Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

Download all related citations
Per page 10 20 50 100 | Total 614
Authors Title Published Journal PubMed Link
Clastre M et al. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. 2011 Plant Signal Behav pmid:22080790
Nguyen HT et al. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. 2013 Plant Physiol. Biochem. pmid:24036394
Huang X et al. Identification and characterization of (E)-β-caryophyllene synthase and α/β-pinene synthase potentially involved in constitutive and herbivore-induced terpene formation in cotton. 2013 Plant Physiol. Biochem. pmid:24184450
Bouwmeester HJ et al. Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis. 1999 Plant Physiol. pmid:10482672
Benedict CR et al. The cyclization of farnesyl diphosphate and nerolidyl diphosphate by a purified recombinant delta-cadinene synthase. 2001 Plant Physiol. pmid:11299356
Kang H et al. Identification of natural rubber and characterization of rubber biosynthetic activity in fig tree. 2000 Plant Physiol. pmid:10889262
Schmidt A et al. A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies. 2010 Plant Physiol. pmid:19939949
Wentzinger LF et al. Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. 2002 Plant Physiol. pmid:12226513
Schmidt A et al. Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). 2011 Plant Mol. Biol. pmid:22002747
Davidovich-Rikanati R et al. Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit. 2008 Plant J. pmid:18643974
Nah J et al. Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation. 2001 Plant Cell Physiol. pmid:11522913
Aharoni A et al. Terpenoid metabolism in wild-type and transgenic Arabidopsis plants. 2003 Plant Cell pmid:14630967
Sallaud C et al. A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. 2009 Plant Cell pmid:19155349
Farquharson KL A sesquiterpene distress signal transmitted by maize. 2008 Plant Cell pmid:18296624
Köllner TG et al. A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties. 2008 Plant Cell pmid:18296628
Xie W et al. Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species. 2008 Phytochemistry pmid:18799172
Green S et al. Unusual features of a recombinant apple alpha-farnesene synthase. 2007 Phytochemistry pmid:17140613
Spiteller D et al. Feeding of [5,5-2H(2)]-1-desoxy-D-xylulose and [4,4,6,6,6-2H(5)]-mevalolactone to a geosmin-producing Streptomyces sp. and Fossombronia pusilla. 2002 Phytochemistry pmid:12453575
Bouwmeester HJ et al. Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis. 1999 Phytochemistry pmid:10626375
Yang CQ et al. Isolation and characterization of terpene synthases in cotton (Gossypium hirsutum). 2013 Phytochemistry pmid:24074555
May B et al. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. 2013 Phytochemistry pmid:23954075
Schramek N et al. Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. 2010 Phytochemistry pmid:19932496
Schmidt A and Gershenzon J Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation. 2007 Phytochemistry pmid:17624381
Cane DE et al. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. 1991 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:1678531
Bang S et al. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. 2011 Pain pmid:21353389
Rawat DS and Gibbs RA Synthesis of 7-substituted farnesyl diphosphate analogues. 2002 Org. Lett. pmid:12201708
Shao Y et al. Stereospecific synthesis and biological evaluation of farnesyl diphosphate isomers. 1999 Org. Lett. pmid:10823190
Rozema DB et al. Yeast protein farnesyltransferase. Binding of S-alkyl peptides and related analogues. 1999 Org. Lett. pmid:10823210
Placzek AT et al. Synthesis of frame-shifted farnesyl diphosphate analogs. 2012 Org. Lett. pmid:22857735
Placzek AT and Gibbs RA New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs. 2011 Org. Lett. pmid:21699139
Subramanian T et al. Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis. 2005 Org. Lett. pmid:15901146
van Klink J et al. Biosynthesis of anthecotuloide, an irregular sesquiterpene lactone from Anthemis cotula L. (Asteraceae) via a non-farnesyl diphosphate route. 2003 Org. Biomol. Chem. pmid:12926279
Miller DJ et al. 6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase. 2009 Org. Biomol. Chem. pmid:19225680
Hong YJ and Tantillo DJ Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog. 2009 Org. Biomol. Chem. pmid:19763318
Miller DJ et al. Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity. 2007 Org. Biomol. Chem. pmid:17912381
Sharon C et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. 2015 Oncotarget pmid:25895029
Notarnicola M et al. Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. 2004 Oncology pmid:15713990
Shaikenov TE et al. Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase. 2001 Jan-Feb Oncol. Rep. pmid:11115593
Ghosh PM et al. Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. 1999 Oncogene pmid:10435593
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Tringali G et al. Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. 2004 Neurosci. Lett. pmid:14698450
Woo IS et al. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. 2010 Neurosci. Lett. pmid:20298756
Eckert GP et al. Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. 2009 Neurobiol. Dis. pmid:19464372
Ikeuchi H et al. Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. 2004 Nephron Exp. Nephrol. pmid:15331935
Inglese J et al. Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 1992 Nature pmid:1522899
Tanaka Y et al. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. 1995 Nature pmid:7753173
Cane DE How to evolve a silk purse from a sow's ear. 2006 Nat. Chem. Biol. pmid:16547477
Dahl RH et al. Engineering dynamic pathway regulation using stress-response promoters. 2013 Nat. Biotechnol. pmid:24142050
Marcos IS et al. Sesquiterpenyl indoles. 2013 Nat Prod Rep pmid:24172769
Wilson MC and Moore BS Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. 2012 Nat Prod Rep pmid:22124767