Farnesyl diphosphate

Farnesyl diphosphate is a lipid of Prenol Lipids (PR) class. Farnesyl diphosphate is associated with abnormalities such as Dental caries and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Regulation, Process, Signal, Anabolism and inhibitors. Farnesyl diphosphate often locates in peroxisome, Cytoplasmic matrix, Plasma membrane, soluble and Mitochondria. The associated genes with Farnesyl diphosphate are HSD3B1 gene, ABRA gene, MATN1 gene, SEPSECS gene and MBD2 gene. The related lipids are Sterols, 22-hydroxycholesterol, dehydrosqualene, SK&F 104976 and 25-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of Farnesyl diphosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Farnesyl diphosphate?

Farnesyl diphosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Farnesyl diphosphate

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Osteosarcoma D012516 50 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Protozoan Infections D011528 6 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Farnesyl diphosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Farnesyl diphosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Farnesyl diphosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Farnesyl diphosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Farnesyl diphosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Farnesyl diphosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Farnesyl diphosphate

Download all related citations
Per page 10 20 50 100 | Total 614
Authors Title Published Journal PubMed Link
Bassa BV et al. Effect of inhibition of cholesterol synthetic pathway on the activation of Ras and MAP kinase in mesangial cells. 1999 Biochim. Biophys. Acta pmid:10082972
Liliom K et al. Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs. 2006 Biochim. Biophys. Acta pmid:17092771
Raisig A and Sandmann G Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways. 2001 Biochim. Biophys. Acta pmid:11566453
Koyama T et al. Substrate specificity of squalene synthetase. 1980 Biochim. Biophys. Acta pmid:7357018
Sagami H et al. The biosynthesis of dehydrodolichyl phosphates by rat liver microsomes. 1989 Biochim. Biophys. Acta pmid:2930770
Newman P et al. Polyisoprenylation of the CAAX motif--an in vitro protein synthesis study. 1991 Biochim. Biophys. Acta pmid:1954230
Yoshida I et al. Protection of hexaprenyl-diphosphate synthase of Micrococcus luteus B-P 26 against inactivation by sulphydryl reagents and arginine-specific reagents. 1989 Biochim. Biophys. Acta pmid:2539196
Pan JJ et al. Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis. 2002 Biochim. Biophys. Acta pmid:11825609
Ericsson J et al. Biosynthesis of dolichol and cholesterol in rat liver peroxisomes. 1993 Biochimie pmid:8507678
Troutman JM et al. Tools to analyze protein farnesylation in cells. 2005 Sep-Oct Bioconjug. Chem. pmid:16173800
Dozier JK et al. Engineering protein farnesyltransferase for enzymatic protein labeling applications. 2014 Bioconjug. Chem. pmid:24946229
Sinensky M and Lutz RJ The prenylation of proteins. 1992 Bioessays pmid:1546978
Sokalska A et al. Simvastatin decreases invasiveness of human endometrial stromal cells. 2012 Biol. Reprod. pmid:22492974
Rzepczynska IJ et al. Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. 2009 Biol. Reprod. pmid:19571257
Goalstone ML et al. Characterization of Xenopus laevis oocyte farnesyl transferase. 1996 Biol. Reprod. pmid:8835391
Ortega I et al. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. 2012 Biol. Reprod. pmid:21918126
da Costa BM et al. Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor. 2005 Jan-Feb Biomacromolecules pmid:15638531
Fairlamb IJ et al. Synthesis and antimicrobial evaluation of farnesyl diphosphate mimetics. 2003 Bioorg. Chem. pmid:12697170
Teng KH and Liang PH Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis. 2012 Bioorg. Chem. pmid:21993493
Holstein SA et al. Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase. 1998 Bioorg. Med. Chem. pmid:9681134
Eummer JT et al. Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors. 1999 Bioorg. Med. Chem. pmid:10218815
Henry O et al. A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes. 2009 Bioorg. Med. Chem. pmid:19447628
Duez S et al. Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues. 2010 Bioorg. Med. Chem. pmid:20036564
Christensen DJ and Poulter CD Enzymatic synthesis of isotopically labeled isoprenoid diphosphates. 1994 Bioorg. Med. Chem. pmid:7858969
Scholten JD et al. Inhibitors of farnesyl:protein transferase--a possible cancer chemotherapeutic. 1996 Bioorg. Med. Chem. pmid:8894110
Feld BK and Weiss GA Convenient methods for the synthesis of P1-farnesyl-P2-indicator diphosphates. 2006 Bioorg. Med. Chem. Lett. pmid:16406516
Zhou C et al. Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation. 2002 Bioorg. Med. Chem. Lett. pmid:11992789
Lannuzel M et al. From pure FPP to mixed FPP and CAAX competitive inhibitors of farnesyl protein transferase. 2003 Bioorg. Med. Chem. Lett. pmid:12668012
Zahn TJ et al. Grignard-mediated synthesis and preliminary biological evaluation of novel 3-substituted farnesyl diphosphate analogues. 2000 Bioorg. Med. Chem. Lett. pmid:10937743
Troutman JM et al. Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate. 2004 Bioorg. Med. Chem. Lett. pmid:15341963
Liu XH and Prestwich GD Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase. 2004 Bioorg. Med. Chem. Lett. pmid:15080995
Jennings BC et al. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. 2016 Bioorg. Med. Chem. Lett. pmid:26803203
Peukert S et al. Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. 2008 Bioorg. Med. Chem. Lett. pmid:18295483
Fujikura K et al. Kinetic studies of Micrococcus luteus B-P 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs. 2008 Biosci. Biotechnol. Biochem. pmid:18323637
Karunagoda RP et al. Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus. 2001 Biosci. Biotechnol. Biochem. pmid:11440120
Koyama T Molecular analysis of prenyl chain elongating enzymes. 1999 Biosci. Biotechnol. Biochem. pmid:10586494
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Martin VJ et al. The in vivo synthesis of plant sesquiterpenes by Escherichia coli. 2001 Biotechnol. Bioeng. pmid:11745124
Takahashi S et al. Metabolic engineering of sesquiterpene metabolism in yeast. 2007 Biotechnol. Bioeng. pmid:17013941
Mendez-Perez D et al. Production of jet fuel precursor monoterpenoids from engineered Escherichia coli. 2017 Biotechnol. Bioeng. pmid:28369701
Asadollahi MA et al. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. 2010 Biotechnol. Bioeng. pmid:20091767
Paradise EM et al. Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. 2008 Biotechnol. Bioeng. pmid:18175359
Lindahl AL et al. Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. 2006 Biotechnol. Lett. pmid:16614895
Qian J et al. Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants. 2017 BMC Mol. Biol. pmid:28160774
Eberlein M et al. Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). 2001 Br. J. Pharmacol. pmid:11487529
Liu H et al. Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. 2009 Cancer Chemother. Pharmacol. pmid:18766339
Gopalan A et al. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. 2013 Cancer Lett. pmid:22960596
Nakajima H et al. Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. 2007 Cancer Lett. pmid:17316980
Finlay GA et al. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. 2007 Cancer Res. pmid:17942919
Tsubaki M et al. Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells. 2008 Cancer Sci. pmid:17979996