Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Ikeuchi H et al. Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. 2004 Nephron Exp. Nephrol. pmid:15331935
Eckert GP et al. Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. 2009 Neurobiol. Dis. pmid:19464372
Tringali G et al. Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. 2004 Neurosci. Lett. pmid:14698450
Woo IS et al. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. 2010 Neurosci. Lett. pmid:20298756
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Ghosh PM et al. Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. 1999 Oncogene pmid:10435593
Shaikenov TE et al. Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase. 2001 Jan-Feb Oncol. Rep. pmid:11115593
Notarnicola M et al. Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. 2004 Oncology pmid:15713990
Sharon C et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. 2015 Oncotarget pmid:25895029
van Klink J et al. Biosynthesis of anthecotuloide, an irregular sesquiterpene lactone from Anthemis cotula L. (Asteraceae) via a non-farnesyl diphosphate route. 2003 Org. Biomol. Chem. pmid:12926279
Miller DJ et al. 6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase. 2009 Org. Biomol. Chem. pmid:19225680
Hong YJ and Tantillo DJ Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog. 2009 Org. Biomol. Chem. pmid:19763318
Miller DJ et al. Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity. 2007 Org. Biomol. Chem. pmid:17912381
Rawat DS and Gibbs RA Synthesis of 7-substituted farnesyl diphosphate analogues. 2002 Org. Lett. pmid:12201708
Shao Y et al. Stereospecific synthesis and biological evaluation of farnesyl diphosphate isomers. 1999 Org. Lett. pmid:10823190
Rozema DB et al. Yeast protein farnesyltransferase. Binding of S-alkyl peptides and related analogues. 1999 Org. Lett. pmid:10823210
Placzek AT et al. Synthesis of frame-shifted farnesyl diphosphate analogs. 2012 Org. Lett. pmid:22857735
Placzek AT and Gibbs RA New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs. 2011 Org. Lett. pmid:21699139
Subramanian T et al. Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis. 2005 Org. Lett. pmid:15901146
Bang S et al. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. 2011 Pain pmid:21353389