Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Feld BK and Weiss GA Convenient methods for the synthesis of P1-farnesyl-P2-indicator diphosphates. 2006 Bioorg. Med. Chem. Lett. pmid:16406516
Liliom K et al. Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs. 2006 Biochim. Biophys. Acta pmid:17092771
Suzuki T et al. Direct observation of substrate-enzyme complexation by surface forces measurement. 2006 J. Am. Chem. Soc. pmid:17117872
Cane DE How to evolve a silk purse from a sow's ear. 2006 Nat. Chem. Biol. pmid:16547477
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Jiang J et al. Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. 2006 J. Am. Chem. Soc. pmid:16787064
Lin X et al. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. 2006 J. Am. Chem. Soc. pmid:16669656
Gutta P and Tantillo DJ Theoretical studies on farnesyl cation cyclization: pathways to pentalenene. 2006 J. Am. Chem. Soc. pmid:16669687
Sakoda K et al. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. 2006 J. Dent. Res. pmid:16723648
Kim SH et al. Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis. 2006 J. Nat. Prod. pmid:16724836
Schnee C et al. The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16418295
Kavanagh KL et al. The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. 2006 J. Biol. Chem. pmid:16698791
Troutman JM et al. Tools to analyze protein farnesylation in cells. 2005 Sep-Oct Bioconjug. Chem. pmid:16173800
Henriksen BS et al. Computational and conformational evaluation of FTase alternative substrates: insight into a novel enzyme binding pocket. 2005 Jul-Aug J Chem Inf Model pmid:16045300
da Costa BM et al. Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor. 2005 Jan-Feb Biomacromolecules pmid:15638531
Murthy S et al. Regulation of fatty acid synthesis by farnesyl pyrophosphate. 2005 J. Biol. Chem. pmid:16221687
Reigard SA et al. Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase. 2005 Biochemistry pmid:16101305
van de Donk NW et al. Geranylgeranylated proteins are involved in the regulation of myeloma cell growth. 2005 Clin. Cancer Res. pmid:15701825
Ota K et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. 2005 Metab. Clin. Exp. pmid:15690306