(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Fibrosis D005355 23 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Glioblastoma D005909 27 associated lipids
Nephritis D009393 19 associated lipids
HIV Infections D015658 20 associated lipids
Neurilemmoma D009442 10 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Houten SM et al. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. 2003 Cell. Mol. Life Sci. pmid:12861380
Iguchi T et al. Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. 2003 Cell. Signal. pmid:12742232
Shchepin R et al. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. 2003 Chem. Biol. pmid:12954333
Shchepin R et al. Biologically active fluorescent farnesol analogs. 2005 Chem. Biol. pmid:15975508
Khan R and Sultana S Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. 2011 Chem. Biol. Interact. pmid:21453689
Endo S et al. Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. 2011 Chem. Biol. Interact. pmid:21187079
Qamar W and Sultana S Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention. 2008 Chem. Biol. Interact. pmid:18793622
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Horn TL et al. Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. 2005 Chem. Biol. Interact. pmid:15840382
Bondar OP et al. Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. 1994 Chem. Phys. Lipids pmid:7820904
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Akiyama H et al. Actions of farnesol and xylitol against Staphylococcus aureus. 2002 Chemotherapy pmid:12138327
Luxová A et al. Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. 2004 Chirality pmid:15034905
George J et al. Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. 2002 Circulation pmid:12021230
Badar T et al. Phase I study of S-trans, trans-farnesylthiosalicylic acid (salirasib), a novel oral RAS inhibitor in patients with refractory hematologic malignancies. 2015 Clin Lymphoma Myeloma Leuk pmid:25795639
Gana-Weisz M et al. The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance. 2002 Clin. Cancer Res. pmid:11839677
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Goossens A and Merckx L Allergic contact dermatitis from farnesol in a deodorant. 1997 Contact Derm. pmid:9385513
Frosch PJ et al. Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. 2005 Contact Derm. pmid:15859993
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Hemmer W et al. Axillary dermatitis from farnesol in a deodorant. 2000 Contact Derm. pmid:10727172
Schnuch A et al. Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. 2004 Contact Derm. pmid:15153123
Mor A et al. Immunomodulatory properties of farnesoids: the new steroids? 2013 Curr. Med. Chem. pmid:23432580
Gomes FI et al. Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis. 2009 Curr. Microbiol. pmid:19365686
Gomes F et al. Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. 2011 Curr. Microbiol. pmid:21800262
Hampton RY Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation. 1998 Curr. Opin. Lipidol. pmid:9559264
Hogan DA and Muhlschlegel FA Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. 2011 Curr. Opin. Microbiol. pmid:22014725
Fuchs BB and Mylonakis E Using non-mammalian hosts to study fungal virulence and host defense. 2006 Curr. Opin. Microbiol. pmid:16814595
Gilpin S and Maibach H Allergic contact dermatitis caused by farnesol: clinical relevance. 2010 Cutan Ocul Toxicol pmid:20858058
Décanis N et al. Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. 2009 Cytokine pmid:19121950
Scheman A et al. European Directive fragrances in natural products. 2014 Mar-Apr Dermatitis pmid:24603515
Thorpe JL et al. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. 2004 Dev. Cell pmid:14960282
Neeman R et al. Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation. 2014 Dig. Dis. Sci. pmid:24942325
Oron T et al. Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid. 2012 Dig. Dis. Sci. pmid:21901261
Zvibel I et al. The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. 2008 Dig. Dis. Sci. pmid:17934818
Gefarnate. 1968 Drug Ther Bull pmid:5722353
Ohguro H et al. Carboxyl methylation and farnesylation of transducin gamma-subunit synergistically enhance its coupling with metarhodopsin II. 1991 EMBO J. pmid:1935895
Shearer AG and Hampton RY Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. 2005 EMBO J. pmid:15635451
Berstein LM et al. New approaches to the understanding of tamoxifen action and resistance. 2003 Endocr. Relat. Cancer pmid:12790788
Leitner JW et al. Hyperinsulinemia potentiates activation of p21Ras by growth factors. 1997 Endocrinology pmid:9112423
Bhavnani BR and Woolever CA Formation of steroids by the pregnant mare. VI. Metabolism of [14C]farnesyl pyrophosphate and [3H]dehydroepiandrosterone injected into the fetus. 1978 Endocrinology pmid:155006
Hogan DA Talking to themselves: autoregulation and quorum sensing in fungi. 2006 Eukaryotic Cell pmid:16607008
de Castro Pimentel Figueiredo B et al. The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death. 2011 Eukaryotic Cell pmid:21131437
Shareck J and Belhumeur P Modulation of morphogenesis in Candida albicans by various small molecules. 2011 Eukaryotic Cell pmid:21642508
Cushion MT et al. Biofilm formation by Pneumocystis spp. 2009 Eukaryotic Cell pmid:18820078
Piispanen AE et al. Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. 2011 Eukaryotic Cell pmid:21908593
Lindsay AK et al. Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. 2012 Eukaryotic Cell pmid:22886999
Langford ML et al. Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death. 2013 Eukaryotic Cell pmid:23873867
Hall RA et al. The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. 2011 Eukaryotic Cell pmid:21666074
Deveau A et al. Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. 2010 Eukaryotic Cell pmid:20118211
Ganguly S et al. Zap1 control of cell-cell signaling in Candida albicans biofilms. 2011 Eukaryotic Cell pmid:21890817
Dumitru R et al. In vivo and in vitro anaerobic mating in Candida albicans. 2007 Eukaryotic Cell pmid:17259544
Kebaara BW et al. Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction. 2008 Eukaryotic Cell pmid:18424510
Westwater C et al. Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. 2005 Eukaryotic Cell pmid:16215173
Martin SW et al. Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth. 2005 Eukaryotic Cell pmid:16002645
Enjalbert B and Whiteway M Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. 2005 Eukaryotic Cell pmid:16002646
Alem MA et al. Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. 2006 Eukaryotic Cell pmid:16980403
Kruppa M et al. The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. 2004 Eukaryotic Cell pmid:15302838
Kraitzer A et al. Novel farnesylthiosalicylate (FTS)-eluting composite structures. 2009 Eur J Pharm Sci pmid:19491026
Töyräs A et al. Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. 2003 Eur J Pharm Sci pmid:12885386
Tisch D et al. Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. 1996 Eur. J. Biochem. pmid:9022678
Mackie H and Overton KH Hydrolysis and isomerization of trans,trans-farnesyl diphosphate by Andrographis tissue-culture enzymes. 1977 Eur. J. Biochem. pmid:198206
Beedle AS et al. The stereochemistry of hydrogen transfer from NADPH catalysed by 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. 1972 Eur. J. Biochem. pmid:4403574
Mau CJ et al. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. 2003 Eur. J. Biochem. pmid:14511375
Parmryd I et al. Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. 1995 Eur. J. Biochem. pmid:8575428
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Zhao Y et al. 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. 2016 Eur. J. Cancer pmid:27710830
Munro E et al. Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. 1994 Eur. J. Clin. Invest. pmid:7890015
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Mor A et al. N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells. 2008 Eur. J. Immunol. pmid:18461565
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Nishio E et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). 1996 Eur. J. Pharmacol. pmid:8773465
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Nishio E et al. Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. 1998 Eur. J. Pharmacol. pmid:9650858
Szilvassy Z et al. Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits. 1998 Eur. J. Pharmacol. pmid:9721042
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Torabi S and Mo H Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation. 2016 Exp. Biol. Med. (Maywood) pmid:26660152
Crick DC et al. Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. 1997 Exp. Cell Res. pmid:9087171
Meigs TE et al. Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. 1995 Exp. Cell Res. pmid:7641798
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Qamar W et al. Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. 2012 Exp. Lung Res. pmid:22168545
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