(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Fibrosis D005355 23 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Glioblastoma D005909 27 associated lipids
Nephritis D009393 19 associated lipids
HIV Infections D015658 20 associated lipids
Neurilemmoma D009442 10 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Shirtliff ME et al. Farnesol-induced apoptosis in Candida albicans. 2009 Antimicrob. Agents Chemother. pmid:19364863
Chen F et al. Tooth-binding micelles for dental caries prevention. 2009 Antimicrob. Agents Chemother. pmid:19704121
Yu LH et al. Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. 2012 Antimicrob. Agents Chemother. pmid:22106223
Brilhante RS et al. Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei. 2012 Antimicrob. Agents Chemother. pmid:22290941
Kostoulias X et al. Impact of a Cross-Kingdom Signaling Molecule of Candida albicans on Acinetobacter baumannii Physiology. 2015 Antimicrob. Agents Chemother. pmid:26482299
Rossignol T et al. Transcriptional response of Candida parapsilosis following exposure to farnesol. 2007 Antimicrob. Agents Chemother. pmid:17684006
Hornby JM et al. Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. 2003 Antimicrob. Agents Chemother. pmid:12821501
Cao YY et al. cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. 2005 Antimicrob. Agents Chemother. pmid:15673737
Brehm-Stecher BF and Johnson EA Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. 2003 Antimicrob. Agents Chemother. pmid:14506058
Pfister C et al. Detection and quantification of farnesol-induced apoptosis in difficult primary cell cultures by TaqMan protein assay. 2013 Apoptosis pmid:23315006
Song L A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol. 2006 Appl. Biochem. Biotechnol. pmid:16484724
Dionigi CP et al. Effects of farnesol and the off-flavor derivative geosmin on Streptomyces tendae. 1991 Appl. Environ. Microbiol. pmid:1785920
Hornby JM et al. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. 2001 Appl. Environ. Microbiol. pmid:11425711
de Salas F et al. Quorum-Sensing Mechanisms Mediated by Farnesol in Ophiostoma piceae: Effect on Secretion of Sterol Esterase. 2015 Appl. Environ. Microbiol. pmid:25888179
Ramage G et al. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. 2002 Appl. Environ. Microbiol. pmid:12406738
Hornby JM et al. Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. 2004 Appl. Environ. Microbiol. pmid:15006753
Mosel DD et al. Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. 2005 Appl. Environ. Microbiol. pmid:16085901
Nickerson KW et al. Quorum sensing in dimorphic fungi: farnesol and beyond. 2006 Appl. Environ. Microbiol. pmid:16751484
Muramatsu M et al. Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms. 2008 Appl. Microbiol. Biotechnol. pmid:18636253
Suzue G et al. Presence of squalene in Staphylococcus. 1968 Arch. Biochem. Biophys. pmid:5650319
Havel CM and Watson JA Isopentenoid synthesis in isolated embryonic Drosophila cells: absolute, basal mevalonate synthesis rate determination. 1992 Arch. Biochem. Biophys. pmid:1567218
Bai M and Prestwich GD Inhibition and activation of porcine squalene epoxidase. 1992 Arch. Biochem. Biophys. pmid:1536566
Saito A and Rilling HC The formation of cyclic sesquiterpenes from farnesyl pyrophosphate by prenyltransferase. 1981 Arch. Biochem. Biophys. pmid:7259201
Vaidya S et al. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. 1998 Arch. Biochem. Biophys. pmid:9647670
Keenan MV and Allen CM Characterization of undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum. 1974 Arch. Biochem. Biophys. pmid:4599964
Dugan RE and Porter JW Hog liver squalene synthetase: the partial purification of the particulate enzyme and kinetic analysis of the reaction. 1972 Arch. Biochem. Biophys. pmid:4403691
Jungalwala FB and Porter JW Biosynthesis of phytoene from isopentenyl and farnesyl pyrophosphates by a partially purified tomato enzyme system. 1967 Arch. Biochem. Biophys. pmid:4293186
Meigs TE and Simoni RD Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. 1997 Arch. Biochem. Biophys. pmid:9281305
Benedict CR et al. Properties of farnesyl pyrophosphate synthetase of pig liver. 1965 Arch. Biochem. Biophys. pmid:4284635
Krishna G et al. Enzymic conversion of farnesyl pyrophosphate to squalene. 1966 Arch. Biochem. Biophys. pmid:4380977
Desrosiers RR and Béliveau R Regulation by GTPgammaS of protein carboxylmethyltransferase activity in kidney brush border membranes. 1998 Arch. Biochem. Biophys. pmid:9514644
Bentinger M et al. Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase. 1998 Arch. Biochem. Biophys. pmid:9606952
Baba T et al. Dehydrodolichyl diphosphate synthetase from rat seminiferous tubules. 1987 Arch. Biochem. Biophys. pmid:3813545
Parmryd I and Dallner G In vivo prenylation of rat proteins: modification of proteins with penta- and hexaprenyl groups. 1999 Arch. Biochem. Biophys. pmid:10190969
Xu L and Simoni RD The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. 2003 Arch. Biochem. Biophys. pmid:12781775
Hemmerlin A et al. Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog. 2006 Arch. Biochem. Biophys. pmid:16307722
Keller RK et al. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Arch. Biochem. Biophys. pmid:8645011
Andres DA et al. Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. 1997 Arch. Biochem. Biophys. pmid:9328291
Aclé D et al. Activity of the corpora allata of adult female Leucophaea maderae: effects of mating and feeding. 1990 Arch. Insect Biochem. Physiol. pmid:2134173
Luft UC et al. Farnesol blocks the L-type Ca2+ channel by targeting the alpha 1C subunit. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10195923
Llorente-Cortés V et al. Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9598832
George J et al. Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14670932
Frenkel J et al. Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. 2002 Arthritis Rheum. pmid:12384940
Corsini A et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. 1993 Atherosclerosis pmid:8216498
Giricz Z et al. Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. 2003 Basic Res. Cardiol. pmid:12955403
Touhara K and Prestwich GD Binding site mapping of a photoaffinity-labeled juvenile hormone binding protein. 1992 Biochem. Biophys. Res. Commun. pmid:1734862
Tanaka H et al. MEKA/phosducin attenuates hydrophobicity of transducin beta gamma subunits without binding to farnesyl moiety. 1996 Biochem. Biophys. Res. Commun. pmid:8687440
Yang L et al. ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. 2011 Biochem. Biophys. Res. Commun. pmid:21621522
Kamiya Y et al. Metabolites of mating pheromone, rhodotorucine A, by a cells of Rhodosporidium toruloides. 1980 Biochem. Biophys. Res. Commun. pmid:7396935
Melnykovych G et al. Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol. 1992 Biochem. Biophys. Res. Commun. pmid:1632790
Keung WM Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism. 1991 Biochem. Biophys. Res. Commun. pmid:1993065
George-Nascimento C et al. Non enzymic formation of nerolidol from farnesyl pyrophosphate in the presence of bivalent cations. 1971 Biochem. Biophys. Res. Commun. pmid:4334520
Kurokawa T et al. Formation of polyprenyl phosphates by a cell-free enzyme of Micrococcus lysodeikticus. 1971 Biochem. Biophys. Res. Commun. pmid:4334524
András IE et al. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. 2012 Biochem. Biophys. Res. Commun. pmid:22490665
Castelli A et al. Effect of hydroxy analogs of coenzyme Q on DPNH- and succin-oxidase activities of yeast mitochondria. 1971 Biochem. Biophys. Res. Commun. pmid:4324835
Rilling HC The effect of sterol carrier protein on squalene synthesis. 1972 Biochem. Biophys. Res. Commun. pmid:4400440
Gana-Weisz M et al. The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation. 1997 Biochem. Biophys. Res. Commun. pmid:9367867
Crick DC et al. Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. 1997 Biochem. Biophys. Res. Commun. pmid:9299388
Van Dessel G et al. Internalisation of short-chain isoprenyl diphosphates by chromaffin cells from bovine adrenal medulla. 1997 Biochem. Biophys. Res. Commun. pmid:9299441
Westfall D et al. Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. 1997 Biochem. Biophys. Res. Commun. pmid:9015362
Green TR et al. Compartmentation of isopentenyl pyophosphate isomerase and prenyl transferase in developing castor bean endosperm. 1975 Biochem. Biophys. Res. Commun. pmid:167761
Inoue H et al. Formation of farnesal and 3-hydroxy-2,3-dihydrofarnesal from farnesol by protoplasts of Botryococcus braunii. 1993 Biochem. Biophys. Res. Commun. pmid:8250896
Akopyan TN et al. Cleavage of farnesylated COOH-terminal heptapeptide of mouse N-ras by brain microsomal membranes: evidence for a carboxypeptidase which specifically removes the COOH-terminal methionine. 1992 Biochem. Biophys. Res. Commun. pmid:1417809
Sakane C et al. Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. 2014 Biochem. Biophys. Res. Commun. pmid:24406160
Kamiya Y et al. Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides. 1978 Biochem. Biophys. Res. Commun. pmid:708426
Inoue H et al. Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. 1994 Biochem. Biophys. Res. Commun. pmid:8179579
Anant JS and Fung BK In vivo farnesylation of rat rhodopsin kinase. 1992 Biochem. Biophys. Res. Commun. pmid:1550556
Mizukami Y et al. Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells. 2001 Biochem. Biophys. Res. Commun. pmid:11594773
Tsuchiya E and Fukui S Binding of rhodotorucine A, a lipopeptidyl mating hormone, to a cells of Rhodosporidium toruloides for induction of sexual differentiation. 1978 Biochem. Biophys. Res. Commun. pmid:743290
Rakhit RD et al. Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury. 2001 Biochem. Biophys. Res. Commun. pmid:11527399
Qureshi AA et al. Squalene synthetase. I. Dissociation and reassociation of enzyme complex. 1972 Biochem. Biophys. Res. Commun. pmid:4341049
Heintz R et al. Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant. 1972 Biochem. Biophys. Res. Commun. pmid:4344813
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Raner GM et al. Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes. 2002 Biochem. Biophys. Res. Commun. pmid:12054554
Krishna G et al. An enzyme-bound intermediate in the conversion of farnesyl pyrophosphate to squalene. 1964 Biochem. Biophys. Res. Commun. pmid:4284347
Crick DC et al. Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. 1995 Biochem. Biophys. Res. Commun. pmid:7794274
Flach J et al. The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. 2000 Biochem. Biophys. Res. Commun. pmid:10733934
Akopyan TN et al. Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15. 1994 Biochem. Biophys. Res. Commun. pmid:8297391
Voziyan PA et al. Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. 1995 Biochem. Biophys. Res. Commun. pmid:7626062
Fukuda S and Pelus LM Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. 2004 Biochem. Biophys. Res. Commun. pmid:15369798
Duncan RE and Archer MC Farnesol induces thyroid hormone receptor (THR) beta1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells. 2006 Biochem. Biophys. Res. Commun. pmid:16540091
Fliesler SJ and Keller RK Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. 1995 Biochem. Biophys. Res. Commun. pmid:7763243
Lagace TA and Ridgway ND Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha). 2005 Biochem. J. pmid:16097951
Popják G et al. Artificial substrates for prenyltransferase. 1969 Biochem. J. pmid:4309597
Etemadi AH et al. Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems. 1969 Biochem. J. pmid:4388240
Gough DP and Hemming FW The characterization and stereochemistry of biosynthesis of dolichols in rat liver. 1970 Biochem. J. pmid:4319540
Flint AP The activity and kinetic properties of mevalonate kinase in superovulated rat ovary. 1970 Biochem. J. pmid:4321929
Walton MJ and Pennock JF Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. 1972 Biochem. J. pmid:4403925
Popják G et al. Synthesis of 10,11-dihydrofarnesyl pyrophosphate from 6,7-dihydrogeranyl pyrophosphate by prenyltransferase. 1969 Biochem. J. pmid:4304159
Pérez-Sala D et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. 1992 Biochem. J. pmid:1622400
Chen AP et al. Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase. 2005 Biochem. J. pmid:15447632
Beedle AS et al. Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol. 1974 Biochem. J. pmid:4140721
Hamilton JA and Cox GB Ubiquinone biosynthesis in Escherichia coli K-12. Accumulation of an octaprenol, farnesylfarnesylgeraniol, by a multiple aromatic auxotroph. 1971 Biochem. J. pmid:4942305
Dietrich A et al. Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. 2003 Biochem. J. pmid:12952523
Tobe SS and Pratt GE The influence of substrate concentrations on the rate of insect juvenile hormone biosynthesis by corpora allata of the desert locust in vitro. 1974 Biochem. J. pmid:4462567
Overton KH and Roberts FM Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata. 1974 Biochem. J. pmid:4468823
Alam SS et al. Prenol phosphates and mannosyltransferases. 1971 Biochem. J. pmid:5116535
Rosado JA and Sage SO Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton. 2000 Biochem. J. pmid:10727417
Voziyan PA et al. Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. 1993 Biochem. J. pmid:8240288
Staines AG et al. Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1. 2004 Biochem. J. pmid:15320866

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