(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Fibrosis D005355 23 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Glioblastoma D005909 27 associated lipids
Nephritis D009393 19 associated lipids
HIV Infections D015658 20 associated lipids
Neurilemmoma D009442 10 associated lipids
Insulin Resistance D007333 99 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Nerve Sheath Neoplasms D018317 4 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Weber K et al. The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species. 2010 Yeast pmid:20641010
Uppuluri P et al. Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue. 2007 Yeast pmid:17583896
Saidi S et al. In vitro synergistic effect of farnesol and human gingival cells against Candida albicans. 2006 Yeast pmid:16845684
Cordeiro Rde A et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. 2012 Vet. Microbiol. pmid:22580194
Teodoro JS et al. Hepatic FXR: key regulator of whole-body energy metabolism. 2011 Trends Endocrinol. Metab. pmid:21862343
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Flint OP et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Toxicol. Appl. Pharmacol. pmid:9221828
Yang SP and Raner GM Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. 2005 Toxicol. Appl. Pharmacol. pmid:15629189
Winn LM and Wells PG Evidence for Ras-dependent signal transduction in phenytoin teratogenicity. 2002 Toxicol. Appl. Pharmacol. pmid:12460742
Mussoni L et al. Fluvastatin inhibits basal and stimulated plasminogen activator inhibitor 1, but induces tissue type plasminogen activator in cultured human endothelial cells. 2000 Thromb. Haemost. pmid:10928471
Zhang X et al. Nanomicellar carriers for targeted delivery of anticancer agents. 2014 Ther Deliv pmid:24341817
Graebe JE Isoprenoid biosynthesis in a cell-free system from pea shoots. 1967 Science pmid:4381746
Pei ZM et al. Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. 1998 Science pmid:9765153
Ilayaraja R et al. Evaluating the binding efficiency of pheromone binding protein with its natural ligand using molecular docking and fluorescence analysis. 2014 Sci Rep pmid:24903953
Jahangir T et al. Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice. 2005 Redox Rep. pmid:16438802
Blum R et al. Inhibitors of chronically active ras: potential for treatment of human malignancies. 2008 Recent Pat Anticancer Drug Discov pmid:18289122
Banfi C et al. Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme. 2009 Proteomics pmid:19253276
McPherson RA et al. The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. 2004 Prostate pmid:14968433
Cornforth J Symmetry of squalene epoxidation in vivo. 1977 Proc. R. Soc. Lond., B, Biol. Sci. pmid:22855
Donninger C and Popják G Studies on the biosynthesis of cholesterol. 18. The stereospecificity of mevaldate reductase and the biosynthesis of asymmetrically labelled farnesyl pyrophosphate. 1966 Proc. R. Soc. Lond., B, Biol. Sci. pmid:4379290
Lutz RJ et al. Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1557405
Ma YT and Rando RR A microsomal endoprotease that specifically cleaves isoprenylated peptides. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1631119
Kato K et al. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1631135
Kotti T et al. Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18685105
Jackson JH et al. Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2183224
Peleg AY et al. Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18794525
Mayoral JG et al. NADP+-dependent farnesol dehydrogenase, a corpora allata enzyme involved in juvenile hormone synthesis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19940247
Caldwell GA et al. Consequences of altered isoprenylation targets on a-factor export and bioactivity. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8108401
Laezza C et al. v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9811854
Lu Y et al. Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24449897
Fisher JE et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874784
Parmryd I et al. Protein prenylation in spinach chloroplasts. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10468564
Lai RK et al. The gamma subunit of transducin is farnesylated. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2217200
Casey PJ et al. p21ras is modified by a farnesyl isoprenoid. 1989 Proc. Natl. Acad. Sci. U.S.A. pmid:2682646
Stone KJ and Strominger JL Inhibition of sterol biosynthesis by bacitracin. 1972 Proc. Natl. Acad. Sci. U.S.A. pmid:4338587
Jautelat M et al. Natural-abundance 13C nuclear magnetic resonance spectra of terpenes and carotenes. 1970 Proc. Natl. Acad. Sci. U.S.A. pmid:5263764
Thai L et al. Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10557276
Jansen B et al. Novel Ras antagonist blocks human melanoma growth. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570191
Law JH et al. Synthesis of a material with high juvenile hormone activity. 1966 Proc. Natl. Acad. Sci. U.S.A. pmid:5221241
Madhani HD Quorum sensing in fungi: Q&A. 2011 PLoS Pathog. pmid:22046125
Lopez-Medina E et al. Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. 2015 PLoS Pathog. pmid:26313907
Nevo Y et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. 2011 PLoS ONE pmid:21445359
Chen M et al. Use of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasion. 2014 PLoS ONE pmid:24587105
Zhu J et al. Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. 2011 PLoS ONE pmid:22205973
Zhang L et al. Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. 2011 PLoS ONE pmid:22174935
Chang W et al. Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. 2012 PLoS ONE pmid:22848547
Fu MS et al. Functional characterization of the small heat shock protein Hsp12p from Candida albicans. 2012 PLoS ONE pmid:22880130
Zhu J et al. Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective. 2016 PLoS ONE pmid:26959814
Xu H et al. Glucanase induces filamentation of the fungal pathogen Candida albicans. 2013 PLoS ONE pmid:23737947
Nyati P et al. Farnesyl phosphatase, a Corpora allata enzyme involved in juvenile hormone biosynthesis in Aedes aegypti. 2013 PLoS ONE pmid:23940797
Schokoroy S et al. Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death. 2013 PLoS ONE pmid:24086490
Mologni L et al. Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. 2012 PLoS ONE pmid:23227266
Mor A et al. Ras inhibition induces insulin sensitivity and glucose uptake. 2011 PLoS ONE pmid:21738773
Wu L et al. Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives. 2017 PLoS ONE pmid:28182780
Schmukler E et al. Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. 2017 PLoS ONE pmid:28151959
Jung SI et al. Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades. 2016 PLoS ONE pmid:26848577
Seman-Kamarulzaman AF et al. Novel NAD+-Farnesal Dehydrogenase from Polygonum minus Leaves. Purification and Characterization of Enzyme in Juvenile Hormone III Biosynthetic Pathway in Plant. 2016 PLoS ONE pmid:27560927
Krause J et al. Prostaglandin E2 from Candida albicans Stimulates the Growth of Staphylococcus aureus in Mixed Biofilms. 2015 PLoS ONE pmid:26262843
Mogen AB et al. Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms. 2015 PLoS ONE pmid:26222384
Strube-Bloss MF et al. Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris. 2015 PLoS ONE pmid:26340263
Shin KO et al. Terpene alcohols inhibit de novo sphingolipid biosynthesis. 2012 Planta Med. pmid:22274813
Fitzpatrick AH et al. Roles for farnesol and ABA in Arabidopsis flower development. 2011 Plant Signal Behav pmid:21758018
Bhandari J et al. Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. 2010 Plant Physiol. pmid:20807998
Schnee C et al. The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. 2002 Plant Physiol. pmid:12481088
Hemmerlin A and Bach TJ Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in tobacco cv bright yellow-2 cells. 2000 Plant Physiol. pmid:10938345
Fitzpatrick AH et al. Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. 2011 Plant J. pmid:21395888
Crowell DN et al. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. 2007 Plant J. pmid:17425716
Nah J et al. Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation. 2001 Plant Cell Physiol. pmid:11522913
Cheng AX et al. The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes. 2007 Phytochemistry pmid:17524436
Kuete V and Efferth T Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol. 2013 Pharmazie pmid:23923645
Cetin A et al. Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells. 2007 Pharmacology pmid:17135774
Tojo K et al. Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. 1994 Pharm. Res. pmid:8008705
Zhang W et al. Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission. 2015 Pharm. Res. pmid:25794967
Tóth M et al. Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. 2003 Pest Manag. Sci. pmid:12701702
Teal PE Effects of allatotropin and allatostatin on in vitro production of juvenile hormones by the corpora allata of virgin females of the moths of Heliothis virescens and Manduca sexta. 2002 Peptides pmid:11897385
Pammi M et al. Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. 2011 Pediatr. Res. pmid:21857375
Marcuzzi A et al. Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. 2008 Pediatr. Res. pmid:18391837
Toró A et al. Transannular Diels-Alder studies on the asymmetric total synthesis of chatancin: the pyranophane approach. 2000 Org. Lett. pmid:10964353
Yu JS et al. Synthesis of farnesol isomers via a modified Wittig procedure. 2005 Org. Lett. pmid:16235893
Rudi A et al. Likonides A and B: new ansa farnesyl quinols from the marine sponge Hyatella sp. 2004 Org. Lett. pmid:15496087
Jin Y and Qiu FG A convergent stereocontrolled total synthesis of (-)-terpestacin. 2012 Org. Biomol. Chem. pmid:22710980
Koo H et al. Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. 2002 Oral Microbiol. Immunol. pmid:12485324
Aizman E et al. Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes. 2012 Oncotarget pmid:22323550
Mashiach-Farkash E et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. 2012 Oncotarget pmid:22776759
Schmukler E et al. Ras inhibition enhances autophagy, which partially protects cells from death. 2013 Oncotarget pmid:23370967
Barkan B et al. Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis. 2013 Oncotarget pmid:23530091
Faigenbaum R et al. Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. 2013 Oncotarget pmid:23530112
Cheng HL et al. Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways. 2016 Oncotarget pmid:26848867
Hameiri-Grossman M et al. The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth. 2015 Oncotarget pmid:26393682
Goldshmit Y et al. Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma. 2014 Oncotarget pmid:25261371
Schmukler E et al. Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death. 2014 Oncotarget pmid:24368422
Hanker AB et al. Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. 2010 Oncogene pmid:19838215
Weisz B et al. A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. 1999 Oncogene pmid:10353601
Ghosh PM et al. Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. 1999 Oncogene pmid:10435593
Shack S et al. Activation of the cholesterol pathway and Ras maturation in response to stress. 1999 Oncogene pmid:10557091
Jones S et al. β-ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. 2013 Nutr Cancer pmid:23659452
Cho T et al. [Farnesol as a quorum-sensing molecule in Candida albicans]. 2008 Nihon Ishinkin Gakkai Zasshi pmid:19001754
Cho T et al. Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium. 2007 Nihon Ishinkin Gakkai Zasshi pmid:17975531
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Binda C et al. Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design. 2006 Neurology pmid:17030739

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