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Cracking down on caveolin: role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in modulating edothelial cell nitric oxide production. |
2001 |
Circulation |
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Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways. |
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Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. |
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Leukemia |
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Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects. |
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Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. |
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Study on the biosynthesis of dolichol in yeast: recognition of the prenyl chain length in polyprenol reduction. |
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Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors. |
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Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human gamma delta T cells. |
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Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. |
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Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis. |
2000 |
Planta |
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Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction. |
2000 |
Biochemistry |
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Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. |
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Identification of natural rubber and characterization of rubber biosynthetic activity in fig tree. |
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Plant Physiol. |
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Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells. |
2000 |
Hypertension |
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Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. |
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J. Bone Miner. Res. |
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Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. |
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Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L. |
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Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. |
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Circ. Res. |
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Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II. |
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Biochemistry |
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Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. |
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Grignard-mediated synthesis and preliminary biological evaluation of novel 3-substituted farnesyl diphosphate analogues. |
2000 |
Bioorg. Med. Chem. Lett. |
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Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. |
2000 |
Biochemistry |
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Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharanthus roseus (L.) G. Don. |
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Arch. Biochem. Biophys. |
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Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue. |
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Eur. J. Cancer |
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Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state. |
2000 |
Biochemistry |
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HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. |
2000 |
Arterioscler. Thromb. Vasc. Biol. |
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The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. |
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Structure |
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Phosphorylation of geranyl and farnesyl pyrophosphates by Nm23 proteins/nucleoside diphosphate kinases. |
2000 |
J. Biol. Chem. |
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Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis. |
2000 |
J. Biol. Chem. |
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Chain length determination of prenyltransferases: both heteromeric subunits of medium-chain (E)-prenyl diphosphate synthase are involved in the product chain length determination. |
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Biochemistry |
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Synthesis and antiproliferative activity of N-acylaspartic acid dimethyl esters. |
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Anticancer Res. |
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Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. |
1999 |
Clin. Cancer Res. |
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Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis. |
1999 |
Plant Physiol. |
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Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. |
1999 |
J. Lipid Res. |
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The molecular cloning of 8-epicedrol synthase from Artemisia annua. |
1999 |
Arch. Biochem. Biophys. |
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Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L. |
1999 |
Arch. Biochem. Biophys. |
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A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. |
1999 |
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Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development. |
1999 |
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