(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Rowat AC and Davis JH Farnesol-DMPC phase behaviour: a (2)H-NMR study. 2004 Biochim. Biophys. Acta pmid:15003880
Shalom-Feuerstein R et al. Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. 2004 Cell Death Differ. pmid:14576773
Thorpe JL et al. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. 2004 Dev. Cell pmid:14960282
George J et al. Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14670932
Wang Z et al. Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. 2003 Jan-Apr J Pharm Pharm Sci pmid:12753732
Lochnit G and Geyer R Evidence for the presence of the Kennedy and Bremer- Greenberg pathways in Caenorhabditis elegans. 2003 Acta Biochim. Pol. pmid:14740010
Sakata T et al. Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae). 2003 Exp. Appl. Acarol. pmid:14635814
Granshaw T et al. Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. 2003 J. Biol. Rhythms pmid:12932081
Koo H et al. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. 2003 J. Antimicrob. Chemother. pmid:14563892
Tóth M et al. Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. 2003 Pest Manag. Sci. pmid:12701702
Sen SE et al. Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. 2003 Insect Biochem. Mol. Biol. pmid:12770578
Katzav A et al. Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome. 2003 Immunobiology pmid:12638903
Berstein LM et al. New approaches to the understanding of tamoxifen action and resistance. 2003 Endocr. Relat. Cancer pmid:12790788
Shohami E et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. 2003 J. Cereb. Blood Flow Metab. pmid:12796721
Hornby JM et al. Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. 2003 Antimicrob. Agents Chemother. pmid:12821501
Xu L and Simoni RD The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. 2003 Arch. Biochem. Biophys. pmid:12781775
Dietrich A et al. Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. 2003 Biochem. J. pmid:12952523
Shchepin R et al. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. 2003 Chem. Biol. pmid:12954333
Giricz Z et al. Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. 2003 Basic Res. Cardiol. pmid:12955403
Iguchi T et al. Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. 2003 Cell. Signal. pmid:12742232
Clarke HC et al. Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. 2003 J. Am. Soc. Nephrol. pmid:12660318
Jones TH et al. Farnesylamine from the ant Monomorium fieldi Forel. 2003 J. Nat. Prod. pmid:12662086
Smalley KS and Eisen TG Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. 2003 Int. J. Cancer pmid:12673674
Song L Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants. 2003 Anal. Biochem. pmid:12758256
Halaschek-Wiener J et al. Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo. 2003 J. Invest. Dermatol. pmid:12535206
Zoccarato F et al. The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. 2003 Cell Calcium pmid:12618148
Still K et al. Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. 2003 Calcif. Tissue Int. pmid:12457261
Hiyoshi H et al. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. 2003 J. Lipid Res. pmid:12518031
Töyräs A et al. Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. 2003 Eur J Pharm Sci pmid:12885386
Houten SM et al. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. 2003 Cell. Mol. Life Sci. pmid:12861380
Brehm-Stecher BF and Johnson EA Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. 2003 Antimicrob. Agents Chemother. pmid:14506058
Mau CJ et al. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. 2003 Eur. J. Biochem. pmid:14511375
Li X et al. New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. 2003 J. Nat. Prod. pmid:14640527
McAnally JA et al. Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. 2003 Cancer Lett. pmid:14643448
Sever N et al. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. 2003 J. Biol. Chem. pmid:14563840
Grossman R et al. Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. 2003 Neuroimage pmid:14683703
Koo H et al. Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. 2002 Oral Microbiol. Immunol. pmid:12485324
Schnee C et al. The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. 2002 Plant Physiol. pmid:12481088
Hamada M et al. Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells. 2002 FEBS Lett. pmid:11943160
Gana-Weisz M et al. The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance. 2002 Clin. Cancer Res. pmid:11839677
Smalley KS and Eisen TG Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. 2002 Int. J. Cancer pmid:11920610
Teal PE Effects of allatotropin and allatostatin on in vitro production of juvenile hormones by the corpora allata of virgin females of the moths of Heliothis virescens and Manduca sexta. 2002 Peptides pmid:11897385
Meinhardt G et al. Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. 2002 Anticancer Drugs pmid:12187329
Chakrabarti D et al. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum. 2002 J. Biol. Chem. pmid:12194969
Akiyama H et al. Actions of farnesol and xylitol against Staphylococcus aureus. 2002 Chemotherapy pmid:12138327
Takahashi N et al. Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. 2002 FEBS Lett. pmid:11943173
George J et al. Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. 2002 Circulation pmid:12021230
Raner GM et al. Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes. 2002 Biochem. Biophys. Res. Commun. pmid:12054554
Lagace TA et al. Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. 2002 Mol. Cell. Biol. pmid:12052891
Frenkel J et al. Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. 2002 Arthritis Rheum. pmid:12384940
Ludolph B et al. Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B. 2002 Chembiochem pmid:12210992
Ramage G et al. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. 2002 Appl. Environ. Microbiol. pmid:12406738
Kato N et al. Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. 2002 J. Neurol. Sci. pmid:12220695
Ward SM et al. TGFbeta regulates the expression of G alpha(i2) via an effect on the localization of ras. 2002 J. Mol. Cell. Cardiol. pmid:12392895
Goodwin TE et al. African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol. 2002 J. Nat. Prod. pmid:12350155
Winn LM and Wells PG Evidence for Ras-dependent signal transduction in phenytoin teratogenicity. 2002 Toxicol. Appl. Pharmacol. pmid:12460742
Du Y and Wiemer DF Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis. 2002 J. Org. Chem. pmid:12153272
Radetich B and Corey EJ A general stereocontrolled, convergent synthesis of oligoprenols that parallels the biosynthetic pathway. 2002 J. Am. Chem. Soc. pmid:11890779
Cheng QF et al. Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. 2001 Exp. Eye Res. pmid:11446774
Sperry AE and Sen SE Farnesol oxidation in insects: evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase. 2001 Insect Biochem. Mol. Biol. pmid:11164339
Villegas LF et al. (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids. 2001 J. Nat. Prod. pmid:11678668
Mizukami Y et al. Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells. 2001 Biochem. Biophys. Res. Commun. pmid:11594773
Karussis D et al. The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis. 2001 J. Neuroimmunol. pmid:11694313
Kim SY et al. Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism. 2001 Metab. Clin. Exp. pmid:11699057
Sari R et al. Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi. 2001 Eur. J. Pharmacol. pmid:11734192
Rakhit RD et al. Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury. 2001 Biochem. Biophys. Res. Commun. pmid:11527399
Nah J et al. Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation. 2001 Plant Cell Physiol. pmid:11522913
Katzav A et al. Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). 2001 Clin. Exp. Immunol. pmid:11737078
Clausen VA et al. Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase. 2001 Biochemistry pmid:11300771
Rosado JA and Sage SO Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. 2001 J. Biol. Chem. pmid:11278479
Wright MM et al. Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. 2001 J. Biol. Chem. pmid:11306571
Daily D et al. Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways. 2001 J. Biol. Chem. pmid:11290748
Hornby JM et al. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. 2001 Appl. Environ. Microbiol. pmid:11425711
Tschantz WR et al. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. 2001 J. Biol. Chem. pmid:11078725
Hartmann MA et al. Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. 2000 Biochem. Soc. Trans. pmid:11171211
Beedle AM and Zamponi GW Block of voltage-dependent calcium channels by aliphatic monoamines. 2000 Biophys. J. pmid:10866952
Mo H et al. Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas. 2000 Cancer Lett. pmid:10936674
Toró A et al. Transannular Diels-Alder studies on the asymmetric total synthesis of chatancin: the pyranophane approach. 2000 Org. Lett. pmid:10964353
Yang W et al. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. 2000 J. Biol. Chem. pmid:10617635
Hanley K et al. Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. 2000 J. Biol. Chem. pmid:10753967
Bringmann A et al. Farnesol modulates membrane currents in human retinal glial cells. 2000 J. Neurosci. Res. pmid:11054809
Halaschek-Wiener J et al. A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells. 2000 Mol. Med. pmid:11055588
Xie H et al. Synthesis and biological evaluation of the geometric farnesylated analogues of the a-factor mating peptide of Saccharomyces cerevisiae. 2000 J. Org. Chem. pmid:11112575
Eskens FA et al. Farnesyl transferase inhibitors: current developments and future perspectives. 2000 Cancer Treat. Rev. pmid:11006134
Kloog Y and Cox AD RAS inhibitors: potential for cancer therapeutics. 2000 Mol Med Today pmid:11006529
Hemmerlin A and Bach TJ Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in tobacco cv bright yellow-2 cells. 2000 Plant Physiol. pmid:10938345
Mussoni L et al. Fluvastatin inhibits basal and stimulated plasminogen activator inhibitor 1, but induces tissue type plasminogen activator in cultured human endothelial cells. 2000 Thromb. Haemost. pmid:10928471
Rioja A et al. Preferential induction of apoptosis of leukaemic cells by farnesol. 2000 FEBS Lett. pmid:10675556
Hemmer W et al. Axillary dermatitis from farnesol in a deodorant. 2000 Contact Derm. pmid:10727172
Rosado JA and Sage SO Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton. 2000 Biochem. J. pmid:10727417
Flach J et al. The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. 2000 Biochem. Biophys. Res. Commun. pmid:10733934
Parmryd I et al. Protein prenylation in spinach chloroplasts. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10468564
Hanley K et al. Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. 1999 J. Invest. Dermatol. pmid:10571735
Machida K and Tanaka T Farnesol-induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F(0)F(1)-ATPase in yeast. 1999 FEBS Lett. pmid:10580101
Hirohata S et al. Inhibition of human B cell activation by a novel nonsteroidal anti-inflammatory drug, indometacin famesil. 1999 Immunopharmacology pmid:10598881
Shack S et al. Activation of the cholesterol pathway and Ras maturation in response to stress. 1999 Oncogene pmid:10557091
Thai L et al. Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10557276
Jansen B et al. Novel Ras antagonist blocks human melanoma growth. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570191
Elad G et al. Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid. 1999 Biochim. Biophys. Acta pmid:10590312
Reif S et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats. 1999 J. Hepatol. pmid:10604579

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