2E,6E-farnesol

2e,6e-farnesol is a lipid of Prenol Lipids (PR) class. 2e,6e-farnesol is associated with abnormalities such as Granulomatous Disease, Chronic, pathologic fistula and Cavitation. The involved functions are known as Regulation, Metabolic Inhibition, cholesterol biosynthetic process, Process and Transcription, Genetic. 2e,6e-farnesol often locates in Plasma membrane, Cytoplasmic matrix, cornified envelope, Epidermis and peroxisome. The associated genes with 2E,6E-farnesol are RAB3A gene, FOSL1 gene, CASP8AP2 gene, RCC1 gene and GALE gene. The related lipids are Sterols, Membrane Lipids and Steroids.

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Introduction

To understand associated biological information of 2E,6E-farnesol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2E,6E-farnesol?

2E,6E-farnesol is suspected in Granulomatous Disease, Chronic, pathologic fistula and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2E,6E-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with 2E,6E-farnesol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2E,6E-farnesol?

Related references are published most in these journals:

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What functions are associated with 2E,6E-farnesol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2E,6E-farnesol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2E,6E-farnesol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2E,6E-farnesol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2E,6E-farnesol

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Authors Title Published Journal PubMed Link
Ruiz-Velasco N et al. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. 2004 Biochem. Pharmacol. pmid:14698043
Downie MM et al. Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. 2004 Br. J. Dermatol. pmid:15491415
Inoue Y et al. The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. 2004 FEMS Microbiol. Lett. pmid:15321680
Murataliev MB et al. Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7. 2004 Biochemistry pmid:14967018
McPherson RA et al. The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. 2004 Prostate pmid:14968433
Hornby JM et al. Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. 2004 Appl. Environ. Microbiol. pmid:15006753
Wozniak M et al. Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle. 2004 Insect Biochem. Mol. Biol. pmid:15522611
Rudi A et al. Likonides A and B: new ansa farnesyl quinols from the marine sponge Hyatella sp. 2004 Org. Lett. pmid:15496087
Staines AG et al. Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1. 2004 Biochem. J. pmid:15320866
Kruppa M et al. The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. 2004 Eukaryotic Cell pmid:15302838
Fukuda S and Pelus LM Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. 2004 Biochem. Biophys. Res. Commun. pmid:15369798
Chin PC et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. 2004 J. Neurochem. pmid:15255937
Dumitru R et al. Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs. 2004 Antimicrob. Agents Chemother. pmid:15215080
Rodrigues Goulart H et al. Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum. 2004 Antimicrob. Agents Chemother. pmid:15215101
Schnuch A et al. Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. 2004 Contact Derm. pmid:15153123
Hornby JM and Nickerson KW Enhanced production of farnesol by Candida albicans treated with four azoles. 2004 Antimicrob. Agents Chemother. pmid:15155241
DeBarber AE et al. Omega-hydroxylation of farnesol by mammalian cytochromes p450. 2004 Biochim. Biophys. Acta pmid:15158752
Hartman HL et al. Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. 2004 J. Biol. Chem. pmid:15131129
Sato T et al. Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. 2004 Biol. Pharm. Bull. pmid:15133261
Thorpe JL et al. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. 2004 Dev. Cell pmid:14960282
George J et al. Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14670932
Wang Z et al. Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. 2003 Jan-Apr J Pharm Pharm Sci pmid:12753732
Sakata T et al. Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae). 2003 Exp. Appl. Acarol. pmid:14635814
Granshaw T et al. Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. 2003 J. Biol. Rhythms pmid:12932081
Koo H et al. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. 2003 J. Antimicrob. Chemother. pmid:14563892
Tóth M et al. Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. 2003 Pest Manag. Sci. pmid:12701702
Sen SE et al. Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. 2003 Insect Biochem. Mol. Biol. pmid:12770578
Katzav A et al. Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome. 2003 Immunobiology pmid:12638903
Berstein LM et al. New approaches to the understanding of tamoxifen action and resistance. 2003 Endocr. Relat. Cancer pmid:12790788
Shohami E et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. 2003 J. Cereb. Blood Flow Metab. pmid:12796721
Hornby JM et al. Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. 2003 Antimicrob. Agents Chemother. pmid:12821501
Xu L and Simoni RD The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. 2003 Arch. Biochem. Biophys. pmid:12781775
Dietrich A et al. Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. 2003 Biochem. J. pmid:12952523
Shchepin R et al. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. 2003 Chem. Biol. pmid:12954333
Giricz Z et al. Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. 2003 Basic Res. Cardiol. pmid:12955403
Iguchi T et al. Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. 2003 Cell. Signal. pmid:12742232
Clarke HC et al. Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. 2003 J. Am. Soc. Nephrol. pmid:12660318
Jones TH et al. Farnesylamine from the ant Monomorium fieldi Forel. 2003 J. Nat. Prod. pmid:12662086
Smalley KS and Eisen TG Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. 2003 Int. J. Cancer pmid:12673674
Song L Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants. 2003 Anal. Biochem. pmid:12758256
Hiyoshi H et al. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. 2003 J. Lipid Res. pmid:12518031
Töyräs A et al. Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. 2003 Eur J Pharm Sci pmid:12885386
Houten SM et al. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. 2003 Cell. Mol. Life Sci. pmid:12861380
Brehm-Stecher BF and Johnson EA Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. 2003 Antimicrob. Agents Chemother. pmid:14506058
Ownby SE and Hohl RJ Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. 2003 Lipids pmid:14506838
Mau CJ et al. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. 2003 Eur. J. Biochem. pmid:14511375
Li X et al. New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. 2003 J. Nat. Prod. pmid:14640527
McAnally JA et al. Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. 2003 Cancer Lett. pmid:14643448
Sever N et al. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. 2003 J. Biol. Chem. pmid:14563840
Grossman R et al. Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. 2003 Neuroimage pmid:14683703