Takahashi S et al. |
Metabolic engineering of sesquiterpene metabolism in yeast. |
2007 |
Biotechnol. Bioeng. |
pmid:17013941
|
Green S et al. |
Unusual features of a recombinant apple alpha-farnesene synthase. |
2007 |
Phytochemistry |
pmid:17140613
|
Camino-López S et al. |
Tissue factor induction by aggregated LDL depends on LDL receptor-related protein expression (LRP1) and Rho A translocation in human vascular smooth muscle cells. |
2007 |
Cardiovasc. Res. |
pmid:17141748
|
Matsumura Y et al. |
The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. |
2007 |
J. Biochem. |
pmid:17846065
|
Saijonmaa O et al. |
Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. |
2007 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:17158648
|
Wiemer AJ et al. |
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. |
2007 |
Biochem. Biophys. Res. Commun. |
pmid:17208200
|
Guo RT et al. |
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17535895
|
Ling Y et al. |
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. |
2007 |
J. Biol. Chem. |
pmid:17724033
|
Saito K et al. |
Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase. |
2007 |
J. Biosci. Bioeng. |
pmid:17630132
|
Miller DJ et al. |
Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity. |
2007 |
Org. Biomol. Chem. |
pmid:17912381
|
Faraldos JA et al. |
Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. |
2007 |
Chembiochem |
pmid:17886322
|
Jantzen F et al. |
Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. |
2007 |
J. Physiol. Pharmacol. |
pmid:17928646
|
Labadie GR et al. |
Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions. |
2007 |
J. Org. Chem. |
pmid:17979291
|
Cui G and Merz KM |
Computational studies of the farnesyltransferase ternary complex part II: the conformational activation of farnesyldiphosphate. |
2007 |
Biochemistry |
pmid:17918965
|
Finlay GA et al. |
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. |
2007 |
Cancer Res. |
pmid:17942919
|
Nguyen UT et al. |
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. |
2007 |
Chembiochem |
pmid:17279592
|
Sealey-Cardona M et al. |
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives. |
2007 |
Antimicrob. Agents Chemother. |
pmid:17371809
|
Krzysiak AJ et al. |
Combinatorial modulation of protein prenylation. |
2007 |
ACS Chem. Biol. |
pmid:17530735
|
Oswald M et al. |
Monoterpenoid biosynthesis in Saccharomyces cerevisiae. |
2007 |
FEMS Yeast Res. |
pmid:17096665
|
Lee MH et al. |
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. |
2007 |
Stem Cells |
pmid:17464088
|
Kaneko R et al. |
Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. |
2007 |
J. Biol. Chem. |
pmid:17472962
|
Nakajima H et al. |
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. |
2007 |
Cancer Lett. |
pmid:17316980
|
Schmidt A and Gershenzon J |
Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation. |
2007 |
Phytochemistry |
pmid:17624381
|
Kinjoh T et al. |
Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. |
2007 |
Insect Biochem. Mol. Biol. |
pmid:17628279
|
Miller DJ et al. |
Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A. |
2007 |
Chembiochem |
pmid:17683054
|
Das S et al. |
Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors. |
2007 |
Mol. Endocrinol. |
pmid:17666588
|
Qiu G and Hill JS |
Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. |
2007 |
J. Lipid Res. |
pmid:17644777
|
Shishova EY et al. |
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate. |
2007 |
Biochemistry |
pmid:17261032
|
Troutman JM et al. |
Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release. |
2007 |
Biochemistry |
pmid:17877368
|
Troutman JM et al. |
Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues. |
2007 |
Biochemistry |
pmid:17854205
|
Feld BK and Weiss GA |
Convenient methods for the synthesis of P1-farnesyl-P2-indicator diphosphates. |
2006 |
Bioorg. Med. Chem. Lett. |
pmid:16406516
|
Liliom K et al. |
Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs. |
2006 |
Biochim. Biophys. Acta |
pmid:17092771
|
Cusson M et al. |
Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones. |
2006 |
Proteins |
pmid:16972283
|
Pozo M et al. |
Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. |
2006 |
Eur. J. Pharmacol. |
pmid:16973154
|
Dursina B et al. |
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. |
2006 |
J. Am. Chem. Soc. |
pmid:16506760
|
Cane DE et al. |
Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. |
2006 |
J. Antibiot. |
pmid:17080683
|
Suzuki T et al. |
Direct observation of substrate-enzyme complexation by surface forces measurement. |
2006 |
J. Am. Chem. Soc. |
pmid:17117872
|
Cane DE |
How to evolve a silk purse from a sow's ear. |
2006 |
Nat. Chem. Biol. |
pmid:16547477
|
Lindahl AL et al. |
Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. |
2006 |
Biotechnol. Lett. |
pmid:16614895
|
Liang SL et al. |
Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway. |
2006 |
J. Immunol. |
pmid:16785563
|
Jiang J et al. |
Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. |
2006 |
J. Am. Chem. Soc. |
pmid:16787064
|
Kloer DP et al. |
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba. |
2006 |
Biochemistry |
pmid:17176041
|
Lin X et al. |
Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. |
2006 |
J. Am. Chem. Soc. |
pmid:16669656
|
Gutta P and Tantillo DJ |
Theoretical studies on farnesyl cation cyclization: pathways to pentalenene. |
2006 |
J. Am. Chem. Soc. |
pmid:16669687
|
Sakoda K et al. |
Simvastatin decreases IL-6 and IL-8 production in epithelial cells. |
2006 |
J. Dent. Res. |
pmid:16723648
|
Schnee C et al. |
The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16418295
|
Calleros L et al. |
RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion. |
2006 |
Apoptosis |
pmid:16699960
|
Zahiri HS et al. |
Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production. |
2006 |
Appl. Microbiol. Biotechnol. |
pmid:16896603
|
Kavanagh KL et al. |
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. |
2006 |
J. Biol. Chem. |
pmid:16698791
|
Song L |
A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol. |
2006 |
Appl. Biochem. Biotechnol. |
pmid:16484724
|