Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Protozoan Infections D011528 6 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

Download all related citations
Per page 10 20 50 100 | Total 614
Authors Title Published Journal PubMed Link
Rojruthai P et al. In vitro synthesis of high molecular weight rubber by Hevea small rubber particles. 2010 J. Biosci. Bioeng. pmid:20129092
Saito K et al. Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase. 2007 J. Biosci. Bioeng. pmid:17630132
Melillo E et al. Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous. 2012 J. Biotechnol. pmid:22771888
Woo JT et al. Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. 2000 J. Bone Miner. Res. pmid:10780857
Fenton RG et al. Regulation of intracellular actin polymerization by prenylated cellular proteins. 1992 J. Cell Biol. pmid:1560030
Kizu A et al. Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. 2004 J. Cell. Biochem. pmid:15389884
Kato S et al. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. 2010 J. Cell. Mol. Med. pmid:19432822
Pastar I et al. Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration. 2016 J. Cell. Physiol. pmid:26916741
Pahan K et al. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. 1997 J. Clin. Invest. pmid:9389730
Rowinsky EK et al. Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development. 1999 J. Clin. Oncol. pmid:10550163
Sakoda K et al. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. 2006 J. Dent. Res. pmid:16723648
Yamashita M et al. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. 2008 J. Endocrinol. pmid:18310456
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Chen CH et al. Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR. 2002 J. Exp. Zool. pmid:12410604
Chen HC et al. Differential effects of prenyl pyrophosphates on the phosphatase activity of phosphotyrosyl protein phosphatase. 2004 J. Exp. Zoolog. Part A Comp. Exp. Biol. pmid:15039989
Chen YH et al. Effects of prenyl pyrophosphates on the binding of PKCgamma with RACK1. 2003 J. Exp. Zoolog. Part A Comp. Exp. Biol. pmid:12506405
Huang CF et al. Farnesyl pyrophosphate promotes and is essential for the binding of RACK1 with beta-tubulin. 2003 J. Exp. Zoolog. Part A Comp. Exp. Biol. pmid:12884273
Liang SL et al. Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway. 2006 J. Immunol. pmid:16785563
Sadeghi MM et al. Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. 2000 J. Immunol. pmid:10946302
Matsumoto M et al. Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. 2004 J. Immunol. pmid:15187114