2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Authors Title Published Journal PubMed Link
Rotblat B et al. The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. 2008 Meth. Enzymol. pmid:18374183
Berzat AC et al. Using inhibitors of prenylation to block localization and transforming activity. 2006 Meth. Enzymol. pmid:16757354
Epand RM et al. Lipid-mediated a-factor interactions with artificial membranes. 1995 Meth. Enzymol. pmid:7651149
Wang C et al. Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. 2013 Metab. Eng. pmid:23608473
Kim SY et al. Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism. 2001 Metab. Clin. Exp. pmid:11699057
Tashiro M et al. Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis. 2012 Med. Mycol. pmid:21954955
Cordeiro RA et al. Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol. 2013 Med. Mycol. pmid:22712455
Sarazin A et al. In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line. 2010 Med. Mycol. pmid:20438293
Ershova LS et al. [Action of an analog of insect juvenile hormone farnesol ester on the flea Xenopsylla conformis Wagn]. 1988 May-Jun Med Parazitol (Mosk) pmid:3173246
Leonhardt I et al. The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. 2015 MBio pmid:25784697
Duncan RE and Archer MC Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. 2008 Lipids pmid:18509688
Hohl RJ et al. Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids. 1998 Lipids pmid:9470172
Ownby SE and Hohl RJ Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. 2002 Lipids pmid:11908910
Ownby SE and Hohl RJ Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. 2003 Lipids pmid:14506838
Kothapalli R et al. Farnesylamine: an inhibitor of farnesylation and growth of ras-transformed cells. 1993 Lipids pmid:8277827
NÄ•mec V et al. Natural and synthetic materials with insect hormone activity. 7. Juvenile activity of the farnesane-type compounds on Locusta migratoria L and Schistocerca gregaria (Forsk). 1970 Life Sci. II pmid:5478093
Satoh T et al. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. 1996 Life Sci. pmid:8831797
Chaudhary SC et al. Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. 2009 Life Sci. pmid:19470390
Pratt GE and Tobe SS Juvenile hormones radiobiosynthesised by corpora allata of adult female locusts in vitro. 1974 Life Sci. pmid:4823991
Jarolím V et al. Natural and synthetic materials with insect hormones activity. 8. Juvenile activity of the farnesane-type compounds on Galleria mellonella. 1969 Life Sci. pmid:5803377
Henriques M et al. Effect of farnesol on Candida dubliniensis morphogenesis. 2007 Lett. Appl. Microbiol. pmid:17257261
Fong C et al. Monodisperse nonionic isoprenoid-type hexahydrofarnesyl ethylene oxide surfactants: high throughput lyotropic liquid crystalline phase determination. 2011 Langmuir pmid:21294552
Khwaja A et al. The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid. 2005 Kidney Int. pmid:16014024
Lazzerini PE et al. Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. 2013 Joint Bone Spine pmid:22999910
Hasmim M et al. Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways. 2007 J. Thromb. Haemost. pmid:17059425
Yue W et al. Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. 2007 Aug-Sep J. Steroid Biochem. Mol. Biol. pmid:17616457
Huelin FE and Coggiola IM Superficial scald, a functional disorder of stored apples. IV. Effect of variety, maturity, oiled wraps and diphenylamine on the concentration of alpha-farnesene in the fruit. 1968 J. Sci. Food Agric. pmid:5659583
Wiseman DA et al. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. 2007 J. Pharmacol. Exp. Ther. pmid:17138864
Fioravanti CF and MacInnis AJ The in vitro effects of farnesol and derivatives on Hymenolepis diminuta. 1976 J. Parasitol. pmid:978365
Kubista B et al. Anticancer effects of zoledronic acid against human osteosarcoma cells. 2006 J. Orthop. Res. pmid:16602111
Rosales A et al. Synthesis of (±)-aureol by bioinspired rearrangements. 2015 J. Org. Chem. pmid:25591135
Tsangarakis C et al. Zeolite NaY-promoted cyclization of farnesal: a short route to nanaimoal. 2008 J. Org. Chem. pmid:18321121
Xie H et al. Synthesis and biological evaluation of the geometric farnesylated analogues of the a-factor mating peptide of Saccharomyces cerevisiae. 2000 J. Org. Chem. pmid:11112575
Du Y and Wiemer DF Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis. 2002 J. Org. Chem. pmid:12153272
Marciano D et al. Neuroprotective effects of the Ras inhibitor S-trans-trans-farnesylthiosalicylic acid, measured by diffusion-weighted imaging after traumatic brain injury in rats. 2007 J. Neurotrauma pmid:17711399
Bringmann A et al. Farnesol modulates membrane currents in human retinal glial cells. 2000 J. Neurosci. Res. pmid:11054809
Ronderos DS et al. Farnesol-detecting olfactory neurons in Drosophila. 2014 J. Neurosci. pmid:24623773
Kato N et al. Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. 2002 J. Neurol. Sci. pmid:12220695
Kafri M et al. Inhibition of Ras attenuates the course of experimental autoimmune neuritis. 2005 J. Neuroimmunol. pmid:16154640
Aizman E et al. The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice. 2010 J. Neuroimmunol. pmid:20869125
Karussis D et al. The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis. 2001 J. Neuroimmunol. pmid:11694313
Crick DC et al. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. 1998 J. Neurochem. pmid:9603204
Chin PC et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. 2004 J. Neurochem. pmid:15255937
Wang X et al. Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans. 2012 J. Nat. Prod. pmid:22400916
Villegas LF et al. (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids. 2001 J. Nat. Prod. pmid:11678668
Jones TH et al. Farnesylamine from the ant Monomorium fieldi Forel. 2003 J. Nat. Prod. pmid:12662086
Goodwin TE et al. African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol. 2002 J. Nat. Prod. pmid:12350155
Goodwin TE et al. African elephant sesquiterpenes. 1999 J. Nat. Prod. pmid:10579877
Li X et al. New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. 2003 J. Nat. Prod. pmid:14640527
Jansen B et al. Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice. 1999 J. Mol. Med. pmid:10619439