Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Protozoan Infections D011528 6 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Thelin A et al. Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. 1994 Biochim. Biophys. Acta pmid:7811707
Liliom K et al. Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs. 2006 Biochim. Biophys. Acta pmid:17092771
Raisig A and Sandmann G Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways. 2001 Biochim. Biophys. Acta pmid:11566453
Koyama T et al. Substrate specificity of squalene synthetase. 1980 Biochim. Biophys. Acta pmid:7357018
Sagami H et al. The biosynthesis of dehydrodolichyl phosphates by rat liver microsomes. 1989 Biochim. Biophys. Acta pmid:2930770
Newman P et al. Polyisoprenylation of the CAAX motif--an in vitro protein synthesis study. 1991 Biochim. Biophys. Acta pmid:1954230
Yoshida I et al. Protection of hexaprenyl-diphosphate synthase of Micrococcus luteus B-P 26 against inactivation by sulphydryl reagents and arginine-specific reagents. 1989 Biochim. Biophys. Acta pmid:2539196
Pan JJ et al. Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis. 2002 Biochim. Biophys. Acta pmid:11825609
Ericsson J et al. Biosynthesis of dolichol and cholesterol in rat liver peroxisomes. 1993 Biochimie pmid:8507678
Troutman JM et al. Tools to analyze protein farnesylation in cells. 2005 Sep-Oct Bioconjug. Chem. pmid:16173800
Dozier JK et al. Engineering protein farnesyltransferase for enzymatic protein labeling applications. 2014 Bioconjug. Chem. pmid:24946229
Sinensky M and Lutz RJ The prenylation of proteins. 1992 Bioessays pmid:1546978
Sokalska A et al. Simvastatin decreases invasiveness of human endometrial stromal cells. 2012 Biol. Reprod. pmid:22492974
Rzepczynska IJ et al. Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. 2009 Biol. Reprod. pmid:19571257
Goalstone ML et al. Characterization of Xenopus laevis oocyte farnesyl transferase. 1996 Biol. Reprod. pmid:8835391
Ortega I et al. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. 2012 Biol. Reprod. pmid:21918126
da Costa BM et al. Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor. 2005 Jan-Feb Biomacromolecules pmid:15638531
Fairlamb IJ et al. Synthesis and antimicrobial evaluation of farnesyl diphosphate mimetics. 2003 Bioorg. Chem. pmid:12697170
Teng KH and Liang PH Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis. 2012 Bioorg. Chem. pmid:21993493
Eummer JT et al. Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors. 1999 Bioorg. Med. Chem. pmid:10218815