Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Protozoan Infections D011528 6 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Fujikura K et al. Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs. 2008 Biosci. Biotechnol. Biochem. pmid:18323637
Liu CI et al. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. 2008 Science pmid:18276850
Ogunwobi OO and Beales IL Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. 2008 Am. J. Gastroenterol. pmid:18371146
Shishova EY et al. X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. 2008 J. Biol. Chem. pmid:18385128
Srivastava A et al. Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. 2008 Infect Disord Drug Targets pmid:18473904
Tsubaki M et al. Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells. 2008 Cancer Sci. pmid:17979996
Jiang J and Cane DE Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin. 2008 J. Am. Chem. Soc. pmid:18095692
Davidovich-Rikanati R et al. Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit. 2008 Plant J. pmid:18643974
Baba TT et al. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. 2008 J. Muscle Res. Cell. Motil. pmid:18792797
Subramanian T et al. Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. 2008 Chembiochem pmid:18985644
Giglio S et al. Isolation and characterization of the gene associated with geosmin production in cyanobacteria. 2008 Environ. Sci. Technol. pmid:19031897
Oh DY et al. Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. 2008 J. Biol. Chem. pmid:18499677
Gao L et al. Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. 2008 J. Pharmacol. Exp. Ther. pmid:18441251
Paradise EM et al. Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. 2008 Biotechnol. Bioeng. pmid:18175359
Yamashita M et al. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. 2008 J. Endocrinol. pmid:18310456
Peukert S et al. Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. 2008 Bioorg. Med. Chem. Lett. pmid:18295483
Farquharson KL A sesquiterpene distress signal transmitted by maize. 2008 Plant Cell pmid:18296624
Köllner TG et al. A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties. 2008 Plant Cell pmid:18296628
Fu Z et al. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. 2008 Biochemistry pmid:18302342
Martínez-Sales V et al. Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. 2007 Jul-Oct Endothelium pmid:17922340