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Biochemistry |
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The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. |
2004 |
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Eukaryotic Cell |
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The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. |
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2004 |
Antimicrob. Agents Chemother. |
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2004 |
Biochim. Biophys. Acta |
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Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. |
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Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. |
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Dev. Cell |
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Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae). |
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Exp. Appl. Acarol. |
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Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. |
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J. Biol. Rhythms |
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Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. |
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Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. |
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Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome. |
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Immunobiology |
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New approaches to the understanding of tamoxifen action and resistance. |
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Endocr. Relat. Cancer |
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The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. |
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J. Cereb. Blood Flow Metab. |
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Antimicrob. Agents Chemother. |
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The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. |
2003 |
Arch. Biochem. Biophys. |
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Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. |
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2003 |
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Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. |
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J. Am. Soc. Nephrol. |
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Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. |
2003 |
Int. J. Cancer |
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Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants. |
2003 |
Anal. Biochem. |
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Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. |
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J. Lipid Res. |
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Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. |
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Eur J Pharm Sci |
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Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. |
2003 |
Cell. Mol. Life Sci. |
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Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. |
2003 |
Antimicrob. Agents Chemother. |
pmid:14506058
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Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. |
2003 |
Lipids |
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Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. |
2003 |
Eur. J. Biochem. |
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2003 |
J. Nat. Prod. |
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Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. |
2003 |
Cancer Lett. |
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Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. |
2003 |
Neuroimage |
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