Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

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What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

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Authors Title Published Journal PubMed Link
Lee M et al. P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19679818
Uchida H et al. Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L. 2009 Planta pmid:19283408
Vandermoten S et al. Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase. 2009 Insect Biochem. Mol. Biol. pmid:19720147
Holstein SA et al. Quantitative determination of geranyl diphosphate levels in cultured human cells. 2009 Lipids pmid:19856009
Rothwell C et al. Cholesterol biosynthesis modulation regulates dengue viral replication. 2009 Virology pmid:19419745
Liu H et al. Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. 2009 Cancer Chemother. Pharmacol. pmid:18766339
Lu YP et al. Different reaction mechanisms for cis- and trans-prenyltransferases. 2009 Biochem. Biophys. Res. Commun. pmid:19103164
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
Miller DJ et al. 6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase. 2009 Org. Biomol. Chem. pmid:19225680
Cao L et al. An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase. 2009 Biochem. Biophys. Res. Commun. pmid:19168029
Nonaka M et al. Role for protein geranylgeranylation in adult T-cell leukemia cell survival. 2009 Exp. Cell Res. pmid:18992741
Seong KY et al. Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. 2009 Mol. Microbiol. pmid:19320833
Maeda S et al. Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. 2009 J. Pharmacol. Sci. pmid:19352075
Garza RM et al. Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. 2009 J. Biol. Chem. pmid:19776008
Hong YJ and Tantillo DJ Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog. 2009 Org. Biomol. Chem. pmid:19763318
Sallaud C et al. A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. 2009 Plant Cell pmid:19155349
Kim SE et al. Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. 2009 Exp. Mol. Med. pmid:19299917
Zhao B et al. Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site. 2009 J. Biol. Chem. pmid:19858213
Eckert GP et al. Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. 2009 Neurobiol. Dis. pmid:19464372
Bradshaw HB et al. Orphan endogenous lipids and orphan GPCRs: a good match. 2009 Prostaglandins Other Lipid Mediat. pmid:19379823
Fujikura K et al. Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs. 2008 Biosci. Biotechnol. Biochem. pmid:18323637
Liu CI et al. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. 2008 Science pmid:18276850
Ogunwobi OO and Beales IL Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. 2008 Am. J. Gastroenterol. pmid:18371146
Shishova EY et al. X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. 2008 J. Biol. Chem. pmid:18385128
Xie W et al. Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species. 2008 Phytochemistry pmid:18799172
Srivastava A et al. Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. 2008 Infect Disord Drug Targets pmid:18473904
Tong H et al. Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. 2008 Anal. Biochem. pmid:18457649
Tenta R et al. Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells. 2008 Horm. Metab. Res. pmid:18563678
Wada H et al. Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. 2008 Biochem. Biophys. Res. Commun. pmid:18671946
Lodewyk MW et al. Computational studies on biosynthetic carbocation rearrangements leading to sativene, cyclosativene, alpha-ylangene, and beta-ylangene. 2008 J. Org. Chem. pmid:18681400
Sundararaj KP et al. Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation. 2008 J. Leukoc. Biol. pmid:18625914
Tsubaki M et al. Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells. 2008 Cancer Sci. pmid:17979996
Jiang J and Cane DE Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin. 2008 J. Am. Chem. Soc. pmid:18095692
Davidovich-Rikanati R et al. Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit. 2008 Plant J. pmid:18643974
Saito A et al. Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. 2008 Melanoma Res. pmid:18337644
Baba TT et al. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. 2008 J. Muscle Res. Cell. Motil. pmid:18792797
Subramanian T et al. Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. 2008 Chembiochem pmid:18985644
Giglio S et al. Isolation and characterization of the gene associated with geosmin production in cyanobacteria. 2008 Environ. Sci. Technol. pmid:19031897
Oh DY et al. Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. 2008 J. Biol. Chem. pmid:18499677
Gao L et al. Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. 2008 J. Pharmacol. Exp. Ther. pmid:18441251
Liang YJ et al. Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. 2008 Cardiology pmid:18057884
Rawat DS et al. Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues. 2008 J. Org. Chem. pmid:18225915
Yu F et al. Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. 2008 FEBS Lett. pmid:18242187
Paradise EM et al. Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. 2008 Biotechnol. Bioeng. pmid:18175359
Yamashita M et al. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. 2008 J. Endocrinol. pmid:18310456
Peukert S et al. Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. 2008 Bioorg. Med. Chem. Lett. pmid:18295483
Farquharson KL A sesquiterpene distress signal transmitted by maize. 2008 Plant Cell pmid:18296624
Köllner TG et al. A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties. 2008 Plant Cell pmid:18296628
Fu Z et al. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. 2008 Biochemistry pmid:18302342
Martínez-Sales V et al. Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. 2007 Jul-Oct Endothelium pmid:17922340