Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Protozoan Infections D011528 6 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Takahashi S et al. Metabolic engineering of sesquiterpene metabolism in yeast. 2007 Biotechnol. Bioeng. pmid:17013941
Green S et al. Unusual features of a recombinant apple alpha-farnesene synthase. 2007 Phytochemistry pmid:17140613
Camino-López S et al. Tissue factor induction by aggregated LDL depends on LDL receptor-related protein expression (LRP1) and Rho A translocation in human vascular smooth muscle cells. 2007 Cardiovasc. Res. pmid:17141748
Saijonmaa O et al. Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17158648
Guo RT et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17535895
Ling Y et al. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. 2007 J. Biol. Chem. pmid:17724033
Miller DJ et al. Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity. 2007 Org. Biomol. Chem. pmid:17912381
Oswald M et al. Monoterpenoid biosynthesis in Saccharomyces cerevisiae. 2007 FEMS Yeast Res. pmid:17096665
Troutman JM et al. Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release. 2007 Biochemistry pmid:17877368
Troutman JM et al. Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues. 2007 Biochemistry pmid:17854205
Feld BK and Weiss GA Convenient methods for the synthesis of P1-farnesyl-P2-indicator diphosphates. 2006 Bioorg. Med. Chem. Lett. pmid:16406516
Cane DE How to evolve a silk purse from a sow's ear. 2006 Nat. Chem. Biol. pmid:16547477
Lindahl AL et al. Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. 2006 Biotechnol. Lett. pmid:16614895
Liang SL et al. Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway. 2006 J. Immunol. pmid:16785563
Jiang J et al. Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. 2006 J. Am. Chem. Soc. pmid:16787064
Lin X et al. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. 2006 J. Am. Chem. Soc. pmid:16669656
Gutta P and Tantillo DJ Theoretical studies on farnesyl cation cyclization: pathways to pentalenene. 2006 J. Am. Chem. Soc. pmid:16669687
Sakoda K et al. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. 2006 J. Dent. Res. pmid:16723648
Kim SH et al. Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis. 2006 J. Nat. Prod. pmid:16724836
Picaud S et al. Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate. 2006 Arch. Biochem. Biophys. pmid:16143293