(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Richards JB and Hemming FW Dolichols, ubiquinones, geranylgeraniol and farnesol as the major metabolites of mevalonate in Phytophthora cactorum. 1972 Biochem. J. pmid:4643705
Rosado JA and Sage SO Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton. 2000 Biochem. J. pmid:10727417
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Joo JH et al. Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells. 2015 Biochem. Pharmacol. pmid:26275811
Ferri N et al. Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation. 2005 Biochem. Pharmacol. pmid:16257390
Erlich S et al. Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells. 2006 Biochem. Pharmacol. pmid:16780807
Hartmann MA et al. Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. 2000 Biochem. Soc. Trans. pmid:11171211
Dinamarco TM et al. Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans. 2011 Biochem. Soc. Trans. pmid:21936849
Lowe PN et al. Expression of polyisoprenylated Ras proteins in the insect/baculovirus system. 1992 Biochem. Soc. Trans. pmid:1397645
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Haklai R et al. Dislodgment and accelerated degradation of Ras. 1998 Biochemistry pmid:9477957
Strickland CL et al. Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. 1998 Biochemistry pmid:9843427
Nishimori R et al. Biosynthesis of unnatural bacteriochlorophyll c derivatives esterified with α,ω-diols in the green sulfur photosynthetic bacterium Chlorobaculum tepidum. 2011 Biochemistry pmid:21846125
Clausen VA et al. Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase. 2001 Biochemistry pmid:11300771
Murataliev MB et al. Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7. 2004 Biochemistry pmid:14967018
Koyama T et al. Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. 1996 Biochemistry pmid:8755734
Busch S and Unruh T The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. 2011 Biochim. Biophys. Acta pmid:21036141
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Dialameh GH et al. Enzymatic alkylation of menaquinone-o to menaquinones microsomes from chick liver. 1970 Biochim. Biophys. Acta pmid:4323518
Aharonson Z et al. Stringent structural requirements for anti-Ras activity of S-prenyl analogues. 1998 Biochim. Biophys. Acta pmid:9545527
Ghosh PM et al. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. 1997 Biochim. Biophys. Acta pmid:9398081
Rowat AC and Davis JH Farnesol-DMPC phase behaviour: a (2)H-NMR study. 2004 Biochim. Biophys. Acta pmid:15003880
Shechter I Biosynthesis of trans-farnesyl triphosphate in Gibberella fujikuroi. 1973 Biochim. Biophys. Acta pmid:4795388
Hecht SM Mass spectrometric identification of some prenylaminopurines. 1970 Biochim. Biophys. Acta pmid:5507911
Shechter I Phosphate transfer from trans-farnesyl triphosphate to AMP in Gibberella fujikuroi. 1974 Biochim. Biophys. Acta pmid:4423368
Elad G et al. Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid. 1999 Biochim. Biophys. Acta pmid:10590312
Bertolino A et al. Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes. 1978 Biochim. Biophys. Acta pmid:210830
Rowat AC et al. Effects of farnesol on the physical properties of DMPC membranes. 2005 Biochim. Biophys. Acta pmid:15963943
Haug JS et al. Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. 1994 Biochim. Biophys. Acta pmid:8061045
DeBarber AE et al. Omega-hydroxylation of farnesol by mammalian cytochromes p450. 2004 Biochim. Biophys. Acta pmid:15158752
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154
Bifulco M et al. Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells. 1999 Biochimie pmid:10401660
Samuel O et al. Preparation of (1-3H) polyprenyl pyrophosphates. 1974 Biochimie pmid:4375498
Zhang X et al. PEG-farnesylthiosalicylate conjugate as a nanomicellar carrier for delivery of paclitaxel. 2013 Bioconjug. Chem. pmid:23425093
Zhang X et al. Reduction-sensitive dual functional nanomicelles for improved delivery of paclitaxel. 2014 Bioconjug. Chem. pmid:25121577
Xia J et al. In vitro inhibitory effects of farnesol and interactions between farnesol and antifungals against biofilms of Candida albicans resistant strains. 2017 Biofouling pmid:28317391
Inoue Y et al. Farnesol-Induced Disruption of the Staphylococcus aureus Cytoplasmic Membrane. 2016 Biol. Pharm. Bull. pmid:27150138
Sato T et al. Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. 2004 Biol. Pharm. Bull. pmid:15133261
Bhattacharyya S et al. Sol-gel silica controlled release thin films for the inhibition of methicillin-resistant Staphylococcus aureus. 2014 Biomaterials pmid:24099711
Xie J et al. Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro. 2006 Biomaterials pmid:16490248
Abdel-Rhman SH et al. Effect of Tyrosol and Farnesol on Virulence and Antibiotic Resistance of Clinical Isolates of Pseudomonas aeruginosa. 2015 Biomed Res Int pmid:26844228
Ling Y et al. Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents. 2010 Bioorg. Med. Chem. pmid:20435479
Ling Y et al. Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents. 2014 Bioorg. Med. Chem. pmid:24300920
Shchepin R et al. Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans. 2008 Bioorg. Med. Chem. pmid:18037299
Endo S et al. Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. 2010 Bioorg. Med. Chem. pmid:20304656
Khalil AA et al. Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke. 2006 Bioorg. Med. Chem. pmid:16458520
Tsuji F et al. The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. 2011 Bioorg. Med. Chem. Lett. pmid:21636272
Bhagatji P et al. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. 2010 Biophys. J. pmid:21081081
Beedle AM and Zamponi GW Block of voltage-dependent calcium channels by aliphatic monoamines. 2000 Biophys. J. pmid:10866952
Nunes PM et al. Study of trans-trans farnesol effect on hyphae formation by Yarrowia lipolytica. 2013 Bioprocess Biosyst Eng pmid:23715764
Rahman NK et al. Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. 2011 Bioprocess Biosyst Eng pmid:21327986
Ohto C et al. Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. 2009 Biosci. Biotechnol. Biochem. pmid:19129660
Nagai H et al. Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. 2011 Biosci. Biotechnol. Biochem. pmid:21307572
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Song L Recovery of E,E-farnesol from cultures of yeast erg9 mutants: extraction with polymeric beads and purification by normal-phase chromatography. 2009 Jul-Aug Biotechnol. Prog. pmid:19569196
Nasr N et al. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. 2012 Blood pmid:22677126
Rocha GR et al. Effect of tt-farnesol and myricetin on in vitro biofilm formed by Streptococcus mutans and Candida albicans. 2018 BMC Complement Altern Med pmid:29444673
Jeon JG et al. Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. 2009 BMC Microbiol. pmid:19863808
Cerca N et al. Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin. 2012 BMC Res Notes pmid:22591918
Langman MJ et al. Treatment of chronic gastric ulcer with carbenoxolone and gefarnate: a comparative trial. 1973 Br Med J pmid:4577839
Alves FR et al. Antibiofilm and antibacterial activities of farnesol and xylitol as potential endodontic irrigants. 2013 Braz Dent J pmid:23969910
Alves FR et al. Biofilm biomass disruption by natural substances with potential for endodontic use. 2013 Jan-Feb Braz Oral Res pmid:23306623
Journe F et al. Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. 2008 Breast Cancer Res. Treat. pmid:17333335
Still K et al. Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. 2003 Calcif. Tissue Int. pmid:12457261
Braun PC The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. 2005 Can. J. Microbiol. pmid:16234870
Tsimberidou AM et al. Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. 2010 Cancer Chemother. Pharmacol. pmid:19484470
Haklai R et al. Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. 2008 Cancer Chemother. Pharmacol. pmid:17909812
Au-Yeung KK et al. Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. 2008 Cancer Invest. pmid:18608213
Joo JH and Jetten AM Molecular mechanisms involved in farnesol-induced apoptosis. 2010 Cancer Lett. pmid:19520495
Mo H et al. Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas. 2000 Cancer Lett. pmid:10936674
Yazlovitskaya EM and Melnykovych G Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. 1995 Cancer Lett. pmid:7874691
Adany I et al. Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. 1994 Cancer Lett. pmid:8019976
McAnally JA et al. Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. 2003 Cancer Lett. pmid:14643448
Shipman CM et al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. 1998 Cancer Res. pmid:9850051
Blum R et al. Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). 2007 Cancer Res. pmid:17409441
Zhang L and Hill RP Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. 2007 Cancer Res. pmid:17699784
Joo JH et al. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. 2007 Cancer Res. pmid:17699800
Blum R et al. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. 2005 Cancer Res. pmid:15705901
Eskens FA et al. Farnesyl transferase inhibitors: current developments and future perspectives. 2000 Cancer Treat. Rev. pmid:11006134
Ong TP et al. Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. 2006 Carcinogenesis pmid:16332721
Szűcs G et al. Cardioprotection by farnesol: role of the mevalonate pathway. 2013 Cardiovasc Drugs Ther pmid:23673412
Pando R et al. The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. 2010 Mar-Apr Cardiovasc. Pathol. pmid:19144546
Rodríguez C et al. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. 2009 Cardiovasc. Res. pmid:19406911
Yoo S et al. Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. 2011 Caries Res. pmid:21720161
Søgaard M et al. A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. 1994 Cell pmid:7923363
Aronheim A et al. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. 1994 Cell pmid:7923364
Forman BM et al. Identification of a nuclear receptor that is activated by farnesol metabolites. 1995 Cell pmid:7774010
Zoccarato F et al. The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. 2003 Cell Calcium pmid:12618148
Shapira S et al. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. 2007 Cell Death Differ. pmid:17096025
Amos S et al. Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells. 2006 Cell Death Differ. pmid:16239932
Shalom-Feuerstein R et al. Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. 2004 Cell Death Differ. pmid:14576773
Goldberg L et al. FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. 2012 Cell Death Dis pmid:22419113
Charette N et al. Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms. 2013 Cell Death Dis pmid:23348585
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Okamoto S et al. Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions. 2014 Cell Death Dis pmid:25393473
Lee J et al. Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. 2010 Cell Res. pmid:20603646

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