmid:8636420 |
| O'Brien ML et al. | Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. | 1996 | Carcinogenesis | pmid:8625436 |
| Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |
| Roullet JB et al. | Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. | 1997 | J. Hypertens. | pmid:9488229 |
| Roullet JB et al. | Farnesol inhibits L-type Ca2+ channels in vascular smooth muscle cells. | 1997 | J. Biol. Chem. | pmid:9405427 |
| Kogo Y and kato J | [Malignant tumor and apoptosis]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9410963 |
| Nozawa Y et al. | Stachybotrin C and parvisporin, novel neuritogenic compounds. II. Structure determination. | 1997 | J. Antibiot. | pmid:9315075 |
| Saisho Y et al. | Determination of farnesyl pyrophosphate in dog and human plasma by high-performance liquid chromatography with fluorescence detection. | 1997 | Anal. Biochem. | pmid:9324945 |
| Noonan DJ and O'Brien ML | A hypothetical mechanism for fat-induced rodent hepatocarcinogenesis. | 1997 | Adv. Exp. Med. Biol. | pmid:9361820 |
| Gana-Weisz M et al. | The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9367867 |
| Goossens A and Merckx L | Allergic contact dermatitis from farnesol in a deodorant. | 1997 | Contact Derm. | pmid:9385513 |
| Meigs TE and Simoni RD | Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. | 1997 | Arch. Biochem. Biophys. | pmid:9281305 |
| Takaichi S et al. | The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene. | 1997 | Arch. Microbiol. | pmid:9297464 |
| Crick DC et al. | Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299388 |
| Van Dessel G et al. | Internalisation of short-chain isoprenyl diphosphates by chromaffin cells from bovine adrenal medulla. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9299441 |
| Blazer-Yost BL et al. | Protein prenylation is required for aldosterone-stimulated Na+ transport. | 1997 | Am. J. Physiol. | pmid:9227422 |
| Crick DC et al. | Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. | 1997 | Exp. Cell Res. | pmid:9087171 |
| Leitner JW et al. | Hyperinsulinemia potentiates activation of p21Ras by growth factors. | 1997 | Endocrinology | pmid:9112423 |
| Flint OP et al. | Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9221828 |
| Denda M et al. | Epidermal injury stimulates prenylation in the epidermis of hairless mice. | 1997 | Arch. Dermatol. Res. | pmid:9049045 |
| Tamone SL et al. | Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. | 1997 | Gen. Comp. Endocrinol. | pmid:9038249 |
| Westfall D et al. | Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9015362 |
| Ghosh PM et al. | Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. | 1997 | Biochim. Biophys. Acta | pmid:9398081 |
| Zhang L et al. | Isolation and characterization of a prenylcysteine lyase from bovine brain. | 1997 | J. Biol. Chem. | pmid:9287348 |
| Andres DA et al. | Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. | 1997 | Arch. Biochem. Biophys. | pmid:9328291 |
| Iazlovitskaia EM et al. | Human leukemia CEM C-1 cells possess a high affinity binding site for farnesol. | 1997 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9463231 |
| Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
| Hohl RJ et al. | Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids. | 1998 | Lipids | pmid:9470172 |
| Aharonson Z et al. | Stringent structural requirements for anti-Ras activity of S-prenyl analogues. | 1998 | Biochim. Biophys. Acta | pmid:9545527 |
| Ura H et al. | Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts. | 1998 | Mol. Carcinog. | pmid:9496909 |
| Haklai R et al. | Dislodgment and accelerated degradation of Ras. | 1998 | Biochemistry | pmid:9477957 |
| Hampton RY | Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation. | 1998 | Curr. Opin. Lipidol. | pmid:9559264 |
| Desrosiers RR and Béliveau R | Regulation by GTPgammaS of protein carboxylmethyltransferase activity in kidney brush border membranes. | 1998 | Arch. Biochem. Biophys. | pmid:9514644 |
| Miquel K et al. | Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. | 1998 | J. Biol. Chem. | pmid:9748300 |
| Laezza C et al. | v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9811854 |
| Ferdinandy P et al. | Rapid pacing-induced preconditioning is recaptured by farnesol treatment in hearts of cholesterol-fed rats: role of polyprenyl derivatives and nitric oxide. | 1998 | Mol. Cell. Biochem. | pmid:9774182 |
| Shipman CM et al. | The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | 1998 | Cancer Res. | pmid:9850051 |
| Aboushadi N and Krisans SK | Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. | 1998 | J. Lipid Res. | pmid:9741690 |
| Bentinger M et al. | Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase. | 1998 | Arch. Biochem. Biophys. | pmid:9606952 |
| Nishio E et al. | Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. | 1998 | Eur. J. Pharmacol. | pmid:9650858 |
| Szilvassy Z et al. | Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits. | 1998 | Eur. J. Pharmacol. | pmid:9721042 |
| Machida K et al. | Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae. | 1998 | J. Bacteriol. | pmid:9721283 |
| Strickland CL et al. | Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. | 1998 | Biochemistry | pmid:9843427 |
| Rajab MS et al. | Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study. | 1998 | Planta Med. | pmid:9491760 |
| Llorente-Cortés V et al. | Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9598832 |
| Pérez-Sala D et al. | Analogs of farnesylcysteine induce apoptosis in HL-60 cells. | 1998 | FEBS Lett. | pmid:9600259 |
| Rubins JB et al. | Lovastatin induces apoptosis in malignant mesothelioma cells. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603146 |
| Crick DC et al. | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. | 1998 | J. Neurochem. | pmid:9603204 |
| Pei ZM et al. | Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. | 1998 | Science | pmid:9765153 |
| Egozi Y et al. | Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist. | 1999 | Int. J. Cancer | pmid:10074926 |