Weivoda MM and Hohl RJ |
Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. |
2011 |
Endocrinology |
pmid:21586555
|
Dong X et al. |
Quantitative proteomic analysis revealed lovastatin-induced perturbation of cellular pathways in HL-60 cells. |
2011 |
J. Proteome Res. |
pmid:21967149
|
Cluis CP et al. |
Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). |
2011 |
Metab. Eng. |
pmid:21986057
|
Sasaki D et al. |
Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation. |
2011 |
J. Biol. Chem. |
pmid:21068379
|
Engels B et al. |
Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. |
2011 |
J. Biol. Chem. |
pmid:21148562
|
Nakano C et al. |
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. |
2011 |
J. Biol. Chem. |
pmid:21693706
|
Placzek AT and Gibbs RA |
New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs. |
2011 |
Org. Lett. |
pmid:21699139
|
Holstein SA et al. |
Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. |
2011 |
Lipids |
pmid:21633866
|
Bang S et al. |
Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. |
2011 |
Pain |
pmid:21353389
|
Clastre M et al. |
Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. |
2011 |
Plant Signal Behav |
pmid:22080790
|
Wong DH et al. |
Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. |
2011 |
Fertil. Steril. |
pmid:21907337
|
Schmidt A et al. |
Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). |
2011 |
Plant Mol. Biol. |
pmid:22002747
|
Brown AJ |
Isoprenoid is a perfect fit for fat factor. |
2011 |
Biochem. J. |
pmid:21793802
|
Schaafsma D et al. |
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. |
2011 |
Respir. Res. |
pmid:21864337
|
Leichner GS et al. |
Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. |
2011 |
J. Biol. Chem. |
pmid:21778231
|
Wasko BM et al. |
A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. |
2011 |
J. Lipid Res. |
pmid:21903868
|
Pani A et al. |
Computational identification of sweet wormwood (Artemisia annua) microRNA and their mRNA targets. |
2011 |
Genomics Proteomics Bioinformatics |
pmid:22289476
|
Wang C et al. |
Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. |
2010 |
Biotechnol. Bioeng. |
pmid:20552672
|
Vukelic S et al. |
Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. |
2010 |
J. Biol. Chem. |
pmid:19903814
|
Lu YP et al. |
Mechanism of cis-prenyltransferase reaction probed by substrate analogues. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20828539
|
Koohang A et al. |
Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. |
2010 |
J. Org. Chem. |
pmid:20545375
|
Holstein SA et al. |
Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. |
2010 |
Leuk. Res. |
pmid:19646757
|
Hooff GP et al. |
A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS. |
2010 |
Anal Bioanal Chem |
pmid:20730526
|
Goyanka R et al. |
Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate. |
2010 |
Protein Eng. Des. Sel. |
pmid:20817759
|
Adams VR et al. |
Anticancer activity of novel unnatural synthetic isoprenoids. |
2010 |
Anticancer Res. |
pmid:20682975
|
Rojruthai P et al. |
In vitro synthesis of high molecular weight rubber by Hevea small rubber particles. |
2010 |
J. Biosci. Bioeng. |
pmid:20129092
|
Schmidt A et al. |
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies. |
2010 |
Plant Physiol. |
pmid:19939949
|
Singkaravanit S et al. |
Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi. |
2010 |
Appl. Microbiol. Biotechnol. |
pmid:19690851
|
Kato S et al. |
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. |
2010 |
J. Cell. Mol. Med. |
pmid:19432822
|
Faraldos JA et al. |
Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate. |
2010 |
J. Am. Chem. Soc. |
pmid:20201526
|
Bang S et al. |
Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. |
2010 |
J. Biol. Chem. |
pmid:20395302
|
Hooff GP et al. |
Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. |
2010 |
Mol. Neurobiol. |
pmid:20405344
|
Schramek N et al. |
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. |
2010 |
Phytochemistry |
pmid:19932496
|
Hovlid ML et al. |
Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. |
2010 |
Chem Biol Drug Des |
pmid:19954434
|
Woo IS et al. |
Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. |
2010 |
Neurosci. Lett. |
pmid:20298756
|
Chou WK et al. |
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol. |
2010 |
J. Am. Chem. Soc. |
pmid:20536237
|
Willot M and Christmann M |
Total synthesis: towards artificial terpene cyclases. |
2010 |
Nat Chem |
pmid:20571563
|
Lee SH et al. |
Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain. |
2010 |
Int J Mol Sci |
pmid:21152313
|
Faraldos JA et al. |
Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. |
2010 |
J. Am. Chem. Soc. |
pmid:20148554
|
Morofuji Y et al. |
Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells. |
2010 |
Cell. Mol. Neurobiol. |
pmid:20127168
|
Asadollahi MA et al. |
Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. |
2010 |
Biotechnol. Bioeng. |
pmid:20091767
|
Miriyala S et al. |
Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. |
2010 |
J. Biol. Chem. |
pmid:20110354
|
Duez S et al. |
Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues. |
2010 |
Bioorg. Med. Chem. |
pmid:20036564
|
Lopez-Gallego F et al. |
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. |
2010 |
Chembiochem |
pmid:20419721
|
Lee SK et al. |
Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20043868
|
Lee M et al. |
P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. |
2009 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:19679818
|
Uchida H et al. |
Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L. |
2009 |
Planta |
pmid:19283408
|
Vandermoten S et al. |
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase. |
2009 |
Insect Biochem. Mol. Biol. |
pmid:19720147
|
Holstein SA et al. |
Quantitative determination of geranyl diphosphate levels in cultured human cells. |
2009 |
Lipids |
pmid:19856009
|
Rothwell C et al. |
Cholesterol biosynthesis modulation regulates dengue viral replication. |
2009 |
Virology |
pmid:19419745
|
Liu H et al. |
Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. |
2009 |
Cancer Chemother. Pharmacol. |
pmid:18766339
|
Lu YP et al. |
Different reaction mechanisms for cis- and trans-prenyltransferases. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19103164
|
Sillero MA et al. |
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. |
2009 |
Biochem. Pharmacol. |
pmid:19414000
|
Miller DJ et al. |
6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase. |
2009 |
Org. Biomol. Chem. |
pmid:19225680
|
Cao L et al. |
An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19168029
|
Nonaka M et al. |
Role for protein geranylgeranylation in adult T-cell leukemia cell survival. |
2009 |
Exp. Cell Res. |
pmid:18992741
|
Seong KY et al. |
Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. |
2009 |
Mol. Microbiol. |
pmid:19320833
|
Maeda S et al. |
Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. |
2009 |
J. Pharmacol. Sci. |
pmid:19352075
|
Garza RM et al. |
Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. |
2009 |
J. Biol. Chem. |
pmid:19776008
|
Hong YJ and Tantillo DJ |
Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog. |
2009 |
Org. Biomol. Chem. |
pmid:19763318
|
Sallaud C et al. |
A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. |
2009 |
Plant Cell |
pmid:19155349
|
Henry O et al. |
A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes. |
2009 |
Bioorg. Med. Chem. |
pmid:19447628
|
Wang CM et al. |
Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol. |
2009 |
J. Am. Chem. Soc. |
pmid:19476353
|
Rzepczynska IJ et al. |
Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. |
2009 |
Biol. Reprod. |
pmid:19571257
|
Coudray L et al. |
Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase. |
2009 |
J Enzyme Inhib Med Chem |
pmid:19555171
|
Harada H and Misawa N |
Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli. |
2009 |
Appl. Microbiol. Biotechnol. |
pmid:19672590
|
Kim SE et al. |
Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. |
2009 |
Exp. Mol. Med. |
pmid:19299917
|
Zhao B et al. |
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site. |
2009 |
J. Biol. Chem. |
pmid:19858213
|
Eckert GP et al. |
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. |
2009 |
Neurobiol. Dis. |
pmid:19464372
|
Bradshaw HB et al. |
Orphan endogenous lipids and orphan GPCRs: a good match. |
2009 |
Prostaglandins Other Lipid Mediat. |
pmid:19379823
|
Fujikura K et al. |
Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs. |
2008 |
Biosci. Biotechnol. Biochem. |
pmid:18323637
|
Liu CI et al. |
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. |
2008 |
Science |
pmid:18276850
|
Ogunwobi OO and Beales IL |
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. |
2008 |
Am. J. Gastroenterol. |
pmid:18371146
|
Shishova EY et al. |
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. |
2008 |
J. Biol. Chem. |
pmid:18385128
|
Xie W et al. |
Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species. |
2008 |
Phytochemistry |
pmid:18799172
|
Srivastava A et al. |
Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. |
2008 |
Infect Disord Drug Targets |
pmid:18473904
|
Tong H et al. |
Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. |
2008 |
Anal. Biochem. |
pmid:18457649
|
Tenta R et al. |
Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells. |
2008 |
Horm. Metab. Res. |
pmid:18563678
|
Wada H et al. |
Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18671946
|
Lodewyk MW et al. |
Computational studies on biosynthetic carbocation rearrangements leading to sativene, cyclosativene, alpha-ylangene, and beta-ylangene. |
2008 |
J. Org. Chem. |
pmid:18681400
|
Sundararaj KP et al. |
Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation. |
2008 |
J. Leukoc. Biol. |
pmid:18625914
|
Tsubaki M et al. |
Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells. |
2008 |
Cancer Sci. |
pmid:17979996
|
Jiang J and Cane DE |
Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin. |
2008 |
J. Am. Chem. Soc. |
pmid:18095692
|
Davidovich-Rikanati R et al. |
Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit. |
2008 |
Plant J. |
pmid:18643974
|
Saito A et al. |
Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
2008 |
Melanoma Res. |
pmid:18337644
|
Baba TT et al. |
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
pmid:18792797
|
Subramanian T et al. |
Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. |
2008 |
Chembiochem |
pmid:18985644
|
Giglio S et al. |
Isolation and characterization of the gene associated with geosmin production in cyanobacteria. |
2008 |
Environ. Sci. Technol. |
pmid:19031897
|
Oh DY et al. |
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. |
2008 |
J. Biol. Chem. |
pmid:18499677
|
Gao L et al. |
Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18441251
|
Liang YJ et al. |
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. |
2008 |
Cardiology |
pmid:18057884
|
Rawat DS et al. |
Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues. |
2008 |
J. Org. Chem. |
pmid:18225915
|
Yu F et al. |
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. |
2008 |
FEBS Lett. |
pmid:18242187
|
Paradise EM et al. |
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. |
2008 |
Biotechnol. Bioeng. |
pmid:18175359
|
Yamashita M et al. |
Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. |
2008 |
J. Endocrinol. |
pmid:18310456
|
Peukert S et al. |
Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18295483
|
Farquharson KL |
A sesquiterpene distress signal transmitted by maize. |
2008 |
Plant Cell |
pmid:18296624
|
Köllner TG et al. |
A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties. |
2008 |
Plant Cell |
pmid:18296628
|
Fu Z et al. |
Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. |
2008 |
Biochemistry |
pmid:18302342
|
MartÃnez-Sales V et al. |
Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. |
2007 Jul-Oct |
Endothelium |
pmid:17922340
|