(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Hamada M et al. Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells. 2002 FEBS Lett. pmid:11943160
Takahashi N et al. Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. 2002 FEBS Lett. pmid:11943173
Ghosh S et al. Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line. 2010 FEMS Immunol. Med. Microbiol. pmid:20618847
Inoue Y et al. The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. 2004 FEMS Microbiol. Lett. pmid:15321680
Kuroda M et al. Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus. 2007 FEMS Microbiol. Lett. pmid:17559400
Semighini CP et al. Inhibition of Fusarium graminearum growth and development by farnesol. 2008 FEMS Microbiol. Lett. pmid:18201191
Han TL et al. The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. 2012 FEMS Yeast Res. pmid:22846172
Gori K et al. Alcohol-based quorum sensing plays a role in adhesion and sliding motility of the yeast Debaryomyces hansenii. 2011 FEMS Yeast Res. pmid:22093748
Jabra-Rizk MA et al. Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance. 2006 FEMS Yeast Res. pmid:17042756
Ha J et al. Determination of E,E-farnesol in Makgeolli (rice wine) using dynamic headspace sampling and stir bar sorptive extraction coupled with gas chromatography-mass spectrometry. 2014 Food Chem pmid:24001815
Lapczynski A et al. Fragrance material review on farnesol. 2008 Food Chem. Toxicol. pmid:18640198
Jaggi AS and Singh N Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. 2012 Food Chem. Toxicol. pmid:22326968
Doan K et al. In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. 2010 Food Chem. Toxicol. pmid:19747520
de Oliveira Júnior WM et al. Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice. 2013 Fundam Clin Pharmacol pmid:22340189
Dinamarco TM et al. The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. 2010 Fungal Genet. Biol. pmid:20654725
Langford ML et al. Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans. 2009 Future Microbiol pmid:19995193
Bustinza-Linares E et al. Salirasib in the treatment of pancreatic cancer. 2010 Future Oncol pmid:20528225
Tamone SL et al. Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. 1997 Gen. Comp. Endocrinol. pmid:9038249
Bendena WG et al. Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. 2011 Gen. Comp. Endocrinol. pmid:21354154
McCaffery AR and Highnam KC Effects of corpus aliatum hormone and its mimics on the activity of the cerebral neurosecretory system of Locusta migratoria migratorioides R. & F. 1975 Gen. Comp. Endocrinol. pmid:1132652
De Loof A The essence of female-male physiological dimorphism: differential Ca2+-homeostasis enabled by the interplay between farnesol-like endogenous sesquiterpenoids and sex-steroids? The Calcigender paradigm. 2015 Gen. Comp. Endocrinol. pmid:25540913
Prestwich GD et al. Binding proteins for methyl farnesoate in lobster tissues: detection by photoaffinity labeling. 1990 Gen. Comp. Endocrinol. pmid:2074002
Bryant PJ and Sang JH Physiological genetics of melanotic tumors in Drosophila melanogaster. VI. The tumorigenic effects of juvenile hormone-like substances. 1969 Genetics pmid:5371022
Lombardi L et al. Circadian rhythms in Neurospora crassa: clock mutant effects in the absence of a frq-based oscillator. 2007 Genetics pmid:17237512
Semighini CP et al. Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA. 2006 Genetics pmid:16510786
Jensen EC et al. Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens. 2006 Genome pmid:16699554
Mallat A et al. Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. 1994 Hepatology pmid:7982659
Jahangir T et al. Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats. 2006 Hum Exp Toxicol pmid:16758765
Katzav A et al. Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome. 2003 Immunobiology pmid:12638903
Aronovich R et al. Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms. 2005 Immunobiology pmid:16325498
Lee SJ and Moon HI Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. 2010 Immunopharmacol Immunotoxicol pmid:20175741
Hirohata S et al. Inhibition of human B cell activation by a novel nonsteroidal anti-inflammatory drug, indometacin famesil. 1999 Immunopharmacology pmid:10598881
Goodman CL et al. Partial morphological and functional characterization of the corpus allatum-corpus cardiacum complex from the two-spotted stinkbug, Perillus bioculatus (Hemiptera: Pentatomidae). 2005 Mar-Apr In Vitro Cell. Dev. Biol. Anim. pmid:16029075
Geraldo IM et al. Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents. 2008 Infect Control Hosp Epidemiol pmid:18616390
Shintre MS et al. Evaluation of an alcohol-based surgical hand disinfectant containing a synergistic combination of farnesol and benzethonium chloride for immediate and persistent activity against resident hand flora of volunteers and with a novel in vitro pig skin model. 2007 Infect Control Hosp Epidemiol pmid:17265401
Rennemeier C et al. Microbial quorum-sensing molecules induce acrosome loss and cell death in human spermatozoa. 2009 Infect. Immun. pmid:19687207
Sabra A et al. Host-pathogen interaction and signaling molecule secretion are modified in the dpp3 knockout mutant of Candida lusitaniae. 2014 Infect. Immun. pmid:24191303
Navarathna DH et al. Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. 2007 Infect. Immun. pmid:17283095
Navarathna DH et al. Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. 2007 Infect. Immun. pmid:17517874
Hargarten JC et al. Candida albicans Quorum Sensing Molecules Stimulate Mouse Macrophage Migration. 2015 Infect. Immun. pmid:26195556
Mor A et al. Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. 2011 Inflammation pmid:20706780
Mor A et al. Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production. 2012 Inflammation pmid:22688643
Rivera-Perez C et al. Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes. 2013 Insect Biochem. Mol. Biol. pmid:23639754
Sperry AE and Sen SE Farnesol oxidation in insects: evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase. 2001 Insect Biochem. Mol. Biol. pmid:11164339
Sen SE et al. Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. 2003 Insect Biochem. Mol. Biol. pmid:12770578
Wozniak M et al. Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle. 2004 Insect Biochem. Mol. Biol. pmid:15522611
Shintre MS et al. Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride. 2006 Int J Hyg Environ Health pmid:16750419
Jeon JG et al. Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. 2011 Int J Oral Sci pmid:21485314
Nokhodchi A et al. The effect of terpene concentrations on the skin penetration of diclofenac sodium. 2007 Int J Pharm pmid:17174049
Makovski V et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. 2012 Int. J. Cancer pmid:21500191
Yaari-Stark S et al. Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc. 2010 Int. J. Cancer pmid:19998334
Biran A et al. Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. 2011 Int. J. Cancer pmid:20473860
Egozi Y et al. Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist. 1999 Int. J. Cancer pmid:10074926
Smalley KS and Eisen TG Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. 2002 Int. J. Cancer pmid:11920610
Smalley KS and Eisen TG Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. 2003 Int. J. Cancer pmid:12673674
Yue W et al. Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells. 2005 Int. J. Cancer pmid:15957161
Blum R et al. E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition. 2006 Int. J. Cancer pmid:16496386
Beiner ME et al. Ras antagonist inhibits growth and chemosensitizes human epithelial ovarian cancer cells. 2006 Jan-Feb Int. J. Gynecol. Cancer pmid:16515591
Davey KG and Sommerville RI Molting in a parasitic nematode, Phocanema decipiens. VII. The mode of action of the ecdysial hormone. 1974 Int. J. Parasitol. pmid:4853251
Tofts J and Meerovitch E The effect of farnesyl methyl ether, a mimic of insect juvenile hormone, on Hymenolepis Diminuta in vitro. 1974 Int. J. Parasitol. pmid:4822487
Davey KG Molting in a parasitic nematode, Phocanema decipiens. VI. The mode of action of insect juvenile hormone and farnesyl methyl ether. 1971 Int. J. Parasitol. pmid:5161204
Laheru D et al. Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. 2012 Invest New Drugs pmid:22547163
Eglin D et al. Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. 2010 J Biomed Mater Res A pmid:19191318
Kraitzer A et al. Mechanisms of antiproliferative drug release from bioresorbable porous structures. 2013 J Biomed Mater Res A pmid:23065767
Unnanuntana A et al. The effects of farnesol on Staphylococcus aureus biofilms and osteoblasts. An in vitro study. 2009 J Bone Joint Surg Am pmid:19884443
Kubesová A et al. Separation of attogram terpenes by the capillary zone electrophoresis with fluorometric detection. 2010 J Chromatogr A pmid:20933239
Cagliero C et al. Analysis of essential oils and fragrances with a new generation of highly inert gas chromatographic columns coated with ionic liquids. 2017 J Chromatogr A pmid:28343686
Lee H et al. Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor coypus) by gas chromatography-mass spectrometry and gas chromatography-infrared spectrometry. 2007 J Chromatogr A pmid:17709112
Kang L et al. SMGA gels for the skin permeation of haloperidol. 2005 J Control Release pmid:15975680
Novák VJ Morphogenetic analysis of the effects of juvenile hormone analogues and other morphogenetically active substances on embryos of Schistocerca gregaria (Forskål). 1969 J Embryol Exp Morphol pmid:5765790
Woodard B et al. 3D-QSAR of fungal quorum-sensing inhibiting analogs of farnesol. 2007 Mar-Apr J Environ Sci Health B pmid:17454380
Jahangir T and Sultana S Benzo(a)pyrene-induced genotoxicity: attenuation by farnesol in a mouse model. 2008 J Enzyme Inhib Med Chem pmid:18618320
Rüegg T et al. 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium. 2006 J Ethnopharmacol pmid:16266794
Huang J et al. Electrohydrodynamic deposition of nanotitanium doped hydroxyapatite coating for medical and dental applications. 2011 J Mater Sci Mater Med pmid:21243517
Jamalian A et al. Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. 2012 J Mycol Med pmid:23518164
Gregus P et al. Ultra high performance liquid chromatography tandem mass spectrometry analysis of quorum-sensing molecules of Candida albicans. 2010 J Pharm Biomed Anal pmid:20580513
Teshima K and Kondo T Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride. 2008 J Pharm Biomed Anal pmid:18313250
Wang Z et al. Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. 2003 Jan-Apr J Pharm Pharm Sci pmid:12753732
Kraitzer A et al. Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro. 2011 J Pharm Sci pmid:20623695
Abu-Mustafa EA et al. Natural coumarins. XII. Umbelliprenin, a constituent of ammi majus L. fruits. 1971 J Pharm Sci pmid:5125784
Wartenberg D et al. Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. 2012 J Proteomics pmid:22634043
Riely GJ et al. A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations. 2011 J Thorac Oncol pmid:21847063
Okazaki S et al. [A 13-week subcutaneous toxicity study of prednisolone farnesylate (PNF) in rats]. 1992 J Toxicol Sci pmid:1293320
Nagashima Y et al. [A 13-week percutaneous toxicity study of prednisolone farnesylate (PNF) gel in beagle dogs with a recovery period of 5 weeks]. 1992 J Toxicol Sci pmid:1293321
Nagashima Y et al. [A 52-week percutaneous toxicity study of prednisolone farnesylate (PNF) gel in beagle dogs with a recovery period of 8 weeks]. 1992 J Toxicol Sci pmid:1293322
Taniguchi H et al. [Reproductive and developmental toxicity study of prednisolone farnesylate (PNF)--study by subcutaneous administration of PNF prior to and in the early stages of pregnancy in rats]. 1992 J Toxicol Sci pmid:1293323
Taniguchi H et al. [Reproductive and developmental toxicity study of prednisolone farnesylate (PNF)--study by subcutaneous administration of PNF during the period of fetal organogenesis in rats]. 1992 J Toxicol Sci pmid:1293324
Aso S et al. [Reproductive and developmental toxicity study of prednisolone farnesylate (PNF)--teratogenicity study in rabbits by subcutaneous administration]. 1992 J Toxicol Sci pmid:1293325
Taniguchi H et al. [Reproductive and developmental toxicity study of prednisolone farnesylate (PNF)--study of subcutaneous administration of PNF during the perinatal and lactation periods in rats]. 1992 J Toxicol Sci pmid:1293326
Otsuka M et al. [Mutagenicity studies of prednisolone farnesylate (PNF)]. 1992 J Toxicol Sci pmid:1293327
Uchiyama H et al. [Effects of prednisolone farnesylate (PNF) gel on skin and ocular mucosa]. 1992 J Toxicol Sci pmid:1293328
Okazaki S et al. [A 13-week dermal toxicity study of prednisolone farnesylate (PNF) gel in rats with a recovery period of 5 weeks]. 1992 J Toxicol Sci pmid:1293330
Okazaki S et al. [A 52-week dermal toxicity study of prednisolone farnesylate (PNF) gel in rats with a recovery period of 8 weeks]. 1992 J Toxicol Sci pmid:1293331
Radetich B and Corey EJ A general stereocontrolled, convergent synthesis of oligoprenols that parallels the biosynthetic pathway. 2002 J. Am. Chem. Soc. pmid:11890779
Clarke HC et al. Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. 2003 J. Am. Soc. Nephrol. pmid:12660318
Williams JM and Savage CO Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. 2005 J. Am. Soc. Nephrol. pmid:15548565
Nozawa Y et al. Stachybotrin C and parvisporin, novel neuritogenic compounds. II. Structure determination. 1997 J. Antibiot. pmid:9315075
Cerca N et al. Farnesol induces cell detachment from established S. epidermidis biofilms. 2013 J. Antibiot. pmid:23549353
Kaneko M et al. Effect of farnesol on mevalonate pathway of Staphylococcus aureus. 2011 J. Antibiot. pmid:21772307
Katragkou A et al. In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms. 2015 J. Antimicrob. Chemother. pmid:25288679

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