Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Osteosarcoma D012516 50 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

Download all related citations
Per page 10 20 50 100 | Total 614
Authors Title Published Journal PubMed Link
Wiemer AJ et al. Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. 2007 Biochem. Biophys. Res. Commun. pmid:17208200
Guo RT et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17535895
Ling Y et al. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. 2007 J. Biol. Chem. pmid:17724033
Saito K et al. Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase. 2007 J. Biosci. Bioeng. pmid:17630132
Krzysiak AJ et al. Combinatorial modulation of protein prenylation. 2007 ACS Chem. Biol. pmid:17530735
Lee MH et al. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. 2007 Stem Cells pmid:17464088
Kaneko R et al. Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. 2007 J. Biol. Chem. pmid:17472962
Nakajima H et al. Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. 2007 Cancer Lett. pmid:17316980
Schmidt A and Gershenzon J Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation. 2007 Phytochemistry pmid:17624381
Kinjoh T et al. Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. 2007 Insect Biochem. Mol. Biol. pmid:17628279
Miller DJ et al. Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A. 2007 Chembiochem pmid:17683054
Das S et al. Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors. 2007 Mol. Endocrinol. pmid:17666588
Qiu G and Hill JS Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. 2007 J. Lipid Res. pmid:17644777
Shishova EY et al. X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate. 2007 Biochemistry pmid:17261032
Martínez-Sales V et al. Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. 2007 Jul-Oct Endothelium pmid:17922340
Baba TT et al. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. 2008 J. Muscle Res. Cell. Motil. pmid:18792797
Subramanian T et al. Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. 2008 Chembiochem pmid:18985644
Yu F et al. Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. 2008 FEBS Lett. pmid:18242187
Paradise EM et al. Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. 2008 Biotechnol. Bioeng. pmid:18175359
Yamashita M et al. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. 2008 J. Endocrinol. pmid:18310456