(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Nerve Sheath Neoplasms D018317 4 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Neurilemmoma D009442 10 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Nephritis D009393 19 associated lipids
HIV Infections D015658 20 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

Download all related citations
Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Tsuji F et al. The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. 2011 Bioorg. Med. Chem. Lett. pmid:21636272
Bhagatji P et al. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. 2010 Biophys. J. pmid:21081081
Beedle AM and Zamponi GW Block of voltage-dependent calcium channels by aliphatic monoamines. 2000 Biophys. J. pmid:10866952
Nunes PM et al. Study of trans-trans farnesol effect on hyphae formation by Yarrowia lipolytica. 2013 Bioprocess Biosyst Eng pmid:23715764
Rahman NK et al. Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. 2011 Bioprocess Biosyst Eng pmid:21327986
Ohto C et al. Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. 2009 Biosci. Biotechnol. Biochem. pmid:19129660
Nagai H et al. Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. 2011 Biosci. Biotechnol. Biochem. pmid:21307572
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Song L Recovery of E,E-farnesol from cultures of yeast erg9 mutants: extraction with polymeric beads and purification by normal-phase chromatography. 2009 Jul-Aug Biotechnol. Prog. pmid:19569196
Nasr N et al. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. 2012 Blood pmid:22677126
Rocha GR et al. Effect of tt-farnesol and myricetin on in vitro biofilm formed by Streptococcus mutans and Candida albicans. 2018 BMC Complement Altern Med pmid:29444673
Jeon JG et al. Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. 2009 BMC Microbiol. pmid:19863808
Cerca N et al. Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin. 2012 BMC Res Notes pmid:22591918
Langman MJ et al. Treatment of chronic gastric ulcer with carbenoxolone and gefarnate: a comparative trial. 1973 Br Med J pmid:4577839
Alves FR et al. Antibiofilm and antibacterial activities of farnesol and xylitol as potential endodontic irrigants. 2013 Braz Dent J pmid:23969910
Alves FR et al. Biofilm biomass disruption by natural substances with potential for endodontic use. 2013 Jan-Feb Braz Oral Res pmid:23306623
Journe F et al. Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. 2008 Breast Cancer Res. Treat. pmid:17333335
Still K et al. Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. 2003 Calcif. Tissue Int. pmid:12457261
Braun PC The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. 2005 Can. J. Microbiol. pmid:16234870
Tsimberidou AM et al. Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. 2010 Cancer Chemother. Pharmacol. pmid:19484470
Haklai R et al. Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. 2008 Cancer Chemother. Pharmacol. pmid:17909812
Au-Yeung KK et al. Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. 2008 Cancer Invest. pmid:18608213
Joo JH and Jetten AM Molecular mechanisms involved in farnesol-induced apoptosis. 2010 Cancer Lett. pmid:19520495
Mo H et al. Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas. 2000 Cancer Lett. pmid:10936674
Yazlovitskaya EM and Melnykovych G Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. 1995 Cancer Lett. pmid:7874691
Adany I et al. Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. 1994 Cancer Lett. pmid:8019976
McAnally JA et al. Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. 2003 Cancer Lett. pmid:14643448
Shipman CM et al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. 1998 Cancer Res. pmid:9850051
Blum R et al. Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). 2007 Cancer Res. pmid:17409441
Zhang L and Hill RP Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. 2007 Cancer Res. pmid:17699784
Joo JH et al. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. 2007 Cancer Res. pmid:17699800
Blum R et al. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. 2005 Cancer Res. pmid:15705901
Eskens FA et al. Farnesyl transferase inhibitors: current developments and future perspectives. 2000 Cancer Treat. Rev. pmid:11006134
Ong TP et al. Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. 2006 Carcinogenesis pmid:16332721
Szűcs G et al. Cardioprotection by farnesol: role of the mevalonate pathway. 2013 Cardiovasc Drugs Ther pmid:23673412
Pando R et al. The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. 2010 Mar-Apr Cardiovasc. Pathol. pmid:19144546
Rodríguez C et al. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. 2009 Cardiovasc. Res. pmid:19406911
Yoo S et al. Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. 2011 Caries Res. pmid:21720161
Søgaard M et al. A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. 1994 Cell pmid:7923363
Aronheim A et al. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. 1994 Cell pmid:7923364
Forman BM et al. Identification of a nuclear receptor that is activated by farnesol metabolites. 1995 Cell pmid:7774010
Zoccarato F et al. The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. 2003 Cell Calcium pmid:12618148
Shapira S et al. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. 2007 Cell Death Differ. pmid:17096025
Amos S et al. Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells. 2006 Cell Death Differ. pmid:16239932
Shalom-Feuerstein R et al. Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. 2004 Cell Death Differ. pmid:14576773
Goldberg L et al. FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. 2012 Cell Death Dis pmid:22419113
Charette N et al. Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms. 2013 Cell Death Dis pmid:23348585
Makovski V et al. Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway. 2014 Cell Death Dis pmid:25476905
Okamoto S et al. Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions. 2014 Cell Death Dis pmid:25393473
Lee J et al. Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. 2010 Cell Res. pmid:20603646

Table of Content