Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Protozoan Infections D011528 6 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Guo RT et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17535895
Frick S et al. Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23440195
Henry LK et al. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26216978
Schnee C et al. The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16418295
Kinsella BT et al. Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. 1991 Proc. Natl. Acad. Sci. U.S.A. pmid:1924354
Dolence JM and Poulter CD A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7761439
Colby SM et al. Germacrene C synthase from Lycopersicon esculentum cv. VFNT cherry tomato: cDNA isolation, characterization, and bacterial expression of the multiple product sesquiterpene cyclase. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9482865
Kovacs WJ et al. Central role of peroxisomes in isoprenoid biosynthesis. 2002 Prog. Lipid Res. pmid:12121718
Bradshaw HB et al. Orphan endogenous lipids and orphan GPCRs: a good match. 2009 Prostaglandins Other Lipid Mediat. pmid:19379823
Goyanka R et al. Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate. 2010 Protein Eng. Des. Sel. pmid:20817759