(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Barkan B et al. Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling. 2011 Mol. Cancer Ther. pmid:21632464
Yang L et al. ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. 2011 Biochem. Biophys. Res. Commun. pmid:21621522
Lim CS et al. Candida and invasive candidiasis: back to basics. 2012 Eur. J. Clin. Microbiol. Infect. Dis. pmid:21544694
Ling Y et al. Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. 2011 J. Med. Chem. pmid:21504204
Makovski V et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. 2012 Int. J. Cancer pmid:21500191
Jeon JG et al. Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. 2011 Int J Oral Sci pmid:21485314
Gonçalves O et al. Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. 2011 Mutat. Res. pmid:21453784
Khan R and Sultana S Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. 2011 Chem. Biol. Interact. pmid:21453689
Nevo Y et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. 2011 PLoS ONE pmid:21445359
Fitzpatrick AH et al. Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. 2011 Plant J. pmid:21395888
Bendena WG et al. Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. 2011 Gen. Comp. Endocrinol. pmid:21354154
Aclé D et al. Activity of the corpora allata of adult female Leucophaea maderae: effects of mating and feeding. 1990 Arch. Insect Biochem. Physiol. pmid:2134173
Rahman NK et al. Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. 2011 Bioprocess Biosyst Eng pmid:21327986
Nagai H et al. Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. 2011 Biosci. Biotechnol. Biochem. pmid:21307572
Fong C et al. Monodisperse nonionic isoprenoid-type hexahydrofarnesyl ethylene oxide surfactants: high throughput lyotropic liquid crystalline phase determination. 2011 Langmuir pmid:21294552
Huang J et al. Electrohydrodynamic deposition of nanotitanium doped hydroxyapatite coating for medical and dental applications. 2011 J Mater Sci Mater Med pmid:21243517
Mann FM et al. Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. 2011 FEBS Lett. pmid:21237161
Endo S et al. Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. 2011 Chem. Biol. Interact. pmid:21187079
de Castro Pimentel Figueiredo B et al. The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death. 2011 Eukaryotic Cell pmid:21131437
Charron G et al. Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. 2011 Mol Biosyst pmid:21107478
Gomes F et al. Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. 2011 Am. J. Med. Sci. pmid:21107231
Colabardini AC et al. Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. 2010 Mol. Microbiol. pmid:21091509
Bertolino A et al. Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes. 1978 Biochim. Biophys. Acta pmid:210830
Bhagatji P et al. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. 2010 Biophys. J. pmid:21081081
Jin J et al. Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. 2010 Molecules pmid:21042264
Busch S and Unruh T The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. 2011 Biochim. Biophys. Acta pmid:21036141
Deveau A and Hogan DA Linking quorum sensing regulation and biofilm formation by Candida albicans. 2011 Methods Mol. Biol. pmid:21031315
Kubesová A et al. Separation of attogram terpenes by the capillary zone electrophoresis with fluorometric detection. 2010 J Chromatogr A pmid:20933239
Navarro-Moll MC et al. In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I. 2011 Exp. Parasitol. pmid:20932829
Gavey KL and Scallen TJ Nonparticipation of 105,000 x g liver supernatant or sterol carrier protein in the enzymatic conversion of farnesyl pyrophosphate to squalene by rat liver microsomes. 1978 J. Biol. Chem. pmid:209043
Aizman E et al. The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice. 2010 J. Neuroimmunol. pmid:20869125
Charette N et al. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. 2010 Mol. Cancer pmid:20860815
Gilpin S and Maibach H Allergic contact dermatitis caused by farnesol: clinical relevance. 2010 Cutan Ocul Toxicol pmid:20858058
Ivanov SS et al. Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. 2010 J. Biol. Chem. pmid:20813839
Bhandari J et al. Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. 2010 Plant Physiol. pmid:20807998
Prestwich GD et al. Binding proteins for methyl farnesoate in lobster tissues: detection by photoaffinity labeling. 1990 Gen. Comp. Endocrinol. pmid:2074002
Mor A et al. Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. 2011 Inflammation pmid:20706780
Levy R et al. Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas. 2010 Mol. Cancer Ther. pmid:20682656
Cugini C et al. Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. 2010 Microbiology (Reading, Engl.) pmid:20656785
Dinamarco TM et al. The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. 2010 Fungal Genet. Biol. pmid:20654725
Weber K et al. The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species. 2010 Yeast pmid:20641010
Kraitzer A et al. Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro. 2011 J Pharm Sci pmid:20623695
Ghosh S et al. Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line. 2010 FEMS Immunol. Med. Microbiol. pmid:20618847
Shimomura K et al. 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic). 2010 J. Chem. Ecol. pmid:20607368
Lee J et al. Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. 2010 Cell Res. pmid:20603646
Gregus P et al. Ultra high performance liquid chromatography tandem mass spectrometry analysis of quorum-sensing molecules of Candida albicans. 2010 J Pharm Biomed Anal pmid:20580513
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Bustinza-Linares E et al. Salirasib in the treatment of pancreatic cancer. 2010 Future Oncol pmid:20528225
Biran A et al. Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. 2011 Int. J. Cancer pmid:20473860
Banke TG et al. Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. 2010 Am. J. Physiol., Cell Physiol. pmid:20457836
Sarazin A et al. In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line. 2010 Med. Mycol. pmid:20438293
Ling Y et al. Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents. 2010 Bioorg. Med. Chem. pmid:20435479
Epplen R et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. 2011 Acta Oncol pmid:20429730
Dichtl K et al. Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. 2010 Mol. Microbiol. pmid:20398212
Endo S et al. Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. 2010 Bioorg. Med. Chem. pmid:20304656
Lee SJ and Moon HI Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. 2010 Immunopharmacol Immunotoxicol pmid:20175741
Deveau A et al. Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. 2010 Eukaryotic Cell pmid:20118211
Moya M et al. Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. 2010 Chem. Biol. Interact. pmid:20079722
Yaari-Stark S et al. Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc. 2010 Int. J. Cancer pmid:19998334
Langford ML et al. Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans. 2009 Future Microbiol pmid:19995193
Mayoral JG et al. NADP+-dependent farnesol dehydrogenase, a corpora allata enzyme involved in juvenile hormone synthesis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19940247
Langford ML et al. Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. 2010 Antimicrob. Agents Chemother. pmid:19933803
Keung WM Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism. 1991 Biochem. Biophys. Res. Commun. pmid:1993065
Unnanuntana A et al. The effects of farnesol on Staphylococcus aureus biofilms and osteoblasts. An in vitro study. 2009 J Bone Joint Surg Am pmid:19884443
Jeon JG et al. Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. 2009 BMC Microbiol. pmid:19863808
Chagas CE et al. Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats. 2009 Sep-Oct Acta Cir Bras pmid:19851690
Hanker AB et al. Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. 2010 Oncogene pmid:19838215
Mackie H and Overton KH Hydrolysis and isomerization of trans,trans-farnesyl diphosphate by Andrographis tissue-culture enzymes. 1977 Eur. J. Biochem. pmid:198206
Räikkönen J et al. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Biochem. Pharmacol. pmid:19819230
Raptis C et al. Acid-catalyzed cyclization of terpenes under homogeneous and heterogeneous conditions as probed through stereoisotopic studies: a concerted process with competing preorganized chair and boat transition states. 2009 Chemistry pmid:19780112
Doan K et al. In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. 2010 Food Chem. Toxicol. pmid:19747520
Chen CK et al. Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. 2010 J. Biol. Inorg. Chem. pmid:19727859
Koo H and Jeon JG Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms. 2009 Adv. Dent. Res. pmid:19717411
Chen F et al. Tooth-binding micelles for dental caries prevention. 2009 Antimicrob. Agents Chemother. pmid:19704121
Rennemeier C et al. Microbial quorum-sensing molecules induce acrosome loss and cell death in human spermatozoa. 2009 Infect. Immun. pmid:19687207
Goldstein JL and Brown MS Regulation of the mevalonate pathway. 1990 Nature pmid:1967820
Xiao Y et al. A two-component female-produced pheromone of the spider Pholcus beijingensis. 2009 J. Chem. Ecol. pmid:19579045
Muramatsu M et al. Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. 2009 J. Biosci. Bioeng. pmid:19577192
Song L Recovery of E,E-farnesol from cultures of yeast erg9 mutants: extraction with polymeric beads and purification by normal-phase chromatography. 2009 Jul-Aug Biotechnol. Prog. pmid:19569196
Mor A et al. Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. 2009 Eur. J. Pharmacol. pmid:19527709
Joo JH and Jetten AM Molecular mechanisms involved in farnesol-induced apoptosis. 2010 Cancer Lett. pmid:19520495
Abe S et al. Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress. 2009 Microbiol. Immunol. pmid:19493200
Kraitzer A et al. Novel farnesylthiosalicylate (FTS)-eluting composite structures. 2009 Eur J Pharm Sci pmid:19491026
Tsimberidou AM et al. Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. 2010 Cancer Chemother. Pharmacol. pmid:19484470
Chaudhary SC et al. Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. 2009 Life Sci. pmid:19470390
Rhome R and Del Poeta M Lipid signaling in pathogenic fungi. 2009 Annu. Rev. Microbiol. pmid:19450140
Schneider-Merck T et al. The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats. 2009 Eur. J. Cancer pmid:19427195
Pando R et al. Ras inhibition attenuates myocardial ischemia-reperfusion injury. 2009 Biochem. Pharmacol. pmid:19426696
Rodríguez C et al. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. 2009 Cardiovasc. Res. pmid:19406911
Derengowski LS et al. Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. 2009 Ann. Clin. Microbiol. Antimicrob. pmid:19402910
Gomes FI et al. Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis. 2009 Curr. Microbiol. pmid:19365686
Shirtliff ME et al. Farnesol-induced apoptosis in Candida albicans. 2009 Antimicrob. Agents Chemother. pmid:19364863
Ohguro H et al. Carboxyl methylation and farnesylation of transducin gamma-subunit synergistically enhance its coupling with metarhodopsin II. 1991 EMBO J. pmid:1935895
Banfi C et al. Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme. 2009 Proteomics pmid:19253276
Eglin D et al. Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. 2010 J Biomed Mater Res A pmid:19191318
Fujiyama A et al. S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation. 1991 J. Biol. Chem. pmid:1917931
Pando R et al. The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. 2010 Mar-Apr Cardiovasc. Pathol. pmid:19144546
Ohto C et al. Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. 2009 Biosci. Biotechnol. Biochem. pmid:19129660
Décanis N et al. Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. 2009 Cytokine pmid:19121950
Togashi N et al. Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus. 2008 Molecules pmid:19078849

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