| Cusson M et al. |
Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones. |
2006 |
Proteins |
pmid:16972283
|
| Pozo M et al. |
Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. |
2006 |
Eur. J. Pharmacol. |
pmid:16973154
|
| Takahashi S et al. |
Metabolic engineering of sesquiterpene metabolism in yeast. |
2007 |
Biotechnol. Bioeng. |
pmid:17013941
|
| Cane DE et al. |
Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. |
2006 |
J. Antibiot. |
pmid:17080683
|
| Liliom K et al. |
Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs. |
2006 |
Biochim. Biophys. Acta |
pmid:17092771
|
| Oswald M et al. |
Monoterpenoid biosynthesis in Saccharomyces cerevisiae. |
2007 |
FEMS Yeast Res. |
pmid:17096665
|
| Suzuki T et al. |
Direct observation of substrate-enzyme complexation by surface forces measurement. |
2006 |
J. Am. Chem. Soc. |
pmid:17117872
|
| Green S et al. |
Unusual features of a recombinant apple alpha-farnesene synthase. |
2007 |
Phytochemistry |
pmid:17140613
|
| Camino-López S et al. |
Tissue factor induction by aggregated LDL depends on LDL receptor-related protein expression (LRP1) and Rho A translocation in human vascular smooth muscle cells. |
2007 |
Cardiovasc. Res. |
pmid:17141748
|
| Saijonmaa O et al. |
Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. |
2007 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:17158648
|
| Kloer DP et al. |
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba. |
2006 |
Biochemistry |
pmid:17176041
|
| Roberts MJ et al. |
Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors. |
2006 |
Biochemistry |
pmid:17176109
|
| Goeke A et al. |
A novel approach to prezizaane sesquiterpenes. |
2004 |
Chem. Biodivers. |
pmid:17191831
|
| Wiemer AJ et al. |
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. |
2007 |
Biochem. Biophys. Res. Commun. |
pmid:17208200
|
| Shishova EY et al. |
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate. |
2007 |
Biochemistry |
pmid:17261032
|
| Nguyen UT et al. |
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. |
2007 |
Chembiochem |
pmid:17279592
|
| Nakajima H et al. |
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. |
2007 |
Cancer Lett. |
pmid:17316980
|
| Sealey-Cardona M et al. |
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives. |
2007 |
Antimicrob. Agents Chemother. |
pmid:17371809
|
| Lee MH et al. |
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. |
2007 |
Stem Cells |
pmid:17464088
|
| Kaneko R et al. |
Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. |
2007 |
J. Biol. Chem. |
pmid:17472962
|
| Krzysiak AJ et al. |
Combinatorial modulation of protein prenylation. |
2007 |
ACS Chem. Biol. |
pmid:17530735
|
| Guo RT et al. |
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17535895
|
| Das NP and Allen CM |
Inhibition of farnesyl transferases from malignant and non-malignant cultured human lymphocytes by prenyl substrate analogues. |
1991 |
Biochem. Biophys. Res. Commun. |
pmid:1755854
|
| Schmidt A and Gershenzon J |
Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation. |
2007 |
Phytochemistry |
pmid:17624381
|
| Kinjoh T et al. |
Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. |
2007 |
Insect Biochem. Mol. Biol. |
pmid:17628279
|
| Saito K et al. |
Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase. |
2007 |
J. Biosci. Bioeng. |
pmid:17630132
|
| Qiu G and Hill JS |
Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. |
2007 |
J. Lipid Res. |
pmid:17644777
|
| Ericsson J et al. |
Characterization and distribution of cis-prenyl transferase participating in liver microsomal polyisoprenoid biosynthesis. |
1991 |
Eur. J. Biochem. |
pmid:1765092
|
| Das S et al. |
Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors. |
2007 |
Mol. Endocrinol. |
pmid:17666588
|
| Miller DJ et al. |
Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A. |
2007 |
Chembiochem |
pmid:17683054
|
| Ling Y et al. |
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. |
2007 |
J. Biol. Chem. |
pmid:17724033
|
| Matsumura Y et al. |
The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. |
2007 |
J. Biochem. |
pmid:17846065
|
| Troutman JM et al. |
Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues. |
2007 |
Biochemistry |
pmid:17854205
|
| Troutman JM et al. |
Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release. |
2007 |
Biochemistry |
pmid:17877368
|
| Faraldos JA et al. |
Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. |
2007 |
Chembiochem |
pmid:17886322
|
| Miller DJ et al. |
Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity. |
2007 |
Org. Biomol. Chem. |
pmid:17912381
|
| Cui G and Merz KM |
Computational studies of the farnesyltransferase ternary complex part II: the conformational activation of farnesyldiphosphate. |
2007 |
Biochemistry |
pmid:17918965
|
| MartÃnez-Sales V et al. |
Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. |
2007 Jul-Oct |
Endothelium |
pmid:17922340
|
| Jantzen F et al. |
Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. |
2007 |
J. Physiol. Pharmacol. |
pmid:17928646
|
| Finlay GA et al. |
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. |
2007 |
Cancer Res. |
pmid:17942919
|
| Labadie GR et al. |
Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions. |
2007 |
J. Org. Chem. |
pmid:17979291
|
| Tsubaki M et al. |
Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells. |
2008 |
Cancer Sci. |
pmid:17979996
|
| Liang YJ et al. |
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. |
2008 |
Cardiology |
pmid:18057884
|
| Jiang J and Cane DE |
Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin. |
2008 |
J. Am. Chem. Soc. |
pmid:18095692
|
| Paradise EM et al. |
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. |
2008 |
Biotechnol. Bioeng. |
pmid:18175359
|
| Rawat DS et al. |
Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues. |
2008 |
J. Org. Chem. |
pmid:18225915
|
| Yu F et al. |
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. |
2008 |
FEBS Lett. |
pmid:18242187
|
| Liu CI et al. |
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. |
2008 |
Science |
pmid:18276850
|
| Peukert S et al. |
Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18295483
|
| Farquharson KL |
A sesquiterpene distress signal transmitted by maize. |
2008 |
Plant Cell |
pmid:18296624
|
| Köllner TG et al. |
A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties. |
2008 |
Plant Cell |
pmid:18296628
|
| Fu Z et al. |
Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. |
2008 |
Biochemistry |
pmid:18302342
|
| Yamashita M et al. |
Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. |
2008 |
J. Endocrinol. |
pmid:18310456
|
| Fujikura K et al. |
Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs. |
2008 |
Biosci. Biotechnol. Biochem. |
pmid:18323637
|
| Saito A et al. |
Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
2008 |
Melanoma Res. |
pmid:18337644
|
| Ogunwobi OO and Beales IL |
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. |
2008 |
Am. J. Gastroenterol. |
pmid:18371146
|
| Shishova EY et al. |
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. |
2008 |
J. Biol. Chem. |
pmid:18385128
|
| Gao L et al. |
Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18441251
|
| Tong H et al. |
Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. |
2008 |
Anal. Biochem. |
pmid:18457649
|
| Srivastava A et al. |
Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. |
2008 |
Infect Disord Drug Targets |
pmid:18473904
|
| Oh DY et al. |
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. |
2008 |
J. Biol. Chem. |
pmid:18499677
|
| Tenta R et al. |
Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells. |
2008 |
Horm. Metab. Res. |
pmid:18563678
|
| Sundararaj KP et al. |
Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation. |
2008 |
J. Leukoc. Biol. |
pmid:18625914
|
| Davidovich-Rikanati R et al. |
Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit. |
2008 |
Plant J. |
pmid:18643974
|
| Wada H et al. |
Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18671946
|
| Lodewyk MW et al. |
Computational studies on biosynthetic carbocation rearrangements leading to sativene, cyclosativene, alpha-ylangene, and beta-ylangene. |
2008 |
J. Org. Chem. |
pmid:18681400
|
| Liu H et al. |
Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. |
2009 |
Cancer Chemother. Pharmacol. |
pmid:18766339
|
| Baba TT et al. |
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
pmid:18792797
|
| Xie W et al. |
Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species. |
2008 |
Phytochemistry |
pmid:18799172
|
| Subramanian T et al. |
Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. |
2008 |
Chembiochem |
pmid:18985644
|
| Nonaka M et al. |
Role for protein geranylgeranylation in adult T-cell leukemia cell survival. |
2009 |
Exp. Cell Res. |
pmid:18992741
|
| Giglio S et al. |
Isolation and characterization of the gene associated with geosmin production in cyanobacteria. |
2008 |
Environ. Sci. Technol. |
pmid:19031897
|
| Lu YP et al. |
Different reaction mechanisms for cis- and trans-prenyltransferases. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19103164
|
| Sallaud C et al. |
A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. |
2009 |
Plant Cell |
pmid:19155349
|
| Cao L et al. |
An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19168029
|
| Miller DJ et al. |
6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase. |
2009 |
Org. Biomol. Chem. |
pmid:19225680
|
| Kinsella BT et al. |
Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid. |
1991 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1924354
|
| Uchida H et al. |
Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L. |
2009 |
Planta |
pmid:19283408
|
| Kim SE et al. |
Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. |
2009 |
Exp. Mol. Med. |
pmid:19299917
|
| Seong KY et al. |
Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. |
2009 |
Mol. Microbiol. |
pmid:19320833
|
| Maeda S et al. |
Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. |
2009 |
J. Pharmacol. Sci. |
pmid:19352075
|
| Bradshaw HB et al. |
Orphan endogenous lipids and orphan GPCRs: a good match. |
2009 |
Prostaglandins Other Lipid Mediat. |
pmid:19379823
|
| Sillero MA et al. |
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. |
2009 |
Biochem. Pharmacol. |
pmid:19414000
|
| Rothwell C et al. |
Cholesterol biosynthesis modulation regulates dengue viral replication. |
2009 |
Virology |
pmid:19419745
|
| Kato S et al. |
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. |
2010 |
J. Cell. Mol. Med. |
pmid:19432822
|
| Henry O et al. |
A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes. |
2009 |
Bioorg. Med. Chem. |
pmid:19447628
|
| Eckert GP et al. |
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. |
2009 |
Neurobiol. Dis. |
pmid:19464372
|
| Wang CM et al. |
Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol. |
2009 |
J. Am. Chem. Soc. |
pmid:19476353
|
| Newman P et al. |
Polyisoprenylation of the CAAX motif--an in vitro protein synthesis study. |
1991 |
Biochim. Biophys. Acta |
pmid:1954230
|
| Coudray L et al. |
Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase. |
2009 |
J Enzyme Inhib Med Chem |
pmid:19555171
|
| Rzepczynska IJ et al. |
Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. |
2009 |
Biol. Reprod. |
pmid:19571257
|
| Holstein SA et al. |
Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. |
2010 |
Leuk. Res. |
pmid:19646757
|
| Harada H and Misawa N |
Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli. |
2009 |
Appl. Microbiol. Biotechnol. |
pmid:19672590
|
| Lee M et al. |
P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. |
2009 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:19679818
|
| Singkaravanit S et al. |
Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi. |
2010 |
Appl. Microbiol. Biotechnol. |
pmid:19690851
|
| Vandermoten S et al. |
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase. |
2009 |
Insect Biochem. Mol. Biol. |
pmid:19720147
|
| Hong YJ and Tantillo DJ |
Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog. |
2009 |
Org. Biomol. Chem. |
pmid:19763318
|
| Garza RM et al. |
Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. |
2009 |
J. Biol. Chem. |
pmid:19776008
|
| Holstein SA et al. |
Quantitative determination of geranyl diphosphate levels in cultured human cells. |
2009 |
Lipids |
pmid:19856009
|
| Zhao B et al. |
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site. |
2009 |
J. Biol. Chem. |
pmid:19858213
|
