Nerolidol

Nerolidol is a lipid of Prenol Lipids (PR) class. Nerolidol is associated with abnormalities such as Hyperostosis, Diffuse Idiopathic Skeletal, Corn of toe, Infection, Leishmaniasis and Leishmaniasis, Cutaneous. The involved functions are known as Protein Biosynthesis, Anabolism, Signal, volatile substances and terpene biosynthetic process. Nerolidol often locates in Protoplasm, Plastids, Cytoplasmic matrix, Body tissue and Mitochondria. The associated genes with Nerolidol are Genome, Genes, Plant, Homologous Gene, Recombinant Proteins and monoterpene synthase. The related lipids are Pinene, prenol and Sterols.

Cross Reference

Introduction

To understand associated biological information of Nerolidol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Nerolidol?

Nerolidol is suspected in Plasmodium falciparum infection, Infection, Corn of toe, Leishmaniasis, Leishmaniasis, Cutaneous, Exanthema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Nerolidol

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Dermatomycoses D003881 17 associated lipids
Leishmaniasis D007896 19 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Nerolidol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Nerolidol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Nerolidol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Nerolidol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Nerolidol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Nerolidol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Nerolidol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Nerolidol

Download all related citations
Per page 10 20 50 100 | Total 123
Authors Title Published Journal PubMed Link
Riasat M et al. The constituents of essential oil in leaves of Karaj accession of Trigonella foenum graecum. 2017 Nat. Prod. Res. pmid:28278666
Špičáková A et al. Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions. 2017 Molecules pmid:28338641
Ambrož M et al. The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines. 2017 Molecules pmid:28632185
Goel RK et al. Assessment of anxiolytic effect of nerolidol in mice. 2016 Jul-Aug Indian J Pharmacol pmid:27756960
Utsumi S et al. Effect of Nerolidol and/or Levulinic Acid on the Thermotropic Behavior of Lipid Lamellar Structures in the Stratum Corneum. 2016 Chem. Pharm. Bull. pmid:27904078
Markovic D et al. Plant Responses to Brief Touching: A Mechanism for Early Neighbour Detection? 2016 PLoS ONE pmid:27828995
Javed H et al. Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone. 2016 BMC Neurosci pmid:27549180
Richter A et al. Characterization of Biosynthetic Pathways for the Production of the Volatile Homoterpenes DMNT and TMTT in Zea mays. 2016 Plant Cell pmid:27662898
Chan WK et al. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. 2016 Molecules pmid:27136520
Saito AY et al. Quantification of nerolidol in mouse plasma using gas chromatography-mass spectrometry. 2015 J Pharm Biomed Anal pmid:25880240
da Silva MF et al. In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway. 2015 Antimicrob. Agents Chemother. pmid:26055383
Vucetic A et al. Volatile interaction between undamaged plants affects tritrophic interactions through changed plant volatile emission. 2014 Plant Signal Behav pmid:25763628
Paudel P et al. Volatile analysis and antimicrobial screening of the parasitic plant Cuscuta reflexa Roxb. from Nepal. 2014 Nat. Prod. Res. pmid:24116676
Trung HD et al. Terpene constituents of the leaves of five Vietnamese species of Clausena (Rutaceae). 2014 Nat. Prod. Res. pmid:24617735
Camargos HS et al. Terpenes increase the lipid dynamics in the Leishmania plasma membrane at concentrations similar to their IC50 values. 2014 PLoS ONE pmid:25101672
Baer P et al. Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism. 2014 Chembiochem pmid:24399794
Curvelo JA et al. A novel nerolidol-rich essential oil from Piper claussenianum modulates Candida albicans biofilm. 2014 J. Med. Microbiol. pmid:24523158
BektaÅŸ A et al. Design and evaluation of polysaccharide-based transdermal films for the controlled delivery of nifedipine. 2014 Chem. Pharm. Bull. pmid:24492584
Ma C et al. Determination of nerolidol in teas using headspace solid phase microextraction-gas chromatography. 2014 Food Chem pmid:24444938
Le Thanh C and Chauhan KR Simple and short synthesis of trans-(R)-nerolidol, a pheromone component of fruit spotting bug. 2014 Nat Prod Commun pmid:24689198
Valente PP et al. In vitro acaricidal efficacy of plant extracts from Brazilian flora and isolated substances against Rhipicephalus microplus (Acari: Ixodidae). 2014 Parasitol. Res. pmid:24221889
Silva MP et al. Antischistosomal activity of the terpene nerolidol. 2014 Molecules pmid:24662089
Zhu BQ et al. Identification of a plastid-localized bifunctional nerolidol/linalool synthase in relation to linalool biosynthesis in young grape berries. 2014 Int J Mol Sci pmid:25470020
Erdal MS et al. Impacts of chemical enhancers on skin permeation and deposition of terbinafine. 2014 Pharm Dev Technol pmid:23841559
Dorđević A et al. The case of Hypericum rochelii Griseb. & Schenk and Hypericum umbellatum A. Kern. essential oils: chemical composition and antimicrobial activity. 2013 J Pharm Biomed Anal pmid:23416368
Houshyani B et al. Three-step pathway engineering results in more incidence rate and higher emission of nerolidol and improved attraction of Diadegma semiclausum. 2013 Metab. Eng. pmid:23154132
Sakhanokho HF et al. Chemical composition, antifungal and insecticidal activities of Hedychium essential oils. 2013 Molecules pmid:23579997
Sperotto AR et al. Cytotoxic mechanism of Piper gaudichaudianum Kunth essential oil and its major compound nerolidol. 2013 Food Chem. Toxicol. pmid:23523831
Nogueira Neto JD et al. Antioxidant effects of nerolidol in mice hippocampus after open field test. 2013 Neurochem. Res. pmid:23765368
Triana J et al. A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands. 2013 Phytochemistry pmid:23714725
Wang SY et al. Specific involvement of two amino acid residues in cis-nerolidol binding to odorant-binding protein 5 AlinOBP5 in the alfalfa plant bug, Adelphocoris lineolatus (Goeze). 2013 Insect Mol. Biol. pmid:23294484
Ferreira FM et al. Nerolidol effects on mitochondrial and cellular energetics. 2012 Toxicol In Vitro pmid:22138475
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Chen F et al. Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo. 2012 Fitoterapia pmid:22565145
Cristofari G et al. Chemical diversity of essential oils from Asteriscus graveolens (Forssk.) less.: identification of cis-8-Acetoxychrysanthenyl acetate as a new natural component. 2012 Chem. Biodivers. pmid:22492491
Di Campli E et al. Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs. 2012 Parasitol. Res. pmid:22847279
Martin DM et al. Biosynthesis of wine aroma: transcript profiles of hydroxymethylbutenyl diphosphate reductase, geranyl diphosphate synthase, and linalool/nerolidol synthase parallel monoterpenol glycoside accumulation in Gewürztraminer grapes. 2012 Planta pmid:22824963
Masoudi S et al. Volatile oil constituents of different parts of Artemisia chamaemelifolia and the composition and antibacterial activity of the aerial parts of A. turcomanica from Iran. 2012 Nat Prod Commun pmid:23285821
Ramos CS et al. Metabolism by grasshoppers of volatile chemical constituents from Mangifera indica and Solanum paniculatum leaves. 2012 J. Insect Physiol. pmid:23108151
Suckling DM et al. Volatiles from apple trees infested with light brown apple moth larvae attract the parasitoid Dolichogenidia tasmanica. 2012 J. Agric. Food Chem. pmid:22950817
Steyer D et al. QTL mapping of the production of wine aroma compounds by yeast. 2012 BMC Genomics pmid:23110365
Gonçalves O et al. Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. 2011 Mutat. Res. pmid:21453784
Navarro-Moll MC et al. In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I. 2011 Exp. Parasitol. pmid:20932829
Pículo F et al. In vivo genotoxicity assessment of nerolidol. 2011 J Appl Toxicol pmid:21089164
Tamogami S et al. Conversion of airborne nerolidol to DMNT emission requires additional signals in Achyranthes bidentata. 2011 FEBS Lett. pmid:21510937
Kiem PV et al. Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells. 2011 Bioorg. Med. Chem. Lett. pmid:22071304
Nakano C et al. Identification and characterization of the linalool/nerolidol synthase from Streptomyces clavuligerus. 2011 Chembiochem pmid:21910204
Yang K et al. Toxicity of Rhododendron anthopogonoides essential oil and its constituent compounds towards Sitophilus zeamais. 2011 Molecules pmid:22143541
Song WF et al. [Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction]. 2011 Zhong Yao Cai pmid:22506398
Mabrouk S et al. Chemical composition of essential oils from leaves, stems, flower heads and roots of Conyza bonariensis L. from Tunisia. 2011 Nat. Prod. Res. pmid:21240765
Inui T et al. Sesquiterpenes from Oplopanax horridus. 2010 J. Nat. Prod. pmid:20218656
Padovan A et al. The molecular basis of host plant selection in Melaleuca quinquenervia by a successful biological control agent. 2010 Phytochemistry pmid:20554297
AbouLaila M et al. Inhibitory effect of terpene nerolidol on the growth of Babesia parasites. 2010 Parasitol. Int. pmid:20178862
McGinty D et al. Addendum to Fragrance material review on Nerolidol (isomer unspecified). 2010 Food Chem. Toxicol. pmid:20141875
Okyar A et al. The effect of terpenes on percutaneous absorption of tiaprofenic acid gel. 2010 Arch. Pharm. Res. pmid:21116781
Park YJ et al. Effects of immunotoxic activity of the major essential oil of Angelica purpuraefolia Chung against Aedes aegypti L. 2010 Immunopharmacol Immunotoxicol pmid:20163192
Park MJ et al. Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. 2009 Fitoterapia pmid:19345255
SenyiÄŸit T et al. Different approaches for improving skin accumulation of topical corticosteroids. 2009 Int J Pharm pmid:19635541
Lu Q et al. [Simultaneous determination of water-soluble components and nerolidol in xiangdan injection by high performance liquid chromatography with column switching]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19260309
Nagegowda DA et al. Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowers. 2008 Plant J. pmid:18363779
Lapczynski A et al. Fragrance material review on cis-nerolidol. 2008 Food Chem. Toxicol. pmid:18640201
Lapczynski A et al. Fragrance material review on nerolidol (isomer unspecified). 2008 Food Chem. Toxicol. pmid:18640205
Klopell FC et al. Nerolidol, an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae). 2007 Jul-Aug Z. Naturforsch., C, J. Biosci. pmid:17913068
Nokhodchi A et al. The effect of terpene concentrations on the skin penetration of diclofenac sodium. 2007 Int J Pharm pmid:17174049
Sylvestre M et al. Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) Coulter. 2007 Phytother Res pmid:17326040
Lee SJ et al. Antifungal effect of eugenol and nerolidol against Microsporum gypseum in a guinea pig model. 2007 Biol. Pharm. Bull. pmid:17202684
Hernández I et al. Expression of plant flavor genes in Lactococcus lactis. 2007 Appl. Environ. Microbiol. pmid:17209074
Hampel D et al. Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. 2006 J. Agric. Food Chem. pmid:16478276
Kappers IF et al. Genetic engineering of terpenoid metabolism attracts bodyguards to Arabidopsis. 2005 Science pmid:16179482
Uyanik M et al. Biomimetic synthesis of acid-sensitive (-)-caparrapi oxide and (+)-8-epicaparrapi oxide induced by artificial cyclases. 2005 Org. Lett. pmid:15816762
Arruda DC et al. Antileishmanial activity of the terpene nerolidol. 2005 Antimicrob. Agents Chemother. pmid:15855481
Krishnaiah YS et al. Bioavailability of nerodilol-based transdermal therapeutic system of nicorandil in human volunteers. 2005 J Control Release pmid:15993975
Tonhosolo R et al. Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum. 2005 Biochem. J. pmid:15984931
Pennisi E Plant science. New gene boosts plant's defenses against pests. 2005 Science pmid:16179441
Hu M et al. [Determination of nerolidol in volatile oil of Dalbergia odorifera by GC]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16124604
Hrdlicka PJ et al. Characterization of nerolidol biotransformation based on indirect on-line estimation of biomass concentration and physiological state in batch cultures of Aspergillus niger. 2004 Jan-Feb Biotechnol. Prog. pmid:14763865
Raal A et al. Content and composition of the essential oil of Thymus serpyllum L. growing wild in Estonia. 2004 Medicina (Kaunas) pmid:15300002
Carter-Franklin JN and Butler A Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products. 2004 J. Am. Chem. Soc. pmid:15548002
Aharoni A et al. Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species. 2004 Plant Cell pmid:15522848
Inoue Y et al. The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. 2004 FEMS Microbiol. Lett. pmid:15321680
Kant MR et al. Differential timing of spider mite-induced direct and indirect defenses in tomato plants. 2004 Plant Physiol. pmid:15122016
Aharoni A et al. Terpenoid metabolism in wild-type and transgenic Arabidopsis plants. 2003 Plant Cell pmid:14630967
Walsh SE et al. Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria. 2003 J. Appl. Microbiol. pmid:12534815
Brehm-Stecher BF and Johnson EA Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. 2003 Antimicrob. Agents Chemother. pmid:14506058
de Macedo CS et al. Characterization of the isoprenoid chain of coenzyme Q in Plasmodium falciparum. 2002 FEMS Microbiol. Lett. pmid:11886744
Schnee C et al. The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. 2002 Plant Physiol. pmid:12481088
Goodwin TE et al. African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol. 2002 J. Nat. Prod. pmid:12350155
Degenhardt J and Gershenzon J Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis. 2000 Planta pmid:10805454
Bouwmeester HJ et al. Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis. 1999 Plant Physiol. pmid:10482672
Chinou IB et al. Chemical and biological studies on two Helichrysum species of Greek origin. 1996 Planta Med. pmid:8792676
Madyastha KM and Gururaja TL A new pathway for the degradation of a sesquiterpene alcohol, nerolidol by Alcaligenes eutrophus. 1993 Biochem. Biophys. Res. Commun. pmid:8503916
Wattenberg LW Inhibition of azoxymethane-induced neoplasia of the large bowel by 3-hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene (nerolidol). 1991 Carcinogenesis pmid:1988176
Nishino T et al. Enzymatic formation of nerolidol in cell-free extract of Rhodotorula glutinis. 1982 J. Biochem. pmid:6891702
NAVES YR [Not Available]. 1947 Helv. Chim. Acta pmid:20294155
pmid:
pmid:27939849
pmid:28704964
pmid:28450026
pmid:28093813
pmid:27923567