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Phytochemistry |
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Biochemistry |
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Phytochemistry |
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Biochemistry |
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Biochemistry |
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Biochemistry |
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Biochemistry |
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Biochemistry |
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The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores. |
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Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production. |
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Biochemistry |
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Mol. Cells |
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Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2). |
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Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. |
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Biochem. Biophys. Res. Commun. |
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Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity. |
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Acta Crystallogr. D Biol. Crystallogr. |
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2004 |
Oncology |
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A novel approach to prezizaane sesquiterpenes. |
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Chem. Biodivers. |
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Differential effects of simvastatin on mesangial cells. |
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Kidney Int. |
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Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis. |
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Anticancer Drugs |
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Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate. |
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Bioorg. Med. Chem. Lett. |
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Chem. Commun. (Camb.) |
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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (pravastatin) inhibits endothelial cell proliferation dependent on G1 cell cycle arrest. |
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Anticancer Drugs |
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Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways. |
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Circ. Res. |
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Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase. |
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Bioorg. Med. Chem. Lett. |
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Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway. |
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J. Bacteriol. |
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Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells. |
2004 |
Am. J. Physiol. Heart Circ. Physiol. |
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Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. |
2004 |
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Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B. |
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Arch. Biochem. Biophys. |
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Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies. |
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Protein Sci. |
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Evidence for differential folding of farnesyl pyrophosphate in the active site of aristolochene synthase: a single-point mutation converts aristolochene synthase into an (E)-beta-farnesene synthase. |
2003 |
Biochemistry |
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A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. |
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J. Med. Chem. |
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