(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Makovski V et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. 2012 Int. J. Cancer pmid:21500191
Lim CS et al. Candida and invasive candidiasis: back to basics. 2012 Eur. J. Clin. Microbiol. Infect. Dis. pmid:21544694
Piérard GE et al. Miconazole, a pharmacological barrier to skin fungal infections. 2012 Expert Opin Pharmacother pmid:22568580
Jaggi AS and Singh N Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. 2012 Food Chem. Toxicol. pmid:22326968
Qamar W et al. Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. 2012 Exp. Lung Res. pmid:22168545
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Mor A et al. Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production. 2012 Inflammation pmid:22688643
Cordeiro Rde A et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. 2012 Vet. Microbiol. pmid:22580194
Costa CB et al. Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition. 2012 Anticancer Res. pmid:22399601
Han TL et al. The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. 2012 FEMS Yeast Res. pmid:22846172
Chang W et al. Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. 2012 PLoS ONE pmid:22848547
Lindsay AK et al. Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. 2012 Eukaryotic Cell pmid:22886999
Fu MS et al. Functional characterization of the small heat shock protein Hsp12p from Candida albicans. 2012 PLoS ONE pmid:22880130
Lichtor PA and Miller SJ Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation. 2012 Nat Chem pmid:23174978
Jamalian A et al. Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. 2012 J Mycol Med pmid:23518164
Green SA et al. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). 2012 J. Exp. Bot. pmid:22162874
Shin KO et al. Terpene alcohols inhibit de novo sphingolipid biosynthesis. 2012 Planta Med. pmid:22274813
Jin Y and Qiu FG A convergent stereocontrolled total synthesis of (-)-terpestacin. 2012 Org. Biomol. Chem. pmid:22710980
Mologni L et al. Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells. 2012 PLoS ONE pmid:23227266
Wartenberg D et al. Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. 2012 J Proteomics pmid:22634043
Yu LH et al. Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. 2012 Antimicrob. Agents Chemother. pmid:22106223
Brilhante RS et al. Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei. 2012 Antimicrob. Agents Chemother. pmid:22290941
Falsetta ML et al. Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo. 2012 Antimicrob. Agents Chemother. pmid:22985885
Deveau A and Hogan DA Linking quorum sensing regulation and biofilm formation by Candida albicans. 2011 Methods Mol. Biol. pmid:21031315
Mann FM et al. Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. 2011 FEBS Lett. pmid:21237161
de Castro Pimentel Figueiredo B et al. The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death. 2011 Eukaryotic Cell pmid:21131437
Gomes F et al. Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. 2011 Am. J. Med. Sci. pmid:21107231
Busch S and Unruh T The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. 2011 Biochim. Biophys. Acta pmid:21036141
Shareck J and Belhumeur P Modulation of morphogenesis in Candida albicans by various small molecules. 2011 Eukaryotic Cell pmid:21642508
Yang L et al. ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. 2011 Biochem. Biophys. Res. Commun. pmid:21621522
Barkan B et al. Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling. 2011 Mol. Cancer Ther. pmid:21632464
Yoo S et al. Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. 2011 Caries Res. pmid:21720161
Fitzpatrick AH et al. Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. 2011 Plant J. pmid:21395888
Nevo Y et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. 2011 PLoS ONE pmid:21445359
Khan R and Sultana S Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. 2011 Chem. Biol. Interact. pmid:21453689
Gonçalves O et al. Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. 2011 Mutat. Res. pmid:21453784
Mor A et al. Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. 2011 Inflammation pmid:20706780
Ling Y et al. Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. 2011 J. Med. Chem. pmid:21504204
Jeon JG et al. Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. 2011 Int J Oral Sci pmid:21485314
Navarro-Moll MC et al. In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I. 2011 Exp. Parasitol. pmid:20932829
Huang J et al. Electrohydrodynamic deposition of nanotitanium doped hydroxyapatite coating for medical and dental applications. 2011 J Mater Sci Mater Med pmid:21243517
Hogan DA and Muhlschlegel FA Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. 2011 Curr. Opin. Microbiol. pmid:22014725
Bai C et al. Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans. 2011 Mol. Microbiol. pmid:21992526
Endo S et al. Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. 2011 Chem. Biol. Interact. pmid:21187079
Zhu J et al. Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. 2011 PLoS ONE pmid:22205973
Piispanen AE et al. Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. 2011 Eukaryotic Cell pmid:21908593
Zhang L et al. Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. 2011 PLoS ONE pmid:22174935
Hall RA et al. The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. 2011 Eukaryotic Cell pmid:21666074
Biran A et al. Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. 2011 Int. J. Cancer pmid:20473860
Fong C et al. Monodisperse nonionic isoprenoid-type hexahydrofarnesyl ethylene oxide surfactants: high throughput lyotropic liquid crystalline phase determination. 2011 Langmuir pmid:21294552
Kraitzer A et al. Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro. 2011 J Pharm Sci pmid:20623695
Charron G et al. Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. 2011 Mol Biosyst pmid:21107478
Epplen R et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. 2011 Acta Oncol pmid:20429730
Bendena WG et al. Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. 2011 Gen. Comp. Endocrinol. pmid:21354154
Nagai H et al. Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. 2011 Biosci. Biotechnol. Biochem. pmid:21307572
Rahman NK et al. Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. 2011 Bioprocess Biosyst Eng pmid:21327986
Gori K et al. Alcohol-based quorum sensing plays a role in adhesion and sliding motility of the yeast Debaryomyces hansenii. 2011 FEMS Yeast Res. pmid:22093748
Madhani HD Quorum sensing in fungi: Q&A. 2011 PLoS Pathog. pmid:22046125
Gomes F et al. Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. 2011 Curr. Microbiol. pmid:21800262
Pammi M et al. Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. 2011 Pediatr. Res. pmid:21857375
Teodoro JS et al. Hepatic FXR: key regulator of whole-body energy metabolism. 2011 Trends Endocrinol. Metab. pmid:21862343
Goto T et al. Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21862726
Fitzpatrick AH et al. Roles for farnesol and ABA in Arabidopsis flower development. 2011 Plant Signal Behav pmid:21758018
Mor A et al. Ras inhibition induces insulin sensitivity and glucose uptake. 2011 PLoS ONE pmid:21738773
Sharma M and Prasad R The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans. 2011 Antimicrob. Agents Chemother. pmid:21768514
Nishimori R et al. Biosynthesis of unnatural bacteriochlorophyll c derivatives esterified with α,ω-diols in the green sulfur photosynthetic bacterium Chlorobaculum tepidum. 2011 Biochemistry pmid:21846125
Riely GJ et al. A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations. 2011 J Thorac Oncol pmid:21847063
Ganguly S et al. Zap1 control of cell-cell signaling in Candida albicans biofilms. 2011 Eukaryotic Cell pmid:21890817
Dinamarco TM et al. Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans. 2011 Biochem. Soc. Trans. pmid:21936849
Mor A et al. Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. 2011 J. Invest. Dermatol. pmid:21716322
Tsuji F et al. The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. 2011 Bioorg. Med. Chem. Lett. pmid:21636272
Kaneko M et al. Effect of farnesol on mevalonate pathway of Staphylococcus aureus. 2011 J. Antibiot. pmid:21772307
Pando R et al. The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. 2010 Mar-Apr Cardiovasc. Pathol. pmid:19144546
Ivanov SS et al. Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. 2010 J. Biol. Chem. pmid:20813839
Levy R et al. Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas. 2010 Mol. Cancer Ther. pmid:20682656
Colabardini AC et al. Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. 2010 Mol. Microbiol. pmid:21091509
Charette N et al. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. 2010 Mol. Cancer pmid:20860815
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Bhagatji P et al. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. 2010 Biophys. J. pmid:21081081
Bhandari J et al. Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. 2010 Plant Physiol. pmid:20807998
Jin J et al. Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. 2010 Molecules pmid:21042264
Chen CK et al. Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. 2010 J. Biol. Inorg. Chem. pmid:19727859
Tsimberidou AM et al. Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. 2010 Cancer Chemother. Pharmacol. pmid:19484470
Joo JH and Jetten AM Molecular mechanisms involved in farnesol-induced apoptosis. 2010 Cancer Lett. pmid:19520495
Lee SJ and Moon HI Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. 2010 Immunopharmacol Immunotoxicol pmid:20175741
Yaari-Stark S et al. Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc. 2010 Int. J. Cancer pmid:19998334
Banke TG et al. Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. 2010 Am. J. Physiol., Cell Physiol. pmid:20457836
Ling Y et al. Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents. 2010 Bioorg. Med. Chem. pmid:20435479
Sarazin A et al. In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line. 2010 Med. Mycol. pmid:20438293
Gregus P et al. Ultra high performance liquid chromatography tandem mass spectrometry analysis of quorum-sensing molecules of Candida albicans. 2010 J Pharm Biomed Anal pmid:20580513
Ghosh S et al. Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line. 2010 FEMS Immunol. Med. Microbiol. pmid:20618847
Cugini C et al. Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. 2010 Microbiology (Reading, Engl.) pmid:20656785
Weber K et al. The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species. 2010 Yeast pmid:20641010
Bustinza-Linares E et al. Salirasib in the treatment of pancreatic cancer. 2010 Future Oncol pmid:20528225
Deveau A et al. Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. 2010 Eukaryotic Cell pmid:20118211
Moya M et al. Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. 2010 Chem. Biol. Interact. pmid:20079722
Räikkönen J et al. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Biochem. Pharmacol. pmid:19819230
Doan K et al. In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. 2010 Food Chem. Toxicol. pmid:19747520
Endo S et al. Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. 2010 Bioorg. Med. Chem. pmid:20304656
Dichtl K et al. Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. 2010 Mol. Microbiol. pmid:20398212

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