Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
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pmid:
ANDERSON DG et al. The conversion of farnesyl pyrophosphate to squalene by soluble extracts of microsomes. 1960 Biochem. Biophys. Res. Commun. pmid:13683185
POPJAK G et al. Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. 1961 J. Biol. Chem. pmid:13737104
POPJAK G et al. Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis. 1962 J. Biol. Chem. pmid:14487886
BEELER DA et al. The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. 1963 Arch. Biochem. Biophys. pmid:13970235
SAMUELSSON B and GOODMAN DS STEREOCHEMISTRY AT THE CENTER OF SQUALENE DURING ITS BIOSYNTHESIS FROM FARNESYL PYROPHOSPHATE AND SUBSEQUENT CONVERSION TO CHOLESTEROL. 1964 J. Biol. Chem. pmid:14114881
Koyama T et al. Substrate specificity of squalene synthetase. 1980 Biochim. Biophys. Acta pmid:7357018
Saito Y and Ogura K Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions. 1981 J. Biochem. pmid:7275947
Saito A and Rilling HC The formation of cyclic sesquiterpenes from farnesyl pyrophosphate by prenyltransferase. 1981 Arch. Biochem. Biophys. pmid:7259201
Takahashi I and Ogura K Farnesyl pyrophosphate synthetase from Bacillus subtilis. 1981 J. Biochem. pmid:6792191
Ness GC et al. Influence of mevalonate kinase on studies of the MgATP-dependent inactivator of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1982 Arch. Biochem. Biophys. pmid:6284035
Baker FC et al. Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta. 1983 J. Lipid Res. pmid:6366103
Cane DE Cell-free studies of monoterpene and sesquiterpene biosynthesis. 1983 Biochem. Soc. Trans. pmid:6642060
Ishii K et al. Decaprenyl pyrophosphate synthetase from mitochondria of pig liver. 1983 Biochem. Biophys. Res. Commun. pmid:6651825
Brindle PA and Threlfall DR The metabolism of phytoalexins. 1983 Biochem. Soc. Trans. pmid:6642061
Dull BJ et al. The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinone. 1983 Atherosclerosis pmid:6661267
Croteau R and Gundy A Cyclization of farnesyl pyrophosphate to the sesquiterpene olefins humulene and caryophyllene by an enzyme system from sage (Salvia officinalis). 1984 Arch. Biochem. Biophys. pmid:6486812
Agnew WS Squalene synthetase. 1985 Meth. Enzymol. pmid:3894879
Cane DE Stereochemical studies of natural products biosynthesis. 1986 Ann. N. Y. Acad. Sci. pmid:3460491
Fujisaki S et al. Biosynthesis of isoprenoids in intact cells of Escherichia coli. 1986 J. Biochem. pmid:3519600
Kuswik-Rabiega G and Rilling HC Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities. 1987 J. Biol. Chem. pmid:3805037
Croteau R et al. Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations. 1987 Arch. Biochem. Biophys. pmid:3038029
Cane DE and Pargellis C Partial purification and characterization of pentalenene synthase. 1987 Arch. Biochem. Biophys. pmid:3579312
M'Baya B and Karst F In vitro assay of squalene epoxidase of Saccharomyces cerevisiae. 1987 Biochem. Biophys. Res. Commun. pmid:3307781
Gonzalez-Pacanowska D et al. Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation. 1988 J. Biol. Chem. pmid:3335546
Sasiak K and Rilling HC Purification to homogeneity and some properties of squalene synthetase. 1988 Arch. Biochem. Biophys. pmid:3277535
Bruenger E and Rilling HC Determination of isopentenyl diphosphate and farnesyl diphosphate in tissue samples with a comment on secondary regulation of polyisoprenoid biosynthesis. 1988 Anal. Biochem. pmid:3189812
Biller SA et al. Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase. 1988 J. Med. Chem. pmid:3172121
Dehal SS and Croteau R Partial purification and characterization of two sesquiterpene cyclases from sage (Salvia officinalis) which catalyze the respective conversion of farnesyl pyrophosphate to humulene and caryophyllene. 1988 Arch. Biochem. Biophys. pmid:3355155
Yoshida I et al. Formation of a stable and catalytically active complex of the two essential components of hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26. 1989 Biochem. Biophys. Res. Commun. pmid:2541701
Fujisaki S et al. Isolation and characterization of an Escherichia coli mutant having temperature-sensitive farnesyl diphosphate synthase. 1989 J. Bacteriol. pmid:2676985
Croteau R and Purkett PT Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis). 1989 Arch. Biochem. Biophys. pmid:2730002
Sagami H et al. The biosynthesis of dehydrodolichyl phosphates by rat liver microsomes. 1989 Biochim. Biophys. Acta pmid:2930770
Hohn TM and Plattner RD Purification and characterization of the sesquiterpene cyclase aristolochene synthase from Penicillium roqueforti. 1989 Arch. Biochem. Biophys. pmid:2544140
Light DR and Dennis MS Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis. 1989 J. Biol. Chem. pmid:2808388
Light DR et al. Rubber elongation by farnesyl pyrophosphate synthases involves a novel switch in enzyme stereospecificity. 1989 J. Biol. Chem. pmid:2808389
Yoshida I et al. Protection of hexaprenyl-diphosphate synthase of Micrococcus luteus B-P 26 against inactivation by sulphydryl reagents and arginine-specific reagents. 1989 Biochim. Biophys. Acta pmid:2539196
Schafer WR et al. Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. 1990 Science pmid:2204115
Mbaya B et al. Isoprenoid metabolism in Plasmodium falciparum during the intraerythrocytic phase of malaria. 1990 Biochem. Biophys. Res. Commun. pmid:2268347
Reiss Y et al. Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. 1990 Cell pmid:2194674
Tanaka RD et al. Purification and regulation of mevalonate kinase from rat liver. 1990 J. Biol. Chem. pmid:2153681
Schaber MD et al. Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase. 1990 J. Biol. Chem. pmid:2203759
Kim R et al. Prenylation of mammalian Ras protein in Xenopus oocytes. 1990 Mol. Cell. Biol. pmid:2233726
Ericsson J et al. Characterization and distribution of cis-prenyl transferase participating in liver microsomal polyisoprenoid biosynthesis. 1991 Eur. J. Biochem. pmid:1765092
Das NP and Allen CM Inhibition of farnesyl transferases from malignant and non-malignant cultured human lymphocytes by prenyl substrate analogues. 1991 Biochem. Biophys. Res. Commun. pmid:1755854
Wolf MJ et al. Golgi-enriched membrane fractions from rat brain and liver contain long-chain polyisoprenyl pyrophosphate phosphatase activity. 1991 Glycobiology pmid:1668143
Cane DE et al. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. 1991 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:1678531
Biller SA et al. Isoprenyl phosphinylformates: new inhibitors of squalene synthetase. 1991 J. Med. Chem. pmid:2061928