Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Agabiti SS et al. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. 2017 Cell Death Dis pmid:28300835
Kosek V et al. High resolution mass spectrometry based method applicable for a wide range of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors in blood serum including intermediates and products of the cholesterol biosynthetic pathway. 2017 J Chromatogr A pmid:28209347
Mendez-Perez D et al. Production of jet fuel precursor monoterpenoids from engineered Escherichia coli. 2017 Biotechnol. Bioeng. pmid:28369701
Qian J et al. Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants. 2017 BMC Mol. Biol. pmid:28160774
Terabe K et al. Simvastatin inhibits CD44 fragmentation in chondrocytes. 2016 Arch. Biochem. Biophys. pmid:27242325
Matsumoto Y et al. A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus. 2016 Sci Rep pmid:26961421
Pastar I et al. Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration. 2016 J. Cell. Physiol. pmid:26916741
Wong MJ et al. Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27694473
Yang J et al. Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats. 2016 Cell. Physiol. Biochem. pmid:27336844
Grundy DJ et al. Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture. 2016 Biochemistry pmid:26998816
Jennings BC et al. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. 2016 Bioorg. Med. Chem. Lett. pmid:26803203
Pant A and Kocarek TA Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes. 2016 Drug Metab. Dispos. pmid:26700959
Nyati P et al. Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes. 2015 PLoS ONE pmid:26566274
Henry LK et al. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26216978
Sharon C et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. 2015 Oncotarget pmid:25895029
ElAzzouny MA et al. Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells. 2015 PLoS ONE pmid:26107620
Ferriols VM et al. Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera. 2015 Sci Rep pmid:25996801
Harris GG et al. Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. 2015 Biochemistry pmid:26598179
Srivastava PL et al. Functional Characterization of Novel Sesquiterpene Synthases from Indian Sandalwood, Santalum album. 2015 Sci Rep pmid:25976282
Rising KA et al. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. 2015 ACS Chem. Biol. pmid:25897591
Danley DE et al. Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase. 2015 Protein Sci. pmid:25287857
Han X et al. Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. 2015 Proteins pmid:24895191
Liu CI et al. Structural insights into the catalytic mechanism of human squalene synthase. 2014 Acta Crystallogr. D Biol. Crystallogr. pmid:24531458
Smith R et al. Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. 2014 PLoS ONE pmid:24416446
Kawasaki Y et al. Thermodynamic evaluation of the binding of bisphosphonates to human farnesyl pyrophosphate synthase. 2014 Chem. Pharm. Bull. pmid:24172032
Nowroozi FF et al. Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly. 2014 Appl. Microbiol. Biotechnol. pmid:24257840
Yang C et al. Simvastatin-enhanced expression of promyogenic nuclear factors and cardiomyogenesis of murine embryonic stem cells. 2014 Vascul. Pharmacol. pmid:24200505
Wood WG et al. Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. 2014 J. Neurochem. pmid:24329875
Hartwig S et al. Expression, purification and activity assay of a patchoulol synthase cDNA variant fused to thioredoxin in Escherichia coli. 2014 Protein Expr. Purif. pmid:24576659
Mabanglo MF et al. Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. 2014 Protein Sci. pmid:24347326
Du CQ et al. Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine-induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats. 2014 Hypertens. Res. pmid:23985701
Gonzalez V et al. Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase. 2014 J. Am. Chem. Soc. pmid:25230152
Dozier JK et al. Engineering protein farnesyltransferase for enzymatic protein labeling applications. 2014 Bioconjug. Chem. pmid:24946229
Alcaíno J et al. Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors. 2014 PLoS ONE pmid:24796858
Shang N et al. Squalene synthase as a target for Chagas disease therapeutics. 2014 PLoS Pathog. pmid:24789335
Yokoyama T et al. Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate. 2014 Acta Crystallogr F Struct Biol Commun pmid:24699741
Nguyen HT et al. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. 2013 Plant Physiol. Biochem. pmid:24036394
Zhang J et al. Statins directly suppress cytokine production in murine intraepithelial lymphocytes. 2013 Cytokine pmid:23290865
Wang C et al. Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. 2013 Metab. Eng. pmid:23608473
Huang X et al. Identification and characterization of (E)-β-caryophyllene synthase and α/β-pinene synthase potentially involved in constitutive and herbivore-induced terpene formation in cotton. 2013 Plant Physiol. Biochem. pmid:24184450
Frick S et al. Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23440195
Yang CQ et al. Isolation and characterization of terpene synthases in cotton (Gossypium hirsutum). 2013 Phytochemistry pmid:24074555
Vervacke JS et al. Photoactive analogs of farnesyl diphosphate and related isoprenoids: design and applications in studies of medicinally important isoprenoid-utilizing enzymes. 2013 Curr. Med. Chem. pmid:23409719
Lee SK and Kim YS Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. 2013 Int. J. Oncol. pmid:23354132
Lan JB et al. Molecular cloning and expression of Hedychium coronarium farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral and wounding/herbivory induced leaf volatile sesquiterpenoids. 2013 Gene pmid:23333605
Valente AJ et al. Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. 2013 Cell. Signal. pmid:23541442
Xiao H et al. Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. 2013 PLoS ONE pmid:23555637
O'Mullane LM et al. Co-cultures provide a new tool to probe communication between adult sensory neurons and urothelium. 2013 J. Urol. pmid:23353045
Bhardwaj S et al. Muscular effects of statins in the elderly female: a review. 2013 Clin Interv Aging pmid:23355775
Hong WK et al. Characterization of a squalene synthase from the thraustochytrid microalga Aurantiochytrium sp. KRS101. 2013 J. Microbiol. Biotechnol. pmid:23676912