Lee M et al. |
P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. |
2009 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:19679818
|
Uchida H et al. |
Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L. |
2009 |
Planta |
pmid:19283408
|
Vandermoten S et al. |
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase. |
2009 |
Insect Biochem. Mol. Biol. |
pmid:19720147
|
Holstein SA et al. |
Quantitative determination of geranyl diphosphate levels in cultured human cells. |
2009 |
Lipids |
pmid:19856009
|
Rothwell C et al. |
Cholesterol biosynthesis modulation regulates dengue viral replication. |
2009 |
Virology |
pmid:19419745
|
Liu H et al. |
Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. |
2009 |
Cancer Chemother. Pharmacol. |
pmid:18766339
|
Lu YP et al. |
Different reaction mechanisms for cis- and trans-prenyltransferases. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19103164
|
Sillero MA et al. |
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. |
2009 |
Biochem. Pharmacol. |
pmid:19414000
|
Miller DJ et al. |
6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase. |
2009 |
Org. Biomol. Chem. |
pmid:19225680
|
Cao L et al. |
An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase. |
2009 |
Biochem. Biophys. Res. Commun. |
pmid:19168029
|
Nonaka M et al. |
Role for protein geranylgeranylation in adult T-cell leukemia cell survival. |
2009 |
Exp. Cell Res. |
pmid:18992741
|
Seong KY et al. |
Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. |
2009 |
Mol. Microbiol. |
pmid:19320833
|
Maeda S et al. |
Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. |
2009 |
J. Pharmacol. Sci. |
pmid:19352075
|
Garza RM et al. |
Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. |
2009 |
J. Biol. Chem. |
pmid:19776008
|
Hong YJ and Tantillo DJ |
Modes of inactivation of trichodiene synthase by a cyclopropane-containing farnesyldiphosphate analog. |
2009 |
Org. Biomol. Chem. |
pmid:19763318
|
Sallaud C et al. |
A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. |
2009 |
Plant Cell |
pmid:19155349
|
Kim SE et al. |
Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. |
2009 |
Exp. Mol. Med. |
pmid:19299917
|
Zhao B et al. |
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site. |
2009 |
J. Biol. Chem. |
pmid:19858213
|
Eckert GP et al. |
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. |
2009 |
Neurobiol. Dis. |
pmid:19464372
|
Bradshaw HB et al. |
Orphan endogenous lipids and orphan GPCRs: a good match. |
2009 |
Prostaglandins Other Lipid Mediat. |
pmid:19379823
|
Fujikura K et al. |
Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs. |
2008 |
Biosci. Biotechnol. Biochem. |
pmid:18323637
|
Liu CI et al. |
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. |
2008 |
Science |
pmid:18276850
|
Ogunwobi OO and Beales IL |
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. |
2008 |
Am. J. Gastroenterol. |
pmid:18371146
|
Shishova EY et al. |
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. |
2008 |
J. Biol. Chem. |
pmid:18385128
|
Xie W et al. |
Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species. |
2008 |
Phytochemistry |
pmid:18799172
|
Srivastava A et al. |
Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target. |
2008 |
Infect Disord Drug Targets |
pmid:18473904
|
Tong H et al. |
Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. |
2008 |
Anal. Biochem. |
pmid:18457649
|
Tenta R et al. |
Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells. |
2008 |
Horm. Metab. Res. |
pmid:18563678
|
Wada H et al. |
Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18671946
|
Lodewyk MW et al. |
Computational studies on biosynthetic carbocation rearrangements leading to sativene, cyclosativene, alpha-ylangene, and beta-ylangene. |
2008 |
J. Org. Chem. |
pmid:18681400
|
Sundararaj KP et al. |
Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation. |
2008 |
J. Leukoc. Biol. |
pmid:18625914
|
Tsubaki M et al. |
Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells. |
2008 |
Cancer Sci. |
pmid:17979996
|
Jiang J and Cane DE |
Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin. |
2008 |
J. Am. Chem. Soc. |
pmid:18095692
|
Davidovich-Rikanati R et al. |
Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit. |
2008 |
Plant J. |
pmid:18643974
|
Saito A et al. |
Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
2008 |
Melanoma Res. |
pmid:18337644
|
Baba TT et al. |
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
2008 |
J. Muscle Res. Cell. Motil. |
pmid:18792797
|
Subramanian T et al. |
Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. |
2008 |
Chembiochem |
pmid:18985644
|
Giglio S et al. |
Isolation and characterization of the gene associated with geosmin production in cyanobacteria. |
2008 |
Environ. Sci. Technol. |
pmid:19031897
|
Oh DY et al. |
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. |
2008 |
J. Biol. Chem. |
pmid:18499677
|
Gao L et al. |
Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18441251
|
Liang YJ et al. |
Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. |
2008 |
Cardiology |
pmid:18057884
|
Rawat DS et al. |
Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues. |
2008 |
J. Org. Chem. |
pmid:18225915
|
Yu F et al. |
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. |
2008 |
FEBS Lett. |
pmid:18242187
|
Paradise EM et al. |
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. |
2008 |
Biotechnol. Bioeng. |
pmid:18175359
|
Yamashita M et al. |
Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. |
2008 |
J. Endocrinol. |
pmid:18310456
|
Peukert S et al. |
Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18295483
|
Farquharson KL |
A sesquiterpene distress signal transmitted by maize. |
2008 |
Plant Cell |
pmid:18296624
|
Köllner TG et al. |
A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties. |
2008 |
Plant Cell |
pmid:18296628
|
Fu Z et al. |
Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. |
2008 |
Biochemistry |
pmid:18302342
|
MartÃnez-Sales V et al. |
Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. |
2007 Jul-Oct |
Endothelium |
pmid:17922340
|