Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Osteosarcoma D012516 50 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Danesi R et al. Specific labeling of isoprenylated proteins: application to study inhibitors of the post-translational farnesylation and geranylgeranylation. 1995 Biochem. Biophys. Res. Commun. pmid:7826382
Christensen DJ and Poulter CD Enzymatic synthesis of isotopically labeled isoprenoid diphosphates. 1994 Bioorg. Med. Chem. pmid:7858969
Soltis DA et al. Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems. 1995 Arch. Biochem. Biophys. pmid:7864626
Zhao J et al. Farnesylation of p21 Ras proteins in Xenopus oocytes. 1994 Cell. Mol. Biol. Res. pmid:7866432
Cane DE et al. Trichodiene synthase. Substrate specificity and inhibition. 1995 Biochemistry pmid:7873526
Cane DE et al. Trichodiene synthase. Identification of active site residues by site-directed mutagenesis. 1995 Biochemistry pmid:7873527
Bansal VS and Vaidya S Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes. 1994 Arch. Biochem. Biophys. pmid:7986083
Correll CC et al. Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1994 J. Biol. Chem. pmid:8021239
Sagami H et al. Novel isoprenoid modified proteins in Halobacteria. 1994 Biochem. Biophys. Res. Commun. pmid:8093082
Bradfute DL and Simoni RD Non-sterol compounds that regulate cholesterogenesis. Analogues of farnesyl pyrophosphate reduce 3-hydroxy-3-methylglutaryl-coenzyme A reductase levels. 1994 J. Biol. Chem. pmid:8120018