Nerolidol

Nerolidol is a lipid of Prenol Lipids (PR) class. Nerolidol is associated with abnormalities such as Hyperostosis, Diffuse Idiopathic Skeletal, Corn of toe, Infection, Leishmaniasis and Leishmaniasis, Cutaneous. The involved functions are known as Protein Biosynthesis, Anabolism, Signal, volatile substances and terpene biosynthetic process. Nerolidol often locates in Protoplasm, Plastids, Cytoplasmic matrix, Body tissue and Mitochondria. The associated genes with Nerolidol are Genome, Genes, Plant, Homologous Gene, Recombinant Proteins and monoterpene synthase. The related lipids are Pinene, prenol and Sterols.

Cross Reference

Introduction

To understand associated biological information of Nerolidol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Nerolidol?

Nerolidol is suspected in Plasmodium falciparum infection, Infection, Corn of toe, Leishmaniasis, Leishmaniasis, Cutaneous, Exanthema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Nerolidol

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Dermatomycoses D003881 17 associated lipids
Leishmaniasis D007896 19 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Nerolidol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Nerolidol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Nerolidol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Nerolidol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Nerolidol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Nerolidol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Nerolidol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Nerolidol

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Authors Title Published Journal PubMed Link
Inoue Y et al. The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. 2004 FEMS Microbiol. Lett. pmid:15321680
Park MJ et al. Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. 2009 Fitoterapia pmid:19345255
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Lapczynski A et al. Fragrance material review on nerolidol (isomer unspecified). 2008 Food Chem. Toxicol. pmid:18640205
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Wang SY et al. Specific involvement of two amino acid residues in cis-nerolidol binding to odorant-binding protein 5 AlinOBP5 in the alfalfa plant bug, Adelphocoris lineolatus (Goeze). 2013 Insect Mol. Biol. pmid:23294484
Zhu BQ et al. Identification of a plastid-localized bifunctional nerolidol/linalool synthase in relation to linalool biosynthesis in young grape berries. 2014 Int J Mol Sci pmid:25470020
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Saito AY et al. Quantification of nerolidol in mouse plasma using gas chromatography-mass spectrometry. 2015 J Pharm Biomed Anal pmid:25880240
Hampel D et al. Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. 2006 J. Agric. Food Chem. pmid:16478276
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Nishino T et al. Enzymatic formation of nerolidol in cell-free extract of Rhodotorula glutinis. 1982 J. Biochem. pmid:6891702
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Ramos CS et al. Metabolism by grasshoppers of volatile chemical constituents from Mangifera indica and Solanum paniculatum leaves. 2012 J. Insect Physiol. pmid:23108151
Curvelo JA et al. A novel nerolidol-rich essential oil from Piper claussenianum modulates Candida albicans biofilm. 2014 J. Med. Microbiol. pmid:24523158
Inui T et al. Sesquiterpenes from Oplopanax horridus. 2010 J. Nat. Prod. pmid:20218656
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Raal A et al. Content and composition of the essential oil of Thymus serpyllum L. growing wild in Estonia. 2004 Medicina (Kaunas) pmid:15300002
Houshyani B et al. Three-step pathway engineering results in more incidence rate and higher emission of nerolidol and improved attraction of Diadegma semiclausum. 2013 Metab. Eng. pmid:23154132
Yang K et al. Toxicity of Rhododendron anthopogonoides essential oil and its constituent compounds towards Sitophilus zeamais. 2011 Molecules pmid:22143541
Sakhanokho HF et al. Chemical composition, antifungal and insecticidal activities of Hedychium essential oils. 2013 Molecules pmid:23579997
Silva MP et al. Antischistosomal activity of the terpene nerolidol. 2014 Molecules pmid:24662089
Špičáková A et al. Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions. 2017 Molecules pmid:28338641
Ambrož M et al. The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines. 2017 Molecules pmid:28632185
Chan WK et al. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. 2016 Molecules pmid:27136520
Gonçalves O et al. Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. 2011 Mutat. Res. pmid:21453784
Masoudi S et al. Volatile oil constituents of different parts of Artemisia chamaemelifolia and the composition and antibacterial activity of the aerial parts of A. turcomanica from Iran. 2012 Nat Prod Commun pmid:23285821
Le Thanh C and Chauhan KR Simple and short synthesis of trans-(R)-nerolidol, a pheromone component of fruit spotting bug. 2014 Nat Prod Commun pmid:24689198
Riasat M et al. The constituents of essential oil in leaves of Karaj accession of Trigonella foenum graecum. 2017 Nat. Prod. Res. pmid:28278666
Paudel P et al. Volatile analysis and antimicrobial screening of the parasitic plant Cuscuta reflexa Roxb. from Nepal. 2014 Nat. Prod. Res. pmid:24116676
Trung HD et al. Terpene constituents of the leaves of five Vietnamese species of Clausena (Rutaceae). 2014 Nat. Prod. Res. pmid:24617735
Mabrouk S et al. Chemical composition of essential oils from leaves, stems, flower heads and roots of Conyza bonariensis L. from Tunisia. 2011 Nat. Prod. Res. pmid:21240765
Nogueira Neto JD et al. Antioxidant effects of nerolidol in mice hippocampus after open field test. 2013 Neurochem. Res. pmid:23765368
Uyanik M et al. Biomimetic synthesis of acid-sensitive (-)-caparrapi oxide and (+)-8-epicaparrapi oxide induced by artificial cyclases. 2005 Org. Lett. pmid:15816762
AbouLaila M et al. Inhibitory effect of terpene nerolidol on the growth of Babesia parasites. 2010 Parasitol. Int. pmid:20178862
Di Campli E et al. Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs. 2012 Parasitol. Res. pmid:22847279
Valente PP et al. In vitro acaricidal efficacy of plant extracts from Brazilian flora and isolated substances against Rhipicephalus microplus (Acari: Ixodidae). 2014 Parasitol. Res. pmid:24221889
Erdal MS et al. Impacts of chemical enhancers on skin permeation and deposition of terbinafine. 2014 Pharm Dev Technol pmid:23841559