Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Willot M and Christmann M Total synthesis: towards artificial terpene cyclases. 2010 Nat Chem pmid:20571563
Yonemoto M et al. J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner. 1998 Mol. Pharmacol. pmid:9658183
Hooff GP et al. Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. 2012 Mol. Neurobiol. pmid:22692983
Hooff GP et al. Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. 2010 Mol. Neurobiol. pmid:20405344
Seong KY et al. Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. 2009 Mol. Microbiol. pmid:19320833
Teng KH and Liang PH Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. 2012 Mol. Membr. Biol. pmid:22471620
Das S et al. Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors. 2007 Mol. Endocrinol. pmid:17666588
Kim OT et al. Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban. 2005 Mol. Cells pmid:15879717
García-Román N et al. Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. 2001 Mol. Cell. Neurosci. pmid:11178870
Kim R et al. Prenylation of mammalian Ras protein in Xenopus oocytes. 1990 Mol. Cell. Biol. pmid:2233726
Scalcinati G et al. Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae. 2012 Microb. Cell Fact. pmid:22938570
Seabra MC and James GL Prenylation assays for small GTPases. 1998 Methods Mol. Biol. pmid:9666454
Izumo N et al. Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. 2001 Methods Find Exp Clin Pharmacol pmid:11771853
Garrett SR et al. Steady-state kinetic characterization of sesquiterpene synthases by gas chromatography-mass spectroscopy. 2012 Meth. Enzymol. pmid:22999167
Agnew WS Squalene synthetase. 1985 Meth. Enzymol. pmid:3894879
Cox AD Mutation and analysis of prenylation signal sequences. 1995 Meth. Enzymol. pmid:7651143
Thissen JA et al. Prenylated peptides in identification of specific binding proteins. 1995 Meth. Enzymol. pmid:7651148
Reiss Y Substrate interactions of protein prenyltransferases. 1995 Meth. Enzymol. pmid:7651152
Caplin BE and Marshall MS Mutagenesis and biochemical analysis of recombinant yeast prenyltransferases. 1995 Meth. Enzymol. pmid:7651175
Cornish K and Xie W Natural rubber biosynthesis in plants: rubber transferase. 2012 Meth. Enzymol. pmid:22999170
Epand RM et al. Lipid-mediated a-factor interactions with artificial membranes. 1995 Meth. Enzymol. pmid:7651149
Wang C et al. Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. 2013 Metab. Eng. pmid:23608473
Cluis CP et al. Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). 2011 Metab. Eng. pmid:21986057
Ota K et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. 2005 Metab. Clin. Exp. pmid:15690306
Shellman YG et al. Lovastatin-induced apoptosis in human melanoma cell lines. 2005 Melanoma Res. pmid:15846140
Saito A et al. Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. 2008 Melanoma Res. pmid:18337644
Holstein SA et al. Quantitative determination of geranyl diphosphate levels in cultured human cells. 2009 Lipids pmid:19856009
Holstein SA et al. Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. 2011 Lipids pmid:21633866
Xia Z et al. Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. 2001 Leukemia pmid:11516100
Holstein SA et al. Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. 2010 Leuk. Res. pmid:19646757
Massy ZA et al. Importance of geranylgeranyl pyrophosphate for mesangial cell DNA synthesis. 1999 Kidney Int. Suppl. pmid:10412744
Nishimura M et al. Effect of pravastatin on type IV collagen secretion and mesangial cell proliferation. 1999 Kidney Int. Suppl. pmid:10412748
Heusinger-Ribeiro J et al. Differential effects of simvastatin on mesangial cells. 2004 Kidney Int. pmid:15200425
Swiatkowska M et al. Cerivastatin, a HMG-CoA reductase inhibitor, reduces plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity. 2002 Jpn. J. Pharmacol. pmid:12501010
O'Mullane LM et al. Co-cultures provide a new tool to probe communication between adult sensory neurons and urothelium. 2013 J. Urol. pmid:23353045
Dong X et al. Quantitative proteomic analysis revealed lovastatin-induced perturbation of cellular pathways in HL-60 cells. 2011 J. Proteome Res. pmid:21967149
Kalinowski L et al. Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. 2002 J. Physiol. Pharmacol. pmid:12512694
Jantzen F et al. Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. 2007 J. Physiol. Pharmacol. pmid:17928646
Maeda S et al. Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. 2009 J. Pharmacol. Sci. pmid:19352075
Gao L et al. Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. 2008 J. Pharmacol. Exp. Ther. pmid:18441251
Kim M et al. Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues. 2004 J. Org. Chem. pmid:15549786
Turek TC et al. Synthesis of farnesyl diphosphate analogues containing ether-linked photoactive benzophenones and their application in studies of protein prenyltransferases. 2001 J. Org. Chem. pmid:11348105
Lodewyk MW et al. Computational studies on biosynthetic carbocation rearrangements leading to sativene, cyclosativene, alpha-ylangene, and beta-ylangene. 2008 J. Org. Chem. pmid:18681400
Koohang A et al. Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. 2010 J. Org. Chem. pmid:20545375
Labadie GR et al. Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions. 2007 J. Org. Chem. pmid:17979291
Du Y and Wiemer DF Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis. 2002 J. Org. Chem. pmid:12153272
Phan RM and Poulter CD Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors. 2001 J. Org. Chem. pmid:11578224
Rawat DS et al. Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues. 2008 J. Org. Chem. pmid:18225915
Tanaka T et al. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. 2000 J. Neurosci. pmid:10751437
Wood WG et al. Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. 2014 J. Neurochem. pmid:24329875