Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Osteosarcoma D012516 50 associated lipids
Protozoan Infections D011528 6 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Endometriosis D004715 29 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Gopalan A et al. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. 2013 Cancer Lett. pmid:22960596
Huang X et al. Identification and characterization of (E)-β-caryophyllene synthase and α/β-pinene synthase potentially involved in constitutive and herbivore-induced terpene formation in cotton. 2013 Plant Physiol. Biochem. pmid:24184450
Yang CQ et al. Isolation and characterization of terpene synthases in cotton (Gossypium hirsutum). 2013 Phytochemistry pmid:24074555
Valente AJ et al. Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. 2013 Cell. Signal. pmid:23541442
Xiao H et al. Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. 2013 PLoS ONE pmid:23555637
Burgazli KM et al. The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs). 2013 Eur Rev Med Pharmacol Sci pmid:24254555
Marcos IS et al. Sesquiterpenyl indoles. 2013 Nat Prod Rep pmid:24172769
Renò F et al. Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor. 2013 Eur. J. Pharmacol. pmid:24063859
Chen M et al. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. 2013 Biochemistry pmid:23905850
Dahl RH et al. Engineering dynamic pathway regulation using stress-response promoters. 2013 Nat. Biotechnol. pmid:24142050
van der Kamp MW et al. Conformational change and ligand binding in the aristolochene synthase catalytic cycle. 2013 Biochemistry pmid:24106830
May B et al. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. 2013 Phytochemistry pmid:23954075
Rashidian M et al. Simultaneous dual protein labeling using a triorthogonal reagent. 2013 J. Am. Chem. Soc. pmid:24134212
Wang H et al. Studies on the expression of sesquiterpene synthases using promoter-β-glucuronidase fusions in transgenic Artemisia annua L. 2013 PLoS ONE pmid:24278301
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Högberg C et al. Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y₁₂ receptor-mediated platelet aggregation. 2012 Thromb. Haemost. pmid:22628078
Scalcinati G et al. Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae. 2012 Microb. Cell Fact. pmid:22938570
Nagel R et al. Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. 2012 Anal. Biochem. pmid:22266300
Garrett SR et al. Steady-state kinetic characterization of sesquiterpene synthases by gas chromatography-mass spectroscopy. 2012 Meth. Enzymol. pmid:22999167
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Lujan DK et al. Chemoenzymatic synthesis of an isoprenoid phosphate tool for the analysis of complex bacterial oligosaccharide biosynthesis. 2012 Carbohydr. Res. pmid:22925763
Zhang YL and Li ZX Functional analysis and molecular docking identify two active short-chain prenyltransferases in the green peach aphid, Myzus persicae. 2012 Arch. Insect Biochem. Physiol. pmid:22696503
Placzek AT et al. Synthesis of frame-shifted farnesyl diphosphate analogs. 2012 Org. Lett. pmid:22857735
Moody SC et al. Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes. 2012 FEBS J. pmid:22151149
Melillo E et al. Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous. 2012 J. Biotechnol. pmid:22771888
Sokalska A et al. Simvastatin decreases invasiveness of human endometrial stromal cells. 2012 Biol. Reprod. pmid:22492974
Hooff GP et al. Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. 2012 Mol. Neurobiol. pmid:22692983
Faraldos JA et al. A 1,6-ring closure mechanism for (+)-δ-cadinene synthase? 2012 J. Am. Chem. Soc. pmid:22397618
Baadhe RR et al. Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. 2012 Appl. Biochem. Biotechnol. pmid:22350871
Kera K et al. Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana. 2012 FEBS J. pmid:22883514
Keim V et al. Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. 2012 PLoS ONE pmid:23145086
Vega-Pérez JM et al. Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: synthesis and in vitro antimicrobial and cytotoxic activities. 2012 Eur J Med Chem pmid:23174318
Bleeker PM et al. Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:23169639
Subramanian T et al. Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. 2012 Biochemistry pmid:22989235
Faraldos JA et al. Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases. 2012 J. Am. Chem. Soc. pmid:23214943
Bitok JK and Meyers CF 2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity. 2012 ACS Chem. Biol. pmid:22839733
Wilson MC and Moore BS Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. 2012 Nat Prod Rep pmid:22124767
Exnowitz F et al. NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves. 2012 Biochim. Biophys. Acta pmid:22079737
Ortega I et al. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. 2012 Biol. Reprod. pmid:21918126
Takami T et al. A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. 2012 PLoS ONE pmid:23145048
Teng KH and Liang PH Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis. 2012 Bioorg. Chem. pmid:21993493
Cornish K and Xie W Natural rubber biosynthesis in plants: rubber transferase. 2012 Meth. Enzymol. pmid:22999170
Zhang J et al. Modeling studies with Helicobacter pylori octaprenyl pyrophosphate synthase reveal the enzymatic mechanism of trans-prenyltransferases. 2012 Int. J. Biochem. Cell Biol. pmid:22982238
Teng KH and Liang PH Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. 2012 Mol. Membr. Biol. pmid:22471620
Yokota K et al. Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. 2011 Jan-Feb Clin. Exp. Rheumatol. pmid:21345291
Hu Y et al. Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases. 2011 Chem. Biol. pmid:21276937
Cazzola M et al. Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi. 2011 Am. J. Respir. Cell Mol. Biol. pmid:21278325
Bang S et al. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. 2011 Pain pmid:21353389
Von Zee CL and Stubbs EB Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells. 2011 Invest. Ophthalmol. Vis. Sci. pmid:21212187
Goto T et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. 2011 Biochem. J. pmid:21605082