Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Osteosarcoma D012516 50 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Shishova EY et al. X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. 2008 J. Biol. Chem. pmid:18385128
Argmann CA et al. Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. 2005 J. Biol. Chem. pmid:15817453
Gonzalez-Pacanowska D et al. Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation. 1988 J. Biol. Chem. pmid:3335546
SAMUELSSON B and GOODMAN DS STEREOCHEMISTRY AT THE CENTER OF SQUALENE DURING ITS BIOSYNTHESIS FROM FARNESYL PYROPHOSPHATE AND SUBSEQUENT CONVERSION TO CHOLESTEROL. 1964 J. Biol. Chem. pmid:14114881
Guo RT et al. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. 2005 J. Biol. Chem. pmid:15788389
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Kuswik-Rabiega G and Rilling HC Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities. 1987 J. Biol. Chem. pmid:3805037
Reiss Y et al. Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme. 1992 J. Biol. Chem. pmid:1556143
Shechter I et al. Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase. 1992 J. Biol. Chem. pmid:1569107
Ericsson J et al. Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase. 1992 J. Biol. Chem. pmid:1527001
Pickett JS et al. Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand. 2003 J. Biol. Chem. pmid:14532266
Schaber MD et al. Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase. 1990 J. Biol. Chem. pmid:2203759
Reiss Y et al. Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. 1991 J. Biol. Chem. pmid:2037606
POPJAK G et al. Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis. 1962 J. Biol. Chem. pmid:14487886
Garza RM et al. Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. 2009 J. Biol. Chem. pmid:19776008
Biardi L and Krisans SK Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes. 1996 J. Biol. Chem. pmid:8576183
Otto JC and Casey PJ The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. 1996 J. Biol. Chem. pmid:8617711
Kavanagh KL et al. The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. 2006 J. Biol. Chem. pmid:16698791
Tschantz WR et al. Substrate binding is required for release of product from mammalian protein farnesyltransferase. 1997 J. Biol. Chem. pmid:9092540
Hartman HL et al. Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. 2004 J. Biol. Chem. pmid:15131129