(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Leukemia, Myeloid, Acute D015470 19 associated lipids
HIV Infections D015658 20 associated lipids
Nerve Sheath Neoplasms D018317 4 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Baker FC et al. Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta. 1983 J. Lipid Res. pmid:6366103
Sofer SS and Rilling HC Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. 1969 J. Lipid Res. pmid:4305712
Slakey LL et al. Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. 1973 J. Lipid Res. pmid:4351784
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Hiyoshi H et al. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. 2003 J. Lipid Res. pmid:12518031
Matsuzawa T et al. EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium. 2014 J. Invest. Dermatol. pmid:24384694
Mor A et al. Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. 2011 J. Invest. Dermatol. pmid:21716322
Hanley K et al. Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. 1999 J. Invest. Dermatol. pmid:10571735
Halaschek-Wiener J et al. Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo. 2003 J. Invest. Dermatol. pmid:12535206
Madhavan K et al. Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase. 1973 J. Insect Physiol. pmid:4631837
Spielman A and Skaff V Inhibition of metamorphosis and of ecdysis in mosquitoes. 1967 J. Insect Physiol. pmid:6043875
Krishnakumaran A and Schneiderman HA Prothoracotrophic activity of compounds that mimic juvenile hormone. 1965 J. Insect Physiol. pmid:5848789
Schneiderman HA et al. Juvenile hormone activity of structurally unrelated compounds. 1965 J. Insect Physiol. pmid:5848792
Lanzrein B Influence of a juvenile hormone analogue on vitellogenin synthesis and oögenesis in larvae of Nauphoeta cinerea. 1974 J. Insect Physiol. pmid:4413859
Roullet JB et al. Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. 1997 J. Hypertens. pmid:9488229
Reif S et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats. 1999 J. Hepatol. pmid:10604579
Reif S et al. Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. 2004 J. Hepatol. pmid:15288472
Lin HP et al. Localization of isoprenylated antigen of hepatitis delta virus by anti-farnesyl antibodies. 1999 J. Gen. Virol. pmid:9934689
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Katsuyama M et al. A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. 2005 J. Dermatol. Sci. pmid:15927813
Katsuyama M et al. A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. 2005 J. Dermatol. Sci. pmid:15927814
Koo H et al. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. 2005 J. Dent. Res. pmid:16246933
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
Roullet JB et al. Farnesyl analogues inhibit vasoconstriction in animal and human arteries. 1996 J. Clin. Invest. pmid:8636420
Zhao M et al. Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18534927
Yang Z et al. Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella. 2004 J. Chem. Ecol. pmid:15139312
Shimomura K et al. 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic). 2010 J. Chem. Ecol. pmid:20607368
Shimomura K et al. Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis. 2008 J. Chem. Ecol. pmid:18351422
Xiao Y et al. A two-component female-produced pheromone of the spider Pholcus beijingensis. 2009 J. Chem. Ecol. pmid:19579045
Shohami E et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. 2003 J. Cereb. Blood Flow Metab. pmid:12796721
Cho SW et al. Positive regulation of osteogenesis by bile acid through FXR. 2013 J. Bone Miner. Res. pmid:23609136
Muramatsu M et al. Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols. 2008 J. Biosci. Bioeng. pmid:18930003
Muramatsu M et al. Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. 2009 J. Biosci. Bioeng. pmid:19577192
Granshaw T et al. Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. 2003 J. Biol. Rhythms pmid:12932081
Chen CK et al. Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. 2010 J. Biol. Inorg. Chem. pmid:19727859
Chen CK et al. The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity. 2008 J. Biol. Inorg. Chem. pmid:18392864
Meigs TE et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. 1996 J. Biol. Chem. pmid:8626470
Ivanov SS et al. Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. 2010 J. Biol. Chem. pmid:20813839
Newman CM et al. Post-translational processing of Schizosaccharomyces pombe YPT proteins. 1992 J. Biol. Chem. pmid:1597466
Bradfute DL et al. Squalene synthase-deficient mutant of Chinese hamster ovary cells. 1992 J. Biol. Chem. pmid:1526971
Gibbs JB et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. 1993 J. Biol. Chem. pmid:8463291
Biermann BJ et al. Novel isoprenylated proteins identified by an expression library screen. 1994 J. Biol. Chem. pmid:7929216
Lerro KA and Prestwich GD Cloning and sequencing of a cDNA for the hemolymph juvenile hormone binding protein of larval Manduca sexta. 1990 J. Biol. Chem. pmid:2246263
Kisselev O et al. Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. 1995 J. Biol. Chem. pmid:7592699
Fujiyama A et al. S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation. 1991 J. Biol. Chem. pmid:1917931
Maltese WA and Erdman RA Characterization of isoprenoid involved in the post-translational modification of mammalian cell proteins. 1989 J. Biol. Chem. pmid:2808372
Keller RK et al. Studies on the regulation of glycoprotein biosynthesis. An investigation of the rate-limiting steps of dolichyl phosphate biosynthesis. 1979 J. Biol. Chem. pmid:489612
Gonzalez-Pacanowska D et al. Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation. 1988 J. Biol. Chem. pmid:3335546
Bostedor RG et al. Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. 1997 J. Biol. Chem. pmid:9083051
Koeppe JK et al. A specific photoaffinity label for hemolymph and ovarian juvenile hormone-binding proteins in Leucophaea maderae. 1984 J. Biol. Chem. pmid:6699014
Christenson JG et al. Enzymatic synthesis of the antigen carrier lipid. 1969 J. Biol. Chem. pmid:4311788
Popják G et al. Biosynthesis and structure of a new intermediate between farnesyl pyrophosphate and squalene. 1969 J. Biol. Chem. pmid:4388617
Heinstein PF et al. Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. 1970 J. Biol. Chem. pmid:4318479
Roullet JB et al. Farnesol inhibits L-type Ca2+ channels in vascular smooth muscle cells. 1997 J. Biol. Chem. pmid:9405427
Edmond J et al. Presqualene alcohol. Further evidence on the structure of a C 30 precursor of squalene. 1971 J. Biol. Chem. pmid:4399596
Cornforth JW et al. Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate. 1966 J. Biol. Chem. pmid:4288360
Allen CM et al. A long chain terpenyl pyrophosphate synthetase from Micrococcus lysodeikticus. 1967 J. Biol. Chem. pmid:4290445
Dorsey JK and Porter JW The inhibition of mevalonic kinase by geranyl and farnesyl pyrophosphates. 1968 J. Biol. Chem. pmid:4300840
Carel K et al. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. 1996 J. Biol. Chem. pmid:8940037
Qureshi AA et al. Lycopersene and prelycopersene pyrophosphate. Intermediates in carotene biosynthesis. 1972 J. Biol. Chem. pmid:4403969
Qureshi AA et al. Squalene synthetase. II. Purification and properties of bakers' yeast enzyme. 1973 J. Biol. Chem. pmid:4348552
Beytia E et al. Squalene synthetase. 3. Mechanism of the reaction. 1973 J. Biol. Chem. pmid:4348553
Derksen A and Cohen P Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro. 1973 J. Biol. Chem. pmid:4355579
Sobotka-Briner C and Chelsky D COOH-terminal methylation of lamin B and inhibition of methylation by farnesylated peptides corresponding to lamin B and other CAAX motif proteins. 1992 J. Biol. Chem. pmid:1601879
McGuire TF et al. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. 1996 J. Biol. Chem. pmid:8910319
Zhang L et al. Isolation and characterization of a prenylcysteine lyase from bovine brain. 1997 J. Biol. Chem. pmid:9287348
Fukada Y et al. Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. 1994 J. Biol. Chem. pmid:8106497
Onono F et al. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. 2013 J. Biol. Chem. pmid:23908355
Gavey KL and Scallen TJ Nonparticipation of 105,000 x g liver supernatant or sterol carrier protein in the enzymatic conversion of farnesyl pyrophosphate to squalene by rat liver microsomes. 1978 J. Biol. Chem. pmid:209043
Miquel K et al. Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. 1998 J. Biol. Chem. pmid:9748300
Anthony ML et al. Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells. 1999 J. Biol. Chem. pmid:10391908
Roullet JB et al. Modulation of neuronal voltage-gated calcium channels by farnesol. 1999 J. Biol. Chem. pmid:10464274
Niv H et al. Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies. 1999 J. Biol. Chem. pmid:9880539
Agnew WS and Popják G Squalene synthetase. Stoichiometry and kinetics of presqualene pyrophosphate and squalene synthesis by yeast microsomes. 1978 J. Biol. Chem. pmid:26684
Slakey LL et al. The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene. 1972 J. Biol. Chem. pmid:4337504
Polito A et al. Artificial substrates in squalene and sterol biosynthesis. 1972 J. Biol. Chem. pmid:4337856
Rosado JA and Sage SO Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. 2001 J. Biol. Chem. pmid:11278479
Wright MM et al. Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. 2001 J. Biol. Chem. pmid:11306571
Daily D et al. Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways. 2001 J. Biol. Chem. pmid:11290748
Epstein WW and Rilling HC Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. 1970 J. Biol. Chem. pmid:4318477
Rilling HC A new intermediate in the biosynthesis of squalene. 1966 J. Biol. Chem. pmid:4287912
Chakrabarti D et al. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum. 2002 J. Biol. Chem. pmid:12194969
Golczak M et al. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. 2008 J. Biol. Chem. pmid:18195010
Joo JH and Jetten AM NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. 2008 J. Biol. Chem. pmid:18424438
Muscio F et al. Prequalene pyrophosphate. A normal intermediate in squalene biosynthesis. 1974 J. Biol. Chem. pmid:4152099
Qureshi AA et al. Biosynthesis of prelycopersene pyrophosphate and lycopersene by squalene synthetase. 1973 J. Biol. Chem. pmid:4144543
Yang W et al. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. 2000 J. Biol. Chem. pmid:10617635
Hanley K et al. Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. 2000 J. Biol. Chem. pmid:10753967
Tschantz WR et al. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. 2001 J. Biol. Chem. pmid:11078725
Hubálek F et al. Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. 2005 J. Biol. Chem. pmid:15710600
Kisselev OG et al. A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. 1994 J. Biol. Chem. pmid:8063769
Lübben M and Morand K Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. 1994 J. Biol. Chem. pmid:8063781
Correll CC et al. Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1994 J. Biol. Chem. pmid:8021239
Cox AD et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 1994 J. Biol. Chem. pmid:8034681
Sever N et al. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. 2003 J. Biol. Chem. pmid:14563840
Fairn GD et al. A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. 2007 J. Biol. Chem. pmid:17164236
Fogelman AM et al. Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia. 1975 J. Biol. Chem. pmid:1116997
de Ropp JS and Troy FA 2H NMR investigation of the organization and dynamics of polyisoprenols in membranes. 1985 J. Biol. Chem. pmid:4066690
Touhara K and Prestwich GD Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs. 1993 J. Biol. Chem. pmid:8396141
Marom M et al. Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. 1995 J. Biol. Chem. pmid:7673206

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