| Vukelic S et al. |
Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. |
2010 |
J. Biol. Chem. |
pmid:19903814
|
| Schramek N et al. |
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. |
2010 |
Phytochemistry |
pmid:19932496
|
| Schmidt A et al. |
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies. |
2010 |
Plant Physiol. |
pmid:19939949
|
| Hovlid ML et al. |
Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. |
2010 |
Chem Biol Drug Des |
pmid:19954434
|
| Duez S et al. |
Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues. |
2010 |
Bioorg. Med. Chem. |
pmid:20036564
|
| Lee SK et al. |
Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20043868
|
| Asadollahi MA et al. |
Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. |
2010 |
Biotechnol. Bioeng. |
pmid:20091767
|
| Miriyala S et al. |
Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. |
2010 |
J. Biol. Chem. |
pmid:20110354
|
| Morofuji Y et al. |
Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells. |
2010 |
Cell. Mol. Neurobiol. |
pmid:20127168
|
| Rojruthai P et al. |
In vitro synthesis of high molecular weight rubber by Hevea small rubber particles. |
2010 |
J. Biosci. Bioeng. |
pmid:20129092
|
| Faraldos JA et al. |
Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. |
2010 |
J. Am. Chem. Soc. |
pmid:20148554
|
| Faraldos JA et al. |
Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate. |
2010 |
J. Am. Chem. Soc. |
pmid:20201526
|
| Woo IS et al. |
Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. |
2010 |
Neurosci. Lett. |
pmid:20298756
|
| Reiss Y et al. |
Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. |
1991 |
J. Biol. Chem. |
pmid:2037606
|
| Bang S et al. |
Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. |
2010 |
J. Biol. Chem. |
pmid:20395302
|
| Hooff GP et al. |
Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. |
2010 |
Mol. Neurobiol. |
pmid:20405344
|
| Lopez-Gallego F et al. |
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. |
2010 |
Chembiochem |
pmid:20419721
|
| Chou WK et al. |
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol. |
2010 |
J. Am. Chem. Soc. |
pmid:20536237
|
| Koohang A et al. |
Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. |
2010 |
J. Org. Chem. |
pmid:20545375
|
| Wang C et al. |
Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. |
2010 |
Biotechnol. Bioeng. |
pmid:20552672
|
| Willot M and Christmann M |
Total synthesis: towards artificial terpene cyclases. |
2010 |
Nat Chem |
pmid:20571563
|
| Biller SA et al. |
Isoprenyl phosphinylformates: new inhibitors of squalene synthetase. |
1991 |
J. Med. Chem. |
pmid:2061928
|
| Adams VR et al. |
Anticancer activity of novel unnatural synthetic isoprenoids. |
2010 |
Anticancer Res. |
pmid:20682975
|
| Hooff GP et al. |
A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS. |
2010 |
Anal Bioanal Chem |
pmid:20730526
|
| Goyanka R et al. |
Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate. |
2010 |
Protein Eng. Des. Sel. |
pmid:20817759
|
| Lu YP et al. |
Mechanism of cis-prenyltransferase reaction probed by substrate analogues. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20828539
|
| Sasaki D et al. |
Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation. |
2011 |
J. Biol. Chem. |
pmid:21068379
|
| Engels B et al. |
Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. |
2011 |
J. Biol. Chem. |
pmid:21148562
|
| Lee SH et al. |
Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain. |
2010 |
Int J Mol Sci |
pmid:21152313
|
| Von Zee CL and Stubbs EB |
Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells. |
2011 |
Invest. Ophthalmol. Vis. Sci. |
pmid:21212187
|
| Mann FM et al. |
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. |
2011 |
FEBS Lett. |
pmid:21237161
|
| Hu Y et al. |
Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases. |
2011 |
Chem. Biol. |
pmid:21276937
|
| Cazzola M et al. |
Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi. |
2011 |
Am. J. Respir. Cell Mol. Biol. |
pmid:21278325
|
| Yokota K et al. |
Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. |
2011 Jan-Feb |
Clin. Exp. Rheumatol. |
pmid:21345291
|
| Bang S et al. |
Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. |
2011 |
Pain |
pmid:21353389
|
| Tanaka RD et al. |
Purification and regulation of mevalonate kinase from rat liver. |
1990 |
J. Biol. Chem. |
pmid:2153681
|
| Weivoda MM and Hohl RJ |
Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. |
2011 |
Endocrinology |
pmid:21586555
|
| Goto T et al. |
Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. |
2011 |
Biochem. J. |
pmid:21605082
|
| Holstein SA et al. |
Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. |
2011 |
Lipids |
pmid:21633866
|
| Nakano C et al. |
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. |
2011 |
J. Biol. Chem. |
pmid:21693706
|
| Placzek AT and Gibbs RA |
New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs. |
2011 |
Org. Lett. |
pmid:21699139
|
| Leichner GS et al. |
Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. |
2011 |
J. Biol. Chem. |
pmid:21778231
|
| Brown AJ |
Isoprenoid is a perfect fit for fat factor. |
2011 |
Biochem. J. |
pmid:21793802
|
| Schaafsma D et al. |
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. |
2011 |
Respir. Res. |
pmid:21864337
|
| Wasko BM et al. |
A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. |
2011 |
J. Lipid Res. |
pmid:21903868
|
| Wong DH et al. |
Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. |
2011 |
Fertil. Steril. |
pmid:21907337
|
| Ortega I et al. |
Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. |
2012 |
Biol. Reprod. |
pmid:21918126
|
| Reiss Y et al. |
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. |
1990 |
Cell |
pmid:2194674
|
| Dong X et al. |
Quantitative proteomic analysis revealed lovastatin-induced perturbation of cellular pathways in HL-60 cells. |
2011 |
J. Proteome Res. |
pmid:21967149
|
| Cluis CP et al. |
Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). |
2011 |
Metab. Eng. |
pmid:21986057
|
| Teng KH and Liang PH |
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis. |
2012 |
Bioorg. Chem. |
pmid:21993493
|
| Schmidt A et al. |
Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). |
2011 |
Plant Mol. Biol. |
pmid:22002747
|
| Schaber MD et al. |
Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase. |
1990 |
J. Biol. Chem. |
pmid:2203759
|
| Schafer WR et al. |
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. |
1990 |
Science |
pmid:2204115
|
| Exnowitz F et al. |
NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves. |
2012 |
Biochim. Biophys. Acta |
pmid:22079737
|
| Clastre M et al. |
Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. |
2011 |
Plant Signal Behav |
pmid:22080790
|
| Wilson MC and Moore BS |
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. |
2012 |
Nat Prod Rep |
pmid:22124767
|
| Moody SC et al. |
Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes. |
2012 |
FEBS J. |
pmid:22151149
|
| Green SA et al. |
Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). |
2012 |
J. Exp. Bot. |
pmid:22162874
|
| Mans RA et al. |
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. |
2012 |
Neuroscience |
pmid:22192838
|
| Nagel R et al. |
Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. |
2012 |
Anal. Biochem. |
pmid:22266300
|
| Pani A et al. |
Computational identification of sweet wormwood (Artemisia annua) microRNA and their mRNA targets. |
2011 |
Genomics Proteomics Bioinformatics |
pmid:22289476
|
| Kim R et al. |
Prenylation of mammalian Ras protein in Xenopus oocytes. |
1990 |
Mol. Cell. Biol. |
pmid:2233726
|
| Baadhe RR et al. |
Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. |
2012 |
Appl. Biochem. Biotechnol. |
pmid:22350871
|
| Faraldos JA et al. |
A 1,6-ring closure mechanism for (+)-δ-cadinene synthase? |
2012 |
J. Am. Chem. Soc. |
pmid:22397618
|
| Teng KH and Liang PH |
Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. |
2012 |
Mol. Membr. Biol. |
pmid:22471620
|
| Sokalska A et al. |
Simvastatin decreases invasiveness of human endometrial stromal cells. |
2012 |
Biol. Reprod. |
pmid:22492974
|
| Högberg C et al. |
Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Yâ‚â‚‚ receptor-mediated platelet aggregation. |
2012 |
Thromb. Haemost. |
pmid:22628078
|
| Mbaya B et al. |
Isoprenoid metabolism in Plasmodium falciparum during the intraerythrocytic phase of malaria. |
1990 |
Biochem. Biophys. Res. Commun. |
pmid:2268347
|
| Hooff GP et al. |
Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. |
2012 |
Mol. Neurobiol. |
pmid:22692983
|
| Zhang YL and Li ZX |
Functional analysis and molecular docking identify two active short-chain prenyltransferases in the green peach aphid, Myzus persicae. |
2012 |
Arch. Insect Biochem. Physiol. |
pmid:22696503
|
| Melillo E et al. |
Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous. |
2012 |
J. Biotechnol. |
pmid:22771888
|
| Bitok JK and Meyers CF |
2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity. |
2012 |
ACS Chem. Biol. |
pmid:22839733
|
| Placzek AT et al. |
Synthesis of frame-shifted farnesyl diphosphate analogs. |
2012 |
Org. Lett. |
pmid:22857735
|
| Kera K et al. |
Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana. |
2012 |
FEBS J. |
pmid:22883514
|
| Lujan DK et al. |
Chemoenzymatic synthesis of an isoprenoid phosphate tool for the analysis of complex bacterial oligosaccharide biosynthesis. |
2012 |
Carbohydr. Res. |
pmid:22925763
|
| Scalcinati G et al. |
Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae. |
2012 |
Microb. Cell Fact. |
pmid:22938570
|
| Gopalan A et al. |
Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. |
2013 |
Cancer Lett. |
pmid:22960596
|
| Zhang J et al. |
Modeling studies with Helicobacter pylori octaprenyl pyrophosphate synthase reveal the enzymatic mechanism of trans-prenyltransferases. |
2012 |
Int. J. Biochem. Cell Biol. |
pmid:22982238
|
| Subramanian T et al. |
Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. |
2012 |
Biochemistry |
pmid:22989235
|
| Garrett SR et al. |
Steady-state kinetic characterization of sesquiterpene synthases by gas chromatography-mass spectroscopy. |
2012 |
Meth. Enzymol. |
pmid:22999167
|
| Cornish K and Xie W |
Natural rubber biosynthesis in plants: rubber transferase. |
2012 |
Meth. Enzymol. |
pmid:22999170
|
| Takami T et al. |
A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. |
2012 |
PLoS ONE |
pmid:23145048
|
| Keim V et al. |
Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. |
2012 |
PLoS ONE |
pmid:23145086
|
| Bleeker PM et al. |
Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative. |
2012 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23169639
|
| Vega-Pérez JM et al. |
Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: synthesis and in vitro antimicrobial and cytotoxic activities. |
2012 |
Eur J Med Chem |
pmid:23174318
|
| Faraldos JA et al. |
Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases. |
2012 |
J. Am. Chem. Soc. |
pmid:23214943
|
| Zhang J et al. |
Statins directly suppress cytokine production in murine intraepithelial lymphocytes. |
2013 |
Cytokine |
pmid:23290865
|
| Lan JB et al. |
Molecular cloning and expression of Hedychium coronarium farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral and wounding/herbivory induced leaf volatile sesquiterpenoids. |
2013 |
Gene |
pmid:23333605
|
| O'Mullane LM et al. |
Co-cultures provide a new tool to probe communication between adult sensory neurons and urothelium. |
2013 |
J. Urol. |
pmid:23353045
|
| Lee SK and Kim YS |
Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. |
2013 |
Int. J. Oncol. |
pmid:23354132
|
| Bhardwaj S et al. |
Muscular effects of statins in the elderly female: a review. |
2013 |
Clin Interv Aging |
pmid:23355775
|
| Vervacke JS et al. |
Photoactive analogs of farnesyl diphosphate and related isoprenoids: design and applications in studies of medicinally important isoprenoid-utilizing enzymes. |
2013 |
Curr. Med. Chem. |
pmid:23409719
|
| Frick S et al. |
Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23440195
|
| Valente AJ et al. |
Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. |
2013 |
Cell. Signal. |
pmid:23541442
|
| Xiao H et al. |
Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. |
2013 |
PLoS ONE |
pmid:23555637
|
| Wang C et al. |
Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. |
2013 |
Metab. Eng. |
pmid:23608473
|
| Hong WK et al. |
Characterization of a squalene synthase from the thraustochytrid microalga Aurantiochytrium sp. KRS101. |
2013 |
J. Microbiol. Biotechnol. |
pmid:23676912
|
| Mahmoodi MM et al. |
Chemoenzymatic site-specific reversible immobilization and labeling of proteins from crude cellular extract without prior purification using oxime and hydrazine ligation. |
2013 |
Curr Protoc Chem Biol |
pmid:23839992
|
| Chen M et al. |
Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. |
2013 |
Biochemistry |
pmid:23905850
|
