(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

Download all related citations
Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Bradfute DL et al. Squalene synthase-deficient mutant of Chinese hamster ovary cells. 1992 J. Biol. Chem. pmid:1526971
Keller RK et al. Studies on the regulation of glycoprotein biosynthesis. An investigation of the rate-limiting steps of dolichyl phosphate biosynthesis. 1979 J. Biol. Chem. pmid:489612
Bostedor RG et al. Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. 1997 J. Biol. Chem. pmid:9083051
Koeppe JK et al. A specific photoaffinity label for hemolymph and ovarian juvenile hormone-binding proteins in Leucophaea maderae. 1984 J. Biol. Chem. pmid:6699014
Christenson JG et al. Enzymatic synthesis of the antigen carrier lipid. 1969 J. Biol. Chem. pmid:4311788
Popják G et al. Biosynthesis and structure of a new intermediate between farnesyl pyrophosphate and squalene. 1969 J. Biol. Chem. pmid:4388617
Heinstein PF et al. Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. 1970 J. Biol. Chem. pmid:4318479
Roullet JB et al. Farnesol inhibits L-type Ca2+ channels in vascular smooth muscle cells. 1997 J. Biol. Chem. pmid:9405427
Dorsey JK and Porter JW The inhibition of mevalonic kinase by geranyl and farnesyl pyrophosphates. 1968 J. Biol. Chem. pmid:4300840
Carel K et al. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. 1996 J. Biol. Chem. pmid:8940037
McGuire TF et al. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. 1996 J. Biol. Chem. pmid:8910319
Zhang L et al. Isolation and characterization of a prenylcysteine lyase from bovine brain. 1997 J. Biol. Chem. pmid:9287348
Gavey KL and Scallen TJ Nonparticipation of 105,000 x g liver supernatant or sterol carrier protein in the enzymatic conversion of farnesyl pyrophosphate to squalene by rat liver microsomes. 1978 J. Biol. Chem. pmid:209043
Miquel K et al. Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. 1998 J. Biol. Chem. pmid:9748300
Agnew WS and Popják G Squalene synthetase. Stoichiometry and kinetics of presqualene pyrophosphate and squalene synthesis by yeast microsomes. 1978 J. Biol. Chem. pmid:26684
Rosado JA and Sage SO Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. 2001 J. Biol. Chem. pmid:11278479
Wright MM et al. Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. 2001 J. Biol. Chem. pmid:11306571
Daily D et al. Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways. 2001 J. Biol. Chem. pmid:11290748
Epstein WW and Rilling HC Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. 1970 J. Biol. Chem. pmid:4318477
Golczak M et al. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. 2008 J. Biol. Chem. pmid:18195010
Muscio F et al. Prequalene pyrophosphate. A normal intermediate in squalene biosynthesis. 1974 J. Biol. Chem. pmid:4152099
Yang W et al. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. 2000 J. Biol. Chem. pmid:10617635
Hanley K et al. Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. 2000 J. Biol. Chem. pmid:10753967
Tschantz WR et al. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. 2001 J. Biol. Chem. pmid:11078725
Sever N et al. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. 2003 J. Biol. Chem. pmid:14563840
Fogelman AM et al. Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia. 1975 J. Biol. Chem. pmid:1116997
de Ropp JS and Troy FA 2H NMR investigation of the organization and dynamics of polyisoprenols in membranes. 1985 J. Biol. Chem. pmid:4066690
Chen CK et al. Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. 2010 J. Biol. Inorg. Chem. pmid:19727859
Chen CK et al. The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity. 2008 J. Biol. Inorg. Chem. pmid:18392864
Granshaw T et al. Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. 2003 J. Biol. Rhythms pmid:12932081
Muramatsu M et al. Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols. 2008 J. Biosci. Bioeng. pmid:18930003
Muramatsu M et al. Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. 2009 J. Biosci. Bioeng. pmid:19577192
Cho SW et al. Positive regulation of osteogenesis by bile acid through FXR. 2013 J. Bone Miner. Res. pmid:23609136
Shohami E et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. 2003 J. Cereb. Blood Flow Metab. pmid:12796721
Yang Z et al. Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella. 2004 J. Chem. Ecol. pmid:15139312
Shimomura K et al. 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic). 2010 J. Chem. Ecol. pmid:20607368
Shimomura K et al. Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis. 2008 J. Chem. Ecol. pmid:18351422
Xiao Y et al. A two-component female-produced pheromone of the spider Pholcus beijingensis. 2009 J. Chem. Ecol. pmid:19579045
Zhao M et al. Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18534927
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
Roullet JB et al. Farnesyl analogues inhibit vasoconstriction in animal and human arteries. 1996 J. Clin. Invest. pmid:8636420
Koo H et al. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. 2005 J. Dent. Res. pmid:16246933
Katsuyama M et al. A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. 2005 J. Dermatol. Sci. pmid:15927813
Katsuyama M et al. A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. 2005 J. Dermatol. Sci. pmid:15927814
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Lin HP et al. Localization of isoprenylated antigen of hepatitis delta virus by anti-farnesyl antibodies. 1999 J. Gen. Virol. pmid:9934689
Reif S et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats. 1999 J. Hepatol. pmid:10604579
Reif S et al. Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. 2004 J. Hepatol. pmid:15288472
Roullet JB et al. Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. 1997 J. Hypertens. pmid:9488229
Spielman A and Skaff V Inhibition of metamorphosis and of ecdysis in mosquitoes. 1967 J. Insect Physiol. pmid:6043875

Table of Content