Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Osteosarcoma D012516 50 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

Download all related citations
Per page 10 20 50 100 | Total 614
Authors Title Published Journal PubMed Link
Nyati P et al. Farnesyl phosphatase, a Corpora allata enzyme involved in juvenile hormone biosynthesis in Aedes aegypti. 2013 PLoS ONE pmid:23940797
May B et al. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. 2013 Phytochemistry pmid:23954075
Du CQ et al. Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine-induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats. 2014 Hypertens. Res. pmid:23985701
Nguyen HT et al. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. 2013 Plant Physiol. Biochem. pmid:24036394
Renò F et al. Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor. 2013 Eur. J. Pharmacol. pmid:24063859
Yang CQ et al. Isolation and characterization of terpene synthases in cotton (Gossypium hirsutum). 2013 Phytochemistry pmid:24074555
van der Kamp MW et al. Conformational change and ligand binding in the aristolochene synthase catalytic cycle. 2013 Biochemistry pmid:24106830
Rashidian M et al. Simultaneous dual protein labeling using a triorthogonal reagent. 2013 J. Am. Chem. Soc. pmid:24134212
Dahl RH et al. Engineering dynamic pathway regulation using stress-response promoters. 2013 Nat. Biotechnol. pmid:24142050
Li ZH et al. Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin. 2013 PLoS Pathog. pmid:24146616
Kawasaki Y et al. Thermodynamic evaluation of the binding of bisphosphonates to human farnesyl pyrophosphate synthase. 2014 Chem. Pharm. Bull. pmid:24172032
Marcos IS et al. Sesquiterpenyl indoles. 2013 Nat Prod Rep pmid:24172769
Huang X et al. Identification and characterization of (E)-β-caryophyllene synthase and α/β-pinene synthase potentially involved in constitutive and herbivore-induced terpene formation in cotton. 2013 Plant Physiol. Biochem. pmid:24184450
Yang C et al. Simvastatin-enhanced expression of promyogenic nuclear factors and cardiomyogenesis of murine embryonic stem cells. 2014 Vascul. Pharmacol. pmid:24200505
Burgazli KM et al. The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs). 2013 Eur Rev Med Pharmacol Sci pmid:24254555
Nowroozi FF et al. Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly. 2014 Appl. Microbiol. Biotechnol. pmid:24257840
Chen X et al. Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. 2013 PLoS ONE pmid:24278153
Wang H et al. Studies on the expression of sesquiterpene synthases using promoter-β-glucuronidase fusions in transgenic Artemisia annua L. 2013 PLoS ONE pmid:24278301
Wood WG et al. Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. 2014 J. Neurochem. pmid:24329875
Mabanglo MF et al. Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. 2014 Protein Sci. pmid:24347326
Smith R et al. Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. 2014 PLoS ONE pmid:24416446
pmid:24430210
Liu CI et al. Structural insights into the catalytic mechanism of human squalene synthase. 2014 Acta Crystallogr. D Biol. Crystallogr. pmid:24531458
Hartwig S et al. Expression, purification and activity assay of a patchoulol synthase cDNA variant fused to thioredoxin in Escherichia coli. 2014 Protein Expr. Purif. pmid:24576659
pmid:24692239
Yokoyama T et al. Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate. 2014 Acta Crystallogr F Struct Biol Commun pmid:24699741
pmid:24762323
Shang N et al. Squalene synthase as a target for Chagas disease therapeutics. 2014 PLoS Pathog. pmid:24789335
Alcaíno J et al. Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors. 2014 PLoS ONE pmid:24796858
pmid:24809278
Han X et al. Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. 2015 Proteins pmid:24895191
pmid:24910970
Dozier JK et al. Engineering protein farnesyltransferase for enzymatic protein labeling applications. 2014 Bioconjug. Chem. pmid:24946229
pmid:24996285
pmid:25027024
pmid:25056927
pmid:25159317
Gonzalez V et al. Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase. 2014 J. Am. Chem. Soc. pmid:25230152
Danley DE et al. Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase. 2015 Protein Sci. pmid:25287857
Yoshida I et al. Protection of hexaprenyl-diphosphate synthase of Micrococcus luteus B-P 26 against inactivation by sulphydryl reagents and arginine-specific reagents. 1989 Biochim. Biophys. Acta pmid:2539196
Yoshida I et al. Formation of a stable and catalytically active complex of the two essential components of hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26. 1989 Biochem. Biophys. Res. Commun. pmid:2541701
Hohn TM and Plattner RD Purification and characterization of the sesquiterpene cyclase aristolochene synthase from Penicillium roqueforti. 1989 Arch. Biochem. Biophys. pmid:2544140
pmid:25472483
pmid:25475893
pmid:25631750
pmid:25658388
pmid:25680349
pmid:25698327
pmid:25701786
pmid:25734506
pmid:25739905
pmid:25807032
pmid:25822613
Sharon C et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. 2015 Oncotarget pmid:25895029
Rising KA et al. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. 2015 ACS Chem. Biol. pmid:25897591
pmid:25940560
Srivastava PL et al. Functional Characterization of Novel Sesquiterpene Synthases from Indian Sandalwood, Santalum album. 2015 Sci Rep pmid:25976282
Ferriols VM et al. Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera. 2015 Sci Rep pmid:25996801
pmid:26051402
ElAzzouny MA et al. Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells. 2015 PLoS ONE pmid:26107620
Henry LK et al. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26216978
pmid:26361082
pmid:26556845
Nyati P et al. Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes. 2015 PLoS ONE pmid:26566274
Harris GG et al. Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. 2015 Biochemistry pmid:26598179
pmid:26610064
pmid:26626450
Pant A and Kocarek TA Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes. 2016 Drug Metab. Dispos. pmid:26700959
pmid:26756303
pmid:26757191
pmid:26758949
Fujisaki S et al. Isolation and characterization of an Escherichia coli mutant having temperature-sensitive farnesyl diphosphate synthase. 1989 J. Bacteriol. pmid:2676985
pmid:26781029
Jennings BC et al. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. 2016 Bioorg. Med. Chem. Lett. pmid:26803203
pmid:26873186
pmid:26908642
Pastar I et al. Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration. 2016 J. Cell. Physiol. pmid:26916741
pmid:26920719
Matsumoto Y et al. A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. 2016 Sci Rep pmid:26961421
Grundy DJ et al. Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture. 2016 Biochemistry pmid:26998816
pmid:27005818
pmid:27042994
pmid:27231873
Terabe K et al. Simvastatin inhibits CD44 fragmentation in chondrocytes. 2016 Arch. Biochem. Biophys. pmid:27242325
pmid:27273626
Croteau R and Purkett PT Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis). 1989 Arch. Biochem. Biophys. pmid:2730002
Yang J et al. Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats. 2016 Cell. Physiol. Biochem. pmid:27336844
pmid:27428767
pmid:27440491
pmid:27471067
pmid:27560952
pmid:27561253
Wong MJ et al. Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27694473
pmid:27933789
pmid:27939849
pmid:28057800
Light DR and Dennis MS Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis. 1989 J. Biol. Chem. pmid:2808388
Light DR et al. Rubber elongation by farnesyl pyrophosphate synthases involves a novel switch in enzyme stereospecificity. 1989 J. Biol. Chem. pmid:2808389
Qian J et al. Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants. 2017 BMC Mol. Biol. pmid:28160774
Kosek V et al. High resolution mass spectrometry based method applicable for a wide range of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors in blood serum including intermediates and products of the cholesterol biosynthetic pathway. 2017 J Chromatogr A pmid:28209347